Also known as: Prussian blue, CI 77510 Blue, Iron ferrocyanide (Fe4[Fe(CN)6]3), EC No.: 237-875-5, EINECS 237-875-5 (+12 more)
INCI: CI 77510
Ferric Ferrocyanide (Prussian Blue) (CAS 14038-43-8) is a cosmetic colorant functioning as Colorant (blue). Reported NOAEL =25 mg/kg bw/day in rat (2207; male/female) (FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z); EU Regulation 1223/2009 status: permitted, max Must be free from cyanide ions (purity condition). Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 14038-43-8 →
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Margin of Safety, dermal absorption, and sensitization profile summaries for Ferric Ferrocyanide (Prussian Blue).
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5 study endpoints found for Ferric Ferrocyanide (Prussian Blue). NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =25 mg/kg bw/day | oral: feed | rat (2207; male/female) | repeated dose toxicity oral | FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z |
| NOAEL | =25 mg/kg bw/day | oral: feed | rat (2207; male/female) | repeated dose toxicity oral | FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z |
| NOAEL | =25 mg/kg bw/day | oral: feed | rat (2207; male/female) | repeated dose toxicity oral | FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z |
| NOAEL | =25 mg/kg bw/day | oral: feed | rat (2207; male/female) | repeated dose toxicity oral | FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z |
| NOAEL | =25 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | permitted_colorant | - | All cosmetics (Class 1) |
| BR | permitted_colorant | - | Column 2: All products except eye area |
1 property record from structured ingredient metadata.
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Expert safety assessment and concern-level summary for Ferric Ferrocyanide (Prussian Blue).
Public NOAEL study rows linked to Ferric Ferrocyanide (Prussian Blue) by CAS number or substance name.
Same-CAS public records found in pharmaceutical data.
Same-CAS rows from the pharmaceutical spoke database.
Ferric Ferrocyanide (Prussian Blue) has a safety rating of "EXCELLENT" in our database. EU status: permitted. US status: restricted. 5 toxicological study endpoint(s) are available in our database.
Ferric Ferrocyanide (Prussian Blue) EU regulatory status: permitted. Maximum allowed concentration: Must be free from cyanide ions (purity condition). This is based on EU Regulation 1223/2009 and its amendments.
Ferric Ferrocyanide (Prussian Blue) functions as: Colorant (blue). It is classified as a Colorant in our database. CAS number: 14038-43-8.
The NOAEL (No Observed Adverse Effect Level) for Ferric Ferrocyanide (Prussian Blue) is =25 mg/kg bw/day based on a repeated dose toxicity oral study via oral: feed route in rat (2207; male/female). A total of 5 study endpoints are available. Source: FDA_Toxicity_3333babf-4063-428b-a866-15ba9c3f3873_dossier.i6z.
Ferric Ferrocyanide (Prussian Blue) also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
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