Is Rhamnose safe in cosmetics?
Rhamnose has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Active Ingredient
Rhamnose
Also known as: Isodulcit, Isodulcitol, L-Mannomethylose, Locaose, MANNOSE (L), 6-DEOXY- (+11 more)
INCI: RHAMNOSE
Rhamnose (CAS 3615-41-6) is a cosmetic active ingredient functioning as Humectant, Masking, Anti-Aging Active. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 3615-41-6 →
Auto-generated CPSR Part A draft with source citations
Function
Humectant, Masking, Anti-Aging Active
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(3R,4R,5R,6S)-6-methyloxane-2,3,4,5-tetrol
InChIKey
SHZGCJCMOBCMKK-JFNONXLTSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific FDA restrictions.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Rhamnose.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
4 property records from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "barrier-repair, prebiotic", "mechanism_of_action": "Microbiome modulation, barrier support", "target_skin_layer": "stratum corneum, epidermis", "collagen_stimulation": "No", "elastin_protection": "No", "wrinkle_reduction_pct": "6-12", "clinical_study_duration_weeks": "8", "sample_size": "30", "double_blind": "No", "placebo_controlled": "Yes", "published_journal": "Microbiome …
biopolymer
{"cas_number": "3615-41-6", "polymer_class": "other", "botanical_source": "Plant polysaccharides (monosaccharide)", "molecular_weight_range_kDa": "0.164", "monosaccharide_composition": "L-rhamnose", "degree_of_branching": "not_applicable", "charge_type": "nonionic", "viscosity_1pct_solution_mPas": "1-5", "pseudoplastic_behavior": "Newtonian", "thixotropy": "no", "yield_stress_Pa": "0", "gel_formin…
cost_pricing
{"cost_tier": "premium", "estimated_cost_per_kg_usd_low": "95", "estimated_cost_per_kg_usd_high": "180", "natural_premium_markup_pct": "0", "organic_certified_premium_pct": "0", "supply_chain_volatility": "low", "primary_source_region": "France", "bulk_discount_threshold_kg": "10", "seasonal_price_variation": "low", "commodity_or_specialty": "specialty", "substitute_ingredients": "Trehalose, Sugar…
skin_suitability
{"oily_skin": "acceptable", "dry_skin": "acceptable", "sensitive_skin": "acceptable", "combination_skin": "acceptable", "normal_skin": "acceptable", "acne_prone": "acceptable", "rosacea": "acceptable", "eczema": "acceptable", "hyperpigmentation": "acceptable", "aging_mature": "recommended", "dehydrated": "acceptable", "skin_benefit_primary": "anti-aging", "skin_benefit_secondary": "firming", "mech…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Humectant
Regulatory List Membership (1)
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Rhamnose.
Regulatory Flags
fda_food_additive
Known Synonyms
Isodulcit
Isodulcitol
L-Mannomethylose
Locaose
MANNOSE (L), 6-DEOXY-
NSC 2056
Rhamnose, L-
L-(+)-Rhamnose
EC No.: 222-793-4
EINECS 222-793-4
FEMA No. 3730
Mannomethylose, L-
UNII-QN34XC755A
(2R,3R,4S,5S)-2,3,4,5-tetrahydroxyhexanal
L-Rha
aldehydo-L-rhamnose
Chemical Function
Humectant
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
L-RHAMNOSE
Food Category
flavoring
Frequently Asked Questions
Is Rhamnose allowed in the EU?
Rhamnose EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Rhamnose do in cosmetics?
Rhamnose functions as: Humectant, Masking, Anti-Aging Active. It is classified as a Active Ingredient in our database. CAS number: 3615-41-6.
Is Rhamnose used outside cosmetics?
Rhamnose also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Rhamnose compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
Acetyl Tetrapeptide-5
Excellent
Same category
Anti-edema peptide for periorbital ar...
Activated Charcoal
Excellent
Same category
Adsorbent; skin cleanser; pore-cleans...
Adenosine
Excellent
Same category
Skin-conditioning agent, anti-aging, ...
Allantoin
Excellent
Same category
Skin conditioner, keratolytic, anti-i...
Alpha-Glucan Oligosaccharide
Excellent
Same category
prebiotic, skin-conditioning
Ascophyllum Nodosum Extract
Excellent
Same category
Skin Brightening, Tyrosinase Inhibito...
