Is CI 77491 (Red Iron Oxide) safe in cosmetics?
CI 77491 (Red Iron Oxide) has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: permitted.
CI 77491 (Red Iron Oxide)
Also known as: Iron(III) oxide, C.I. Pigment Red 102, C.I. Pigment Red 101 and 102, Anchred standard, Anhydrous iron oxide (+15 more)
INCI: CI 77491
CI 77491 (Red Iron Oxide) (CAS 1309-37-1) is a cosmetic colorant functioning as Colorant. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1309-37-1 →
Auto-generated CPSR Part A draft with source citations
Function
Colorant
Safety Rating
EXCELLENT
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Regulated under 21 CFR 73.2250 as a listed color additive. Permitted in all cosmetics including eye-area products. Exempt from FDA batch certification. No numerical concentration limit — use per GMP. Must be synthetically prepared; naturally mined iron oxides prohibited. Verify heavy metal specs (As, Pb, Hg) on CoA.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for CI 77491 (Red Iron Oxide).
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
May cause mechanical irritation.
Long-term Exposure Effects
Repeated or prolonged inhalation of dust particles may cause effects on the lungs. This may result in siderosis, a benign condition.
EPA ToxValDB — Toxicity Values
4 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| LD50 | >10000 mg/kg | Rat | oral | - | ECHA IUCLID |
| LD50 | =250.54 mg/kg | Rat | injection | - | ECHA IUCLID |
| LD50 | =5500 mg/kg | Rat | injection | - | ECHA IUCLID |
| NOAEL | >1000 mg/kg-day | Rat | oral | subchronic | ECHA IUCLID |
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
1, Sup 7
Evaluation Year
1987
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE; GROUP
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (4)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | - | All cosmetics (Class 1) |
| BR | permitted_colorant | - | Column 1: All products |
| ASEAN | permitted_colorant | - | All products |
| ASEAN | permitted_colorant | - | All products |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
colorant
{"Common_Name": "Iron Oxide Red (micronized)", "Chemical_Name": "Iron oxide (<0.5μm)", "CAS_Number": "1309-37-1", "Colorant_Type": "Inorganic Pigment", "Approved_Uses": "All cosmetics", "Max_Concentration_%": "No limit", "EU_Status": "Approved", "US_FDA_Status": "Approved", "Notes": "Ultra-fine for transparency"}
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Binder
Degradant/impurity
Dye
Filler
Flux agent
Pigment
Processing aids not otherwise specified
Regulatory List Membership (5)
EU Regulated in Personal Care
EU Restricted for Children (Cosmetics)
FDA Substances Added to Food (EAFUS)
FDA Indirect Food Contact Additives
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for CI 77491 (Red Iron Oxide).
Regulatory Flags
nano-form-inconclusive
impurity-control-critical
eye-area-approved
no-concentration-limit
fda-batch-cert-exempt
genotoxicity-signal-oral-context-only
eu_children_restricted
fda_food_additive
eu_cosing_listed
Known Synonyms
Iron(III) oxide
C.I. Pigment Red 102
C.I. Pigment Red 101 and 102
Anchred standard
Anhydrous iron oxide
Anhydrous oxide of iron
Armenian bole
Bauxite residue
Black oxide of iron
Blended red oxides of iron
Burnt sienna
Burnt umber
Burntisland Red
Calcotone Red
Crocus martis adstringens
Deanox DNX Pigments
EINECS 215-168-2
Eisenoxyd
Hematite mineral
Indian red
Chemical Function
Dye
Pigment
Binder
Regulatory Lists
Indirect additives food contact (10/2018)
children; Europe; Personal care
children; Europe; Personal care - specialized bath products - bath salts
children; Europe; Personal care - dental care - toothpaste
children; Europe; Personal care
Europe; Personal care
Europe; Personal care
Europe; Personal care
consumer_product; Europe
Europe; plastic_additive
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
Canada; consumer_product; Substances in Products - Canada (4/2014)
inert_ingredient; Pesticides
inert_ingredient; Pesticides
inert_ingredient; non_food_use; Pesticides
Europe; Personal care
Arts and crafts/Office supplies - body paint - tattoo ink; Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
ferric oxide
ChEMBL ID
CHEMBL2108514
Adverse Event Associations
14
Frequently Asked Questions
Is CI 77491 (Red Iron Oxide) allowed in the EU?
CI 77491 (Red Iron Oxide) EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does CI 77491 (Red Iron Oxide) do in cosmetics?
CI 77491 (Red Iron Oxide) functions as: Colorant. It is classified as a Colorant in our database. CAS number: 1309-37-1.
Is CI 77491 (Red Iron Oxide) used outside cosmetics?
CI 77491 (Red Iron Oxide) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check CI 77491 (Red Iron Oxide) compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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