Is Raspberry Ketone safe in cosmetics?
Raspberry Ketone has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Raspberry Ketone
Also known as: 2-Butanone, 4-(4-hydroxyphenyl)-, BRN 0776080, EINECS 226-806-4, FEMA No. 2588, Frambinone (+14 more)
INCI: RASPBERRY KETONE
Raspberry Ketone (CAS 5471-51-2) is a cosmetic cosmetic ingredient functioning as Fragrance, Skin conditioning. NOAEL 45 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 5471-51-2 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance, Skin conditioning
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
4-(4-hydroxyphenyl)butan-2-one
InChIKey
NJGBTKGETPDVIK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted – GRAS as food flavoring (21 CFR); INCI name recognized; no specific cosmetic restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Raspberry Ketone.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Raspberry Ketone. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 100 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | =280 mg/kg bw/day | - | Unspecified | subchronic | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Raspberry Ketone across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 7776 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Additional Ingredient Properties
1 property record from structured ingredient metadata.
fragrance_ifra
{"cas_number": "5471-51-2", "ifra_amendment_number": "49", "ifra_restriction_type": "Restricted", "ifra_max_use_level_category_1_pct": "0.095", "ifra_max_use_level_category_4_pct": "1.5", "ifra_max_use_level_category_7_pct": "0.22", "ifra_max_use_level_category_11_pct": "0.042", "eu_allergen_declaration_required": "No", "eu_26_allergens_list": "No", "sccs_opinion_available": "Yes", "sensitization_…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Skin Eye Respiratory Irritation
...Tested at 12% in petrolatum, it produced no irritation after a 48-hr closed-patch test on human subjects.
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (4)
JECFA Number
728
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
RASPBERRY KETONE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
4-(p-HYDROXYPHENYL)-2-BUTANONE | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
OXYPHENYLON | 2000 | No safety concern at current levels of intake when used as a flavouring agent | TRS 901-JECFA 55/44 | FAS 46-JECFA 55/165
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Softener and conditioner
Regulatory List Membership (4)
IFRA Fragrance Transparency List
EPA Safer Chemical Ingredients List (SCIL)
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Raspberry Ketone.
Regulatory Flags
potential-allergen
fragrance-component
epa_safer_alternative
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Raspberry Ketone by CAS number or substance name.
Studies
2
Lowest NOAEL
100 mg/kg bw/day
Highