Good Cosmetic Ingredient NOAEL Data

Styralyl Alcohol

Also known as: 1-Phenylethanol (alpha-Methylbenzyl alcohol) (Benzenemethanol, .alpha.-methyl-), Benzenemethanol, .alpha.-methyl-, Benzenemethanol, alpha-methyl-, EINECS 202-707-1, EINECS 236-361-8 (+15 more)

INCI: STYRALYL ALCOHOL (Α-METHYLBENZYL ALCOHOL; 1-PHENYLETHANOL)

Styralyl Alcohol (CAS 98-85-1) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient, solvent. NOAEL 15.6333 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.

View industrial chemical safety profile for CAS 98-85-1 →

Auto-generated CPSR Part A draft with source citations

Cross-Vertical Regulatory Divergence

Styralyl Alcohol is classified GHS Danger (H302, H319, H315, H318, H335) in the chemicals database but is allowed in EU cosmetics.

Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

CAS Number

98-85-1

View industrial chemical safety profile →

Function

Fragrance ingredient, solvent

Safety Rating

GOOD

Chemistry & Identifiers

Formula

C8H10O

122.16 g/mol

EC Number

202-707-1

PubChem CID

7409

IUPAC Name

1-phenylethanol

InChIKey

WAPNOHKVXSQRPX-UHFFFAOYSA-N

ChEBI: CHEBI:669 UNII: E6O895DQ52 Wikidata: Q3740715

Regulatory Status

EU EU Status permitted

US US Status permitted

US Notes GRAS for flavoring (FEMA); permitted in cosmetics

For full compliance data across multiple jurisdictions, use the Substance Compliance tool.

Safety Data

Margin of Safety, dermal absorption, and sensitization profile summaries for Styralyl Alcohol.

Calculate MoS for your specific formulation with the MoS Calculator.

Toxicological Studies

7 study endpoints found for Styralyl Alcohol. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.

Endpoint	Value	Route	Species	Study Type	Source
NOAEL	375 mg/kg bw/day	oral	mouse	Subchronic	COSMOS_DB
NOAEL	=43 mg/kg bw/day	dermal	Rat	reproduction developmental	ToxValDB_ECHA_IUCLID
NOAEL	=70 mg/kg bw/day	dermal	Rat	reproduction developmental	ToxValDB_ECHA_IUCLID
NOAEL	=140 mg/kg bw/day	dermal	Rat	reproduction developmental	ToxValDB_ECHA_IUCLID
NOAEL	=430 mg/kg bw/day	dermal	Rat	reproduction developmental	ToxValDB_ECHA_IUCLID
NOAEL	=500 mg/kg bw/day	oral	Mouse	short-term	ToxValDB_ECHA_IUCLID
NOAEL	=1000 mg/kg bw/day	oral	Rat	short-term	ToxValDB_ECHA_IUCLID

Pre-Calculated Safety Assessment

Pre-calculated NOAEL → SED → MoS audit trail for Styralyl Alcohol across SCCS product categories, with measured dermal absorption where available.

Sensitization AOP Dashboard

Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.

NESIL

5184 µg/cm²

GHS: 1B Human: positive

Source: HPPT: [42] Kligman AM (1973): Report to RIFM, 9 October, unpublished.

HRIPT Human Patch Test Studies

2 human repeat insult patch tests aggregated from dermatological literature.

Test Type	N	Sensitized	Dose µg/cm²	NESIL µg/cm²	Potency
HMT	-	0	5184	-	-
HMT	-	0	5184	-	-

ECHA REACH Registration

European Chemicals Agency REACH dossier and Substances of Very High Concern listing.

Registration Type

Full

Tonnage Band

1 - 10 tonnes

Substance Type

SUBSTANCE; GROUP

SVHC Candidate

PubChem Annotations

Safety and regulatory annotations from PubChem (NCBI) aggregated sources.

Safety (1)

Carcinogen Classification

Alpha-Methylbenzyl Alcohol | TR-369: Toxicology and Carcinogenesis Studies of alpha-Methylbenzyl Alcohol (CASRN 98-85-1) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (1990 ) | 03/13/89 | Some Evidence | No Evidence | No Evidence | No Evidence | Under the conditions of these 2-year gavage studies, there was some evidence of carcinogenic activity of a-methylbenzyl alcohol for male F344/N

Source: NTP Technical Reports

Regulatory (6)

JECFA Number

799