Is Red 27 Lake (CI 45410_1)__ safe in cosmetics?
Red 27 Lake (CI 45410_1)__ has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Red 27 Lake (CI 45410_1)__
Also known as: D & C Red No. 27, D&C red no.27, EINECS 236-747-6, C,I, Solvent Red 48, Japan Red 218
INCI: RED 27 LAKE (CI 45410_1)
Red 27 Lake (CI 45410_1)__ (CAS 13473-26-2) is a cosmetic colorant functioning as Colorant. Reported NOAEL =1000 mg/kg bw/day in Rat (ToxValDB_ECHA_IUCLID); EU Regulation 1223/2009 status: permitted, max 14.3%. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 13473-26-2 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant
Safety Rating
GOOD
Chemistry & Identifiers
EC Number
236-747-6
Regulatory Status
EU EU Status
permitted
EU Max Conc.
14.3%
US US Status
permitted
US Notes
CIR has reviewed D&C Red No. 27 and related xanthene dyes. The CIR Expert Panel concluded the ingredient is safe as used in cosmetic formulations.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Red 27 Lake (CI 45410_1)__.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Red 27 Lake (CI 45410_1)__. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =2000 mg/kg bw/day | oral | Mouse | reproduction developmental | ToxValDB_ECHA_IUCLID |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| BR | permitted_colorant | - | Column 2: All products except eye area |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Dye
Expert Verdict
Expert safety assessment and concern-level summary for Red 27 Lake (CI 45410_1)__.
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Red 27 Lake (CI 45410_1)__ by CAS number or substance name.
Studies
2
Lowest NOAEL
1000 mg/kg bw/day
Highest NOAEL
2000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Known Synonyms
D & C Red No. 27
D&C red no.27
EINECS 236-747-6
C,I, Solvent Red 48
Japan Red 218
Chemical Function
Dye
Regulatory Lists
pharmaceutical
Personal care
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1580759
Frequently Asked Questions
Is Red 27 Lake (CI 45410_1)__ allowed in the EU?
Red 27 Lake (CI 45410_1)__ EU regulatory status: permitted. Maximum allowed concentration: 14.3%. This is based on EU Regulation 1223/2009 and its amendments.
What does Red 27 Lake (CI 45410_1)__ do in cosmetics?
Red 27 Lake (CI 45410_1)__ functions as: Colorant. It is classified as a Colorant in our database. CAS number: 13473-26-2.
What is the NOAEL for Red 27 Lake (CI 45410_1)__?
The NOAEL (No Observed Adverse Effect Level) for Red 27 Lake (CI 45410_1)__ is =1000 mg/kg bw/day based on a reproduction developmental study via oral route in Rat. A total of 2 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is Red 27 Lake (CI 45410_1)__ used outside cosmetics?
Red 27 Lake (CI 45410_1)__ also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Red 27 Lake (CI 45410_1)__ compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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