(AGARICUS BLAZEI FERMENT + GANODERMA LUCIDUM FERMENT + GANODERMA MULTIPILEUM FERMENT) EXTRACT
Good
Similar safety
Anti-sebum, Antioxidant, Skin Protecting
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA) ROOT/CNIDIUM OFFICINALE RHIZOME EXTRACT
Good
Similar safety
Skin Conditioning, Skin Conditioning ...
(ANGELICA ACUTILOBA/PAEONIA LACTIFLORA/REHMANNIA GLUTINOSA/SCUTELLARIA BAICALENSIS) ROOT/(CNIDIUM OFFICINALE/COPTIS CHINENSIS) RHIZOME/GARDENIA JASMINOIDES FRUIT/PHELLODENDRON CHINENSE BARK EXTRACT
Good
Similar safety
(ANGELICA GIGAS/GLYCYRRHIZA URALENSIS/REHMANNIA GLUTINOSA ROOT)/ANGELICA GIGAS STEM/CARTHAMUS TINCTORIUS FLOWER/(CARTHAMUS TINCTORIUS/PRUNUS PERSICA SEED)PORIA COCOS WATER
Good
Similar safety
Humectant, Skin Conditioning, Skin Pr...
(ANGELICA KEISKEI/CHRYSANTHEMUM ZAWADSKII) LEAF/STEM/CINNAMOMUM CASSIA BARK/TRICHOSANTES KIRILOWII FRUIT/ULMUS DAVIDIANA BARK/ROOT/(PAEONIA JAPONICA/BUPLEURUM FALCATUM/POLYGALA TENUIFOLIA ROOT)/VISCUS ALBUM STEM EXTRACT
Good
Similar safety
Anti-seborrheic, Anti-sebum, Antioxid...
(APPLE/CITRUS JUNOS/LENTIL/PEAR/PUMPKIN/STRAWBERRY/TOMATO FRUIT)/CORN KERNEL/(ARCTIUM LAPPA/BRASSICA OLERACEA ACEPHALA/CABBAGE/CAMELLIA SINENSIS/MORINGA OLEIFERA/RADISH/SPINACH LEAF)/(SORGHUM BICOLOR LEAF/STEM)/OAT MEAL/POTATO PULP/(CARROT/NELUMBO NUCIFERA/RADISH/WILD YAM ROOT)/(AMARANTHUS HYPOCHONDRIACUS/CASHEW/CICER ARIETINUM/COIX LACRYMA-JOBI MA-YUEN /MACADAMIA TERNIFOLIA/PHASEOLUS ANGULARIS/PISTACIA VERA/RHYNCHOSIA NULUBILIS/RICE/SESAME/SETARIA ITALICA/SOYBEAN/SWEET ALMOND/WHEAT SEED)/HORDEUM VULGARE SPROUT/CYPERUS ESCULENTUS TUBER/ARTEMISIA PRINCEPS/BROCCOLI/CHENOPODIUM QUINOA/ENTEROMORPHA COMPRESSA/HORDEUM VULGARE/IPOMOEA BATATAS/LAMINARIA JAPONICA/LENTINUS EDODES/PLEUROTUS OSTREATUS/PORPHYRA TENERA/UNDARIA PINNATIFIDA EXTRACT
Good
Similar safety
Antioxidant
Phytin
Good
Chemical family
Chelating agent
RHEUM PALMATUM ROOT EXTRACT
Good
Browse nearby
Astringent, Skin Conditioning, Tonic
RHIZOPUS/SACCHAROMYCES/ACANTHOPANAX SESSILIFLORUS BARK/CORN STARCH/(CORNUS OFFICINALIS/CRATAEGUS PINNATIFIDA/LYCIUM CHINENSE/SCHISANDRA CHINENSIS) FRUIT/HYDRANGEA SERRATA LEAF/(ASTRAGALUS MEMBRANACEUS/DIOSCOREA JAPONICA/GINGER/LICORICE/PANAX GINSENG) ROOT/PORIA COCOS/RICE FERMENT EXTRACT FILTRATE
Good
Browse nearby
Skin Conditioning, Skin Conditioning ...
Is Rhamnose in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Rhamnose in your formulation.