Is Tetrahydrofurfuryl Alcohol safe in cosmetics?
Tetrahydrofurfuryl Alcohol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted. 8 toxicological study endpoint(s) are available in our database.
Tetrahydrofurfuryl Alcohol
Also known as: 2-Furanmethanol, tetrahydro-, BRN 0102723, EINECS 202-625-6, FEMA No. 3056, Tetrahydro-2-furfuryl alcohol (+3 more)
INCI: TETRAHYDROFURFURYL ALCOHOL
Tetrahydrofurfuryl Alcohol (CAS 97-99-4) is a cosmetic cosmetic ingredient functioning as Solvent, Fragrance. NOAEL 40 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 97-99-4 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Tetrahydrofurfuryl Alcohol is classified GHS Danger (H319, H360, H227, H315, H336, H361, H373, H360Df) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Solvent, Fragrance
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
oxolan-2-ylmethanol
InChIKey
BSYVTEYKTMYBMK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; TSCA listed; GRAS as flavor (FEMA)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Tetrahydrofurfuryl Alcohol.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
8 study endpoints found for Tetrahydrofurfuryl Alcohol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =39 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =50 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =60 mg/kg bw/day | oral | Mouse | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =78 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =100 mg/kg bw/day | dermal | Rat | acute | ToxValDB_ECHA_IUCLID |
| NOAEL | =150 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =300 mg/kg bw/day | dermal | Rat | acute | ToxValDB_ECHA_IUCLID |
| NOAEL | =760 mg/kg bw/day | oral | Mouse | reproduction developmental | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Pictograms
Excl markWarnCancerHealth haz
Hazard Statements
Combustible liquid Causes serious eye irritation Suspected of damaging fertility or the unborn child
Short-term Exposure Effects
The substance is irritating to the eyes. The substance may cause effects on the central nervous system at high concentrations. This may result in lowering of consciousness.
Long-term Exposure Effects
Animal tests show that this substance possibly causes toxic effects upon human reproduction.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Tetrahydrofurfuryl Alcohol across SCCS product categories, with measured dermal absorption where available.
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
Health HazardHarmful / Irritant
Hazard Class and Category
Repr. 1B; Eye Irrit. 2
Hazard Statements
- H360Df
- H319 Causes serious eye irritation
Inserted via ATP: ATP06
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
EU CosIng Annex Listing
European Commission CosIng database Annex references per Regulation (EC) No 1223/2009.
Annex II — Prohibited
Ref: 1576
(EU) 2019/831
CMR: Reprotoxic Cat. 1B()
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (II - Prohibited)
ASEAN Cosmetic Directive (II)
Ref: 1576
BRIN Brazil/India Cosmetics
India: Prohibited (GNRAS)
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
ICSC Safety Card
1159
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
... Irritating to human ... eyes. | A severe eye irritant. Irritating to skin & mucous membranes.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (2)
JECFA Number
1443
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
TETRAHYDROFURFURYL ALCOHOL | 2004 | No safety concern at current levels of intake when used as a flavouring agent | TRS 928-JECFA 63/106 | FAS 54-JECFA 63/487
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Solvent
Regulatory List Membership (5)
EU Banned in Cosmetics
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Tetrahydrofurfuryl Alcohol.
Regulatory Flags
fragrance-component
eu_banned_cosmetics
ifra_fragrance
fda_food_additive
eu_cosing_listed
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Tetrahydrofurfuryl Alcohol by CAS number or substance name.
Studies
8
Lowest NOAEL
39 mg/kg bw/day
Highest NOAEL
760 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
2-Furanmethanol, tetrahydro-
BRN 0102723
EINECS 202-625-6
FEMA No. 3056
Tetrahydro-2-furfuryl alcohol
Tetrahydrofuryl carbinol
Tetrahydrofurylalkohol
UNII-XD95821VF9
Chemical Function
Solvent
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory Lists
banned; Europe; Personal care
inert_ingredient; non_food_use; Pesticides
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL2287521
Frequently Asked Questions
Is Tetrahydrofurfuryl Alcohol allowed in the EU?
Tetrahydrofurfuryl Alcohol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Tetrahydrofurfuryl Alcohol do in cosmetics?
Tetrahydrofurfuryl Alcohol functions as: Solvent, Fragrance. It is classified as a cosmetic ingredient in our database. CAS number: 97-99-4.
What is the NOAEL for Tetrahydrofurfuryl Alcohol?
The NOAEL (No Observed Adverse Effect Level) for Tetrahydrofurfuryl Alcohol is =39 mg/kg bw/day based on a chronic study via oral route in Rat. A total of 8 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Tetrahydrofurfuryl Alcohol classified as hazardous under GHS?
Tetrahydrofurfuryl Alcohol carries a GHS signal word of "WARNING". Hazard statements: Combustible liquid Causes serious eye irritation Suspected of damaging fertility or the unborn child. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Tetrahydrofurfuryl Alcohol used outside cosmetics?
Tetrahydrofurfuryl Alcohol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Tetrahydrofurfuryl Alcohol have different safety status in cosmetics vs industrial chemicals?
Tetrahydrofurfuryl Alcohol is classified GHS Danger (H319, H360, H227, H315, H336, H361, H373, H360Df) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Tetrahydrofurfuryl Alcohol compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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