What is the NOAEL for Thiamine?
Thiamine has 10 NOAEL studies in the database. The lowest reported value is X66NSO3N35 UNII. Source: openFDA substances.
NOAEL Data
Cosmetic Ingredient
Thiamine
Also known as: Vitamin B1, Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-, chloride (1:1), 3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium chloride, Aneurine, Apatate Drape (+15 more)
CAS 59-43-8
Thiamine (CAS 59-43-8) is a chemical substance. Key regulatory status: 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat.
SOURCE
noael studies public
NOAEL studies
10
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
Thiamine
CAS Number
59-43-8
DTXSID
DTXSID2023648
Molecular Formula
C12H17N4OS.ClH
InChI Key
MYVIATVLJGTBFV-UHFFFAOYSA-M
Monoisotopic Mass
301.088985
Synonyms
Vitamin B1Thiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-, chloride (1:1)3-[(4-Amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium chlorideAneurineApatate DrapeBethiaminOryzaninThiacoatThiamine monochlorideThiazolium, 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-5-(2-hydroxyethyl)-4-methyl-, chlorideVitaneurinThiamine chloride
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
Flavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | US International Trade Commission | CPCat |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; animal_products; Europe; pharmaceutical; residue | EU | CPCat |
| Europe; supplements | EU | CPCat |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 10 of 10 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| X66NSO3N35 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| X66NSO3N35 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| X66NSO3N35 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| X66NSO3N35 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 10 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 75 | mg/kg bw/day | NOAEL | oral | mouse | COSMOS_DB |
| 100 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 225 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 1071 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
Showing 10 of 10 studies
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
preservative
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
THIAMINE
ChEMBL Phase
4
Adverse Events
4733
Bioactivity
12
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Thiamine?
Thiamine appears on 6 regulatory/inventory lists including pharmaceutical, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), Canada; pharmaceutical, and 3 more. Source: EPA CPDat.
Is Thiamine used in cosmetics?
Yes, Thiamine is also indexed as a cosmetic ingredient under the name Thiamine (Vitamin B1). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Thiamine come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Thiamine used outside industrial chemicals?
Thiamine also appears in cosmetics, pharmaceutical, food safety, cannabis databases.