Is Sodium 5-Nitroguaiacolate safe in cosmetics?
Sodium 5-Nitroguaiacolate has a safety rating of "POOR" in our database. EU status: permitted. US status: permitted. 1 toxicological study endpoint(s) are available in our database.
Sodium 5-Nitroguaiacolate
Also known as: Phenol, 2-methoxy-5-nitro-, sodium salt, 5-Nitroguaiacol sodium salt, Sodium 2-methoxy-5-nitrophenoxide, EPA Pesticide Chemical Code 129075, Atonik G (+2 more)
INCI: ⛔ NO COSMETIC INCI ASSIGNED — NOT A COSMETIC INGREDIENT
Sodium 5-Nitroguaiacolate (CAS 67233-85-6) is a cosmetic cosmetic ingredient functioning as Plant growth regulator (commercial name: Atonik); EPA-registered pesticide. Reported NOAEL =300 mg/kg bw/day in Rat (EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 67233-85-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Sodium 5-Nitroguaiacolate is classified GHS Danger (H302, H319, H242, H318, H411) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Plant growth regulator (commercial name: Atonik); EPA-registered pesticide
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
sodium 2-methoxy-5-nitrophenolate
InChIKey
KBRKFTKQRMYINW-UHFFFAOYSA-M
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
EPA Pesticide Chemical Code 129075 — regulated as pesticide, NOT cosmetic
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Sodium 5-Nitroguaiacolate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
1 study endpoint found for Sodium 5-Nitroguaiacolate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =300 mg/kg bw/day | - | Rat | reproduction toxicity | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for Sodium 5-Nitroguaiacolate.
Regulatory Flags
natural-origin
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Sodium 5-Nitroguaiacolate by CAS number or substance name.
Studies
1
Lowest NOAEL
300 mg/kg bw/day
Highest NOAEL
300 mg/kg bw/day
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
Known Synonyms
Phenol, 2-methoxy-5-nitro-, sodium salt
5-Nitroguaiacol sodium salt
Sodium 2-methoxy-5-nitrophenoxide
EPA Pesticide Chemical Code 129075
Atonik G
2-Methoxy-5-nitrophenol sodium salt
UNII-A1RBP9328O
Chemical Function
Dye
Regulatory Lists
active_ingredient; Europe; Pesticides
active_ingredient; Europe; Pesticides
Frequently Asked Questions
Is Sodium 5-Nitroguaiacolate allowed in the EU?
Sodium 5-Nitroguaiacolate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Sodium 5-Nitroguaiacolate do in cosmetics?
Sodium 5-Nitroguaiacolate functions as: Plant growth regulator (commercial name: Atonik); EPA-registered pesticide. It is classified as a cosmetic ingredient in our database. CAS number: 67233-85-6.
What is the NOAEL for Sodium 5-Nitroguaiacolate?
The NOAEL (No Observed Adverse Effect Level) for Sodium 5-Nitroguaiacolate is =300 mg/kg bw/day based on a reproduction toxicity study via oral route in Rat. Source: EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx.
Is Sodium 5-Nitroguaiacolate used outside cosmetics?
Sodium 5-Nitroguaiacolate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Sodium 5-Nitroguaiacolate have different safety status in cosmetics vs industrial chemicals?
Sodium 5-Nitroguaiacolate is classified GHS Danger (H302, H319, H242, H318, H411) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
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Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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