Is Resveratrol Dimethyl Ether (Pterostilbene) safe in cosmetics?
Resveratrol Dimethyl Ether (Pterostilbene) has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
Excellent
Cosmetic Ingredient
Resveratrol Dimethyl Ether (Pterostilbene)
Also known as: 3,5-Dimethoxy-4'-hydroxy-trans-stilbene, 4-Stilbenol, 3',5'-dimethoxy-, (E)-, 4-((E)-2-(3,5-Dimethoxyphenyl)ethenyl)phenol, (E)-1-hydroxy-4-(3,5-dimethoxy)styrylbenzene, (E)-3',5'-dimethoxy-4-stilbenol (+6 more)
INCI: RESVERATROL DIMETHYL ETHER
Resveratrol Dimethyl Ether (Pterostilbene) (CAS 537-42-8) is a cosmetic cosmetic ingredient functioning as Antioxidant, skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 537-42-8 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Resveratrol Dimethyl Ether (Pterostilbene) is classified GHS Danger (H318, H411) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Antioxidant, skin conditioning
Safety Rating
EXCELLENT
Chemistry & Identifiers
IUPAC Name
4-[(E)-2-(3,5-dimethoxyphenyl)ethenyl]phenol
InChIKey
VLEUZFDZJKSGMX-ONEGZZNKSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted; pterostilbene also has GRAS status for dietary supplements (FDA No Objection Letters exist)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Resveratrol Dimethyl Ether (Pterostilbene).
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Resveratrol Dimethyl Ether (Pterostilbene).
Known Synonyms
3,5-Dimethoxy-4'-hydroxy-trans-stilbene
4-Stilbenol, 3',5'-dimethoxy-, (E)-
4-((E)-2-(3,5-Dimethoxyphenyl)ethenyl)phenol
(E)-1-hydroxy-4-(3,5-dimethoxy)styrylbenzene
(E)-3',5'-dimethoxy-4-stilbenol
(E)-4'-hydroxy-3,5-dimethoxystilbene
3',5'-dimethoxy-4-stilbenol
3',5'-dimethoxy-resveratrol
4-(2-(3,5-Dimethoxyphenyl)ethenyl)phenol
4-[(E)-2-(3,5-dimethoxyphenyl)vinyl]phenol
trans-pterostilbene
Chemical Function
Antioxidant
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PTEROSTILBENE
ChEMBL ID
CHEMBL83527
Max Phase
2
Frequently Asked Questions
Is Resveratrol Dimethyl Ether (Pterostilbene) allowed in the EU?
Resveratrol Dimethyl Ether (Pterostilbene) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Resveratrol Dimethyl Ether (Pterostilbene) do in cosmetics?
Resveratrol Dimethyl Ether (Pterostilbene) functions as: Antioxidant, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 537-42-8.
Is Resveratrol Dimethyl Ether (Pterostilbene) used outside cosmetics?
Resveratrol Dimethyl Ether (Pterostilbene) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Resveratrol Dimethyl Ether (Pterostilbene) have different safety status in cosmetics vs industrial chemicals?
Resveratrol Dimethyl Ether (Pterostilbene) is classified GHS Danger (H318, H411) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Resveratrol Dimethyl Ether (Pterostilbene) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2-O-Ethyl Ascorbic Acid
Excellent
Same category
Softener and conditioner
3-Glyceryl Ascorbate
Excellent
Same category
Antioxidant, Humectant, Skin Conditio...
Allantoin Ascorbate
Excellent
Same category
Antioxidant, Skin Conditioning, Skin ...
Aloe Vera Extract
Excellent
Same category
Skin Conditioning, Antioxidant
Althaea Officinalis Callus Culture Extract
Excellent
Same category
Antioxidant, skin protectant
Amaranthus Caudatus Seed Oil
Excellent
Same category
Emollient, skin conditioning, antioxi...
1-Methylhydantoin-2-imide (Creatinine)
Excellent
Similar safety
Skin conditioning (skin brightening/l...
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Similar safety
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Similar safety
Fragrance (rich woody, orris/iris roo...
2-Hydroxypropylcarbamato Amodimethicone
Excellent
Similar safety
Hair conditioning; modified aminosili...
3 O Ethyl Ascorbic Acid
Excellent
Similar safety
Antioxidant; tyrosinase inhibitor; me...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Similar safety
Fragrance / Perfuming agent with flor...
4,4'-Diaminodiphenylamine
Poor
Chemical family
Hair Dye (oxidative)
Acetyl Tyrosine
Good
Chemical family
Skin Conditioning, Tanning Agent, Mel...
Pterostilbene
Good
Chemical family
Antioxidant, Skin Conditioning, Anti-...
Is Resveratrol Dimethyl Ether (Pterostilbene) in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Resveratrol Dimethyl Ether (Pterostilbene) in your formulation.