Is Thiamine (Vitamin B1) safe in cosmetics?
Thiamine (Vitamin B1) has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Preservative
Thiamine (Vitamin B1)
Also known as: Vitamin B1, Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-, chloride (1:1), 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium chloride, Aneurine, Apatate Drape (+14 more)
INCI: THIAMINE
Thiamine (Vitamin B1) (CAS 59-43-8) is a cosmetic preservative functioning as Preservative. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in pharmaceutical data.
View industrial chemical safety profile for CAS 59-43-8 →
Auto-generated CPSR Part A draft with source citations
Function
Preservative
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Thiamine (Vitamin B1).
Calculate MoS for your specific formulation with the MoS Calculator.
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Thiamine (Vitamin B1).
Regulatory Flags
fda_food_additive
Known Synonyms
Vitamin B1
Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-, chloride (1:1)
3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium chloride
Aneurine
Apatate Drape
Bethiamin
Oryzanin
Thiacoat
Thiamine monochloride
Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-, chloride
Vitaneurin
Thiamine chloride
Beivon
Thiamin
EC No.: 200-425-3
3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride
Vitamin B1 (thiamine)
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydrox yethyl)-4-methylthiazolium chloride
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methylthiazolium chloride
Chemical Function
Flavouring and nutrient
Regulatory Lists
pharmaceutical
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
inert_ingredient; non_food_use; Pesticides
active_ingredient; animal_products; Europe; pharmaceutical; residue
Europe; supplements
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
THIAMINE
ChEMBL ID
CHEMBL1588
Max Phase
4
Adverse Event Associations
4733
Frequently Asked Questions
Is Thiamine (Vitamin B1) allowed in the EU?
Thiamine (Vitamin B1) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Thiamine (Vitamin B1) do in cosmetics?
Thiamine (Vitamin B1) functions as: Preservative. It is classified as a Preservative in our database. CAS number: 59-43-8.
Is Thiamine (Vitamin B1) used outside cosmetics?
Thiamine (Vitamin B1) also appears in pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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