Also known as: 2-Hydroxy-4-methoxy-5-sulfobenzophenone, Benzenesulfonic acid, 5-benzoyl-4-hydroxy-2-methoxy-, Benzophenone 4, 2-Hydroxy-4-methoxybenzophenone-5-sulfonic acid, BRN 2889165 (+3 more)
INCI: SULISOBENZONE
Sulisobenzone (Benzophenone-4) (CAS 4065-45-6) is a cosmetic uv filter / sunscreen functioning as UV Filter. NOAEL 620 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; 5 safety opinions reviewed (sccs). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 4065-45-6 →
Sulisobenzone (Benzophenone-4) is classified GHS Danger (H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for Sulisobenzone (Benzophenone-4).
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for Sulisobenzone (Benzophenone-4). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =620 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =620 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =620 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =620 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =1239 mg/kg/day | - | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =1239 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =1239 mg/kg/day | - | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =1239 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
| NOAEL | =1239 mg/kg/day | - | rat | NOAEL study | SCCS_vision_codex |
| NOAEL | =1239 mg/kg bw/day | oral | rat | repeated dose toxicity | SCCS_vision_codex |
Official safety assessments from the Scientific Committee on Consumer Safety (SCCS) and Cosmetic Ingredient Review (CIR).
ed to potential endocrine disrupting properties, the SCCS is of the opinion that benzophenone-4 is safe when used as UV filter up to a maximum concentration of 5% in sunscreen, face and hand cream, all leave-on and rinse-off products (total dermal aggregate), lipstick, sunscreen propellant spray and
ed to potential endocrine disrupting properties, the SCCS is of the opinion that benzophenone-4 is safe when used as UV filter up to a maximum concentration of 5% in sunscreen, face and hand cream, all leave-on and rinse-off products (total dermal aggregate), lipstick, sunscreen propellant spray and
ed to potential endocrine disrupting properties, the SCCS is of the opinion that benzophenone-4 is safe when used as UV filter up to a maximum concentration of 5% in sunscreen, face and hand cream, all leave-on and rinse-off products (total dermal aggregate), lipstick, sunscreen propellant spray and
ed to potential endocrine disrupting properties, the SCCS is of the opinion that benzophenone-4 is safe when used as UV filter up to a maximum concentration of 5% in sunscreen, face and hand cream, all leave-on and rinse-off products (total dermal aggregate), lipstick, sunscreen propellant spray and
ed to potential endocrine disrupting properties, the SCCS is of the opinion that benzophenone-4 is safe when used as UV filter up to a maximum concentration of 5% in sunscreen, face and hand cream, all leave-on and rinse-off products (total dermal aggregate), lipstick, sunscreen propellant spray and
Pre-calculated NOAEL → SED → MoS audit trail for Sulisobenzone (Benzophenone-4) across SCCS product categories, with measured dermal absorption where available.
1 toxicity value from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | =3530 mg/kg | Rat | oral | - | ChemIDplus |
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Source list: II (former)
agonist (ERα, ERβ); antagonist (AR)
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_uv_filter | 5 | All cosmetics |
| ASEAN | permitted_uv_filter | 5% as acid | - |
Cross-database dermal penetration: EPA Dryad physics-based, Roberts Mendeley permeation, and SCCS-aggregated measured values.
| Type | DA % | Method | Skin Model | SCCS Ref |
|---|---|---|---|---|
| measured | 0.8 | method=measured | - | - |
| measured | 5.9 | method=measured | - | - |
| measured | 0.145 | method=measured | - | - |
| measured | 6.18 | method=measured | - | - |
| measured | 0.05 | method=measured | - | - |
1 property record from structured ingredient metadata.
Expert safety assessment and concern-level summary for Sulisobenzone (Benzophenone-4).
Public NOAEL study rows linked to Sulisobenzone (Benzophenone-4) by CAS number or substance name.
Units vary across source rows: mg/kg/day, mg/kg bw/day
| Absorption % | Method | Vehicle |
|---|---|---|
| 0.8 | method=measured | - |
| 5.9 | method=measured | - |
| 0.145 | method=measured | - |
| 6.18 | method=measured | - |
| 0.05 | method=measured | - |
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Sulisobenzone (Benzophenone-4) has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: restricted. 10 toxicological study endpoint(s) are available in our database. This ingredient has been reviewed by sccs.
Sulisobenzone (Benzophenone-4) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
Sulisobenzone (Benzophenone-4) functions as: UV Filter. It is classified as a UV Filter / Sunscreen in our database. CAS number: 4065-45-6.
The NOAEL (No Observed Adverse Effect Level) for Sulisobenzone (Benzophenone-4) is =620 mg/kg bw/day based on a repeated dose toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: SCCS_vision_codex.
Sulisobenzone (Benzophenone-4) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Sulisobenzone (Benzophenone-4) is classified GHS Danger (H315, H317, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Check Sulisobenzone (Benzophenone-4) compliance across multiple jurisdictions:
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