NOAEL Data REACH Registered Cosmetic Ingredient

2,2'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)phenol)

Also known as: Phenol, 2,2'-(6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)-, Bis-ethylhexyloxyphenol methoxyphenyl triazine, Bemotrizinol

CAS 187393-00-6

2,2'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)phenol) (CAS 187393-00-6) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Bemotrizinol →

SOURCE noael studies public
NOAEL studies
10
SOURCE chemical inventory jurisdictions
Regulatory lists
3
SOURCE eu clp annex vi
GHS signal
Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 9 fields
Name
2,2'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)phenol)
CAS Number
187393-00-6
DTXSID
DTXSID40896984
Molecular Formula
C38H49N3O5
InChI Key
XVAMCHGMPYWHNL-UHFFFAOYSA-N
Monoisotopic Mass
627.367222
Synonyms
Phenol, 2,2'-(6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)-Bis-ethylhexyloxyphenol methoxyphenyl triazineBemotrizinol

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 4 records
UV stabilizerSoftener and conditioner

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 3 records
ListKeywordSource
Europe; Personal careEuropean CommissionCosIng
pharmaceuticalUS International Trade CommissionCPCat
Canada; pharmaceuticalDrugBankDrugBank

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 10 of 10 studies
ValueUnitEndpointRouteSpeciesSource
PWZ1720CBHUNIIFDA UNII substance identifier--openFDA substances
PWZ1720CBHUNIIFDA UNII substance identifier--openFDA substances
PWZ1720CBHUNIIFDA UNII substance identifier--openFDA substances
PWZ1720CBHUNIIFDA UNII substance identifier--openFDA substances
~0.075mg/cm2-dayLELdermalRatToxValDB_ECHA_IUCLID
=649mg/m3LELinhalationRatToxValDB_ECHA_IUCLID
>=1000mg/kg bw/dayNOAELdermalRatToxValDB_ECHA_IUCLID
>=1000mg/kg bw/dayNOAELdermalRatToxValDB_ECHA_IUCLID
>=2000mg/kg bw/dayNOAELoralRatToxValDB_ECHA_IUCLID
>=1250mg/kg bw/dayNOELdermalPigToxValDB_ECHA_IUCLID

Showing 10 of 10 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records
StatusNameEC NumberLink
Registered2,2'-[6-(4-methoxyphenyl)-1,3,5-triazine-2,4-diyl]bis{5-[(2-ethylhexyl)oxy]phenol}425-950-7ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records
Inventory Status
listed_with_terms
Conditions
Specific information requirements: Obligations to provide information apply. These obligations are: 1. If the assessment report about the chemical recommends secondary notification of the chemical in particular circumstances and any of the circumstances occur in relation to the introduction (importation or manufacture) of the chemical by a person, then the person introducing this chemical must tell us in writing within 28 calendar days that the circumstances have occurred. 2. A person who introduces this chemical must tell us in writing within 28 calendar days if they become aware of any of the following circumstances, namely, that since the assessment under the Industrial Chemicals (Notification and Assessment) Act 1989: a. the function or use of the chemical has changed, or is likely to change, significantly; b. the amount of the chemical being introduced has increased, or is likely to increase, significantly; c. in the case of a chemical not manufactured, or proposed to be manufactured, in Australia at the time of the assessment—it has begun to be manufactured in Australia; d. the method of manufacture of the chemical in Australia has changed, or is likely to change, in a way that may result in an increased risk of an adverse effect of the chemical on occupational health and safety, public health or the environment; e. additional information has become available to the person as to an adverse effect of the chemical on occupational health and safety, public health or the environment.

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB
EU Status
permitted
Max
10%
Category
active
View full cosmetic safety profile →

Pharmaceutical Data

Same-CAS pharmaceutical records from drug and bioactivity sources.

SOURCE EMBL-EBI ChEMBL BEMOTRIZINOL
ChEMBL Phase
3
Adverse Events
0
Bioactivity
0
View full pharmaceutical profile →

Frequently Asked Questions

What is the NOAEL for 2,2'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)phenol)?

2,2'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)phenol) has 10 NOAEL studies in the database. The lowest reported value is PWZ1720CBH UNII. Source: openFDA substances.

What regulatory lists include 2,2'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)phenol)?

2,2'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)phenol) appears on 3 regulatory/inventory lists including Europe; Personal care, pharmaceutical, Canada; pharmaceutical. Source: EPA CPDat.

Is 2,2'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)phenol) used in cosmetics?

Yes, 2,2'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)phenol) is also indexed as a cosmetic ingredient under the name Bemotrizinol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 2,2'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)phenol) come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.

Is 2,2'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)phenol) used outside industrial chemicals?

2,2'-(6-(4-Methoxyphenyl)-1,3,5-triazine-2,4-diyl)bis(5-((2-ethylhexyl)oxy)phenol) also appears in cosmetics, pharmaceutical databases.