What is the NOAEL for D&C Red 27?
D&C Red 27 has 7 NOAEL studies in the database. The lowest reported value is 2LRS185U6K UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
D&C Red 27
Also known as: D & C Red No. 27, D&C red no.27, EINECS 236-747-6, C,I, Solvent Red 48, Japan Red 218
CAS 13473-26-2
D&C Red 27 (CAS 13473-26-2) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, SCCS, ECHA REACH.
View cosmetic safety profile for Red 27 Lake (CI 45410_1)__ →
SOURCE
noael studies public
NOAEL studies
7
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
11 fields
Name
D&C Red 27
CAS Number
13473-26-2
DTXSID
DTXSID2031089
Molecular Formula
C20H4Br4Cl4O5
InChI Key
ZYIBVBKZZZDFOY-UHFFFAOYSA-N
Monoisotopic Mass
779.554634
Synonyms
D & C Red No. 27D&C red no.27EINECS 236-747-6C,I, Solvent Red 48Japan Red 218
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Dye
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
| Personal care | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 7 of 7 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2LRS185U6K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2LRS185U6K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2LRS185U6K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2LRS185U6K | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =2000 | mg/kg bw/day | LOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =2000 | mg/kg bw/day | NOAEL | oral | Mouse | ToxValDB_ECHA_IUCLID |
Showing 7 of 7 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-[9H]xanthene]-3-one | 236-747-6 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
SCCS Opinions
EU Scientific Committee opinions tied to the matched substance.
SOURCE
EU SCCS
1 opinions
| Opinion | Date | Conclusion | Max Conc. | Concerns |
|---|---|---|---|---|
| SCCP/1120/07 | 18 December 2007 | safe | 1.0% | secondary amine; nitrosamine <50ppb; sensitisation not excluded |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
14.3%
Category
colorant
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
CHEMBL1580759
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
1
Frequently Asked Questions
What regulatory lists include D&C Red 27?
D&C Red 27 appears on 2 regulatory/inventory lists including pharmaceutical, Personal care. Source: EPA CPDat.
Is D&C Red 27 used in cosmetics?
Yes, D&C Red 27 is also indexed as a cosmetic ingredient under the name Red 27 Lake (CI 45410_1)__. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for D&C Red 27 come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Is D&C Red 27 used outside industrial chemicals?
D&C Red 27 also appears in cosmetics, pharmaceutical databases.