Is Amiloxate (Isoamyl p-Methoxycinnamate) safe in cosmetics?
Amiloxate (Isoamyl p-Methoxycinnamate) has a safety rating of "GOOD" in our database. EU status: restricted. US status: prohibited.
Amiloxate (Isoamyl p-Methoxycinnamate)
Also known as: 3-10-00-00850, BRN 3132627, EINECS 275-702-5, 3-(4-Methoxyphenyl)-2-propenoic acid, 3-methylbutyl ester, 3-Methylbutyl 3-(4-methoxyphenyl)-2-propenoate (+2 more)
INCI: AMILOXATE
Amiloxate (Isoamyl p-Methoxycinnamate) (CAS 71617-10-2) is a cosmetic uv filter / sunscreen functioning as Antioxidant. NOAEL 200 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted, max 25%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 71617-10-2 →
Auto-generated CPSR Part A draft with source citations
Function
Antioxidant
Safety Rating
GOOD
Chemistry & Identifiers
EC Number
275-702-5
Regulatory Status
EU EU Status
restricted
EU Max Conc.
25%
US US Status
prohibited
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Amiloxate (Isoamyl p-Methoxycinnamate).
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Amiloxate (Isoamyl p-Methoxycinnamate) across SCCS product categories, with measured dermal absorption where available.
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Suspected
Evidence: Moderate
(2016)
Health effects: Yes
Affected pathways: Estrogenic, Thyroid
Regulatory framework: REACH
Source list: II
Cosmetic-Specific Mechanism
Category: UV filter
Receptor targets: ERα, AR, PR
LOEC: 5 µM
EU status: allowed (max 10%)
antagonist (ER, AR, PR)
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex VI — Permitted UV Filters
Max: 10%
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
KR Korea MFDS Annex 2 (Restricted)
Category: UV Filter. Max: 10%.
SA Saudi SFDA (VI - UV Filters)
Max: 0.1.
BRIN Brazil/India Cosmetics
India: Permitted UV Filter · max 0.1
Additional Jurisdictional Restrictions (3)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_uv_filter | 10 | All cosmetics |
| CN | permitted_uv_filter | 10 | All cosmetics |
| BR | permitted_uv_filter | 10 | Sunscreen products |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
UV stabilizer
Regulatory List Membership (2)
EU Regulated in Personal Care
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Amiloxate (Isoamyl p-Methoxycinnamate).
Regulatory Flags
EU Restricted
eu_cosing_listed
Known Synonyms
3-10-00-00850
BRN 3132627
EINECS 275-702-5
3-(4-Methoxyphenyl)-2-propenoic acid, 3-methylbutyl ester
3-Methylbutyl 3-(4-methoxyphenyl)-2-propenoate
Neo Heliopan E1000
UNII-376KTP06K8
Chemical Function
UV stabilizer
Regulatory Lists
Canada; pharmaceutical
Europe; Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
AMILOXATE
ChEMBL ID
CHEMBL1476782
Max Phase
2
Frequently Asked Questions
Is Amiloxate (Isoamyl p-Methoxycinnamate) allowed in the EU?
Amiloxate (Isoamyl p-Methoxycinnamate) EU regulatory status: restricted. Maximum allowed concentration: 25%. This is based on EU Regulation 1223/2009 and its amendments.
What does Amiloxate (Isoamyl p-Methoxycinnamate) do in cosmetics?
Amiloxate (Isoamyl p-Methoxycinnamate) functions as: Antioxidant. It is classified as a UV Filter / Sunscreen in our database. CAS number: 71617-10-2.
Is Amiloxate (Isoamyl p-Methoxycinnamate) used outside cosmetics?
Amiloxate (Isoamyl p-Methoxycinnamate) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Amiloxate (Isoamyl p-Methoxycinnamate) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
GLUCOMANNAN
Excellent
Same category
Humectant, viscosity control agent
Methylene Bis-Benzotriazolyl Tetramethylbutylphenol (Tinosorb M)
Excellent
Same category
UV filter
Saccharide Isomerate
Excellent
Same category
UV Filter
Sulisobenzone (Benzophenone-4)
Excellent
Same category
UV Filter
Amiloxate
Good
Same category
UV Filter
Benzophenone-4
Good
Same category
UV Filter
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
Isoamyl p-Methoxycinnamate
Moderate
Chemical family
UV filter; UV absorber; light stabilizer
AMINO ESTERS-1
Good
Browse nearby
Skin Conditioning
AMINO ESTERS-2
Good
Browse nearby
Skin Conditioning
Is Amiloxate (Isoamyl p-Methoxycinnamate) in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Amiloxate (Isoamyl p-Methoxycinnamate) in your formulation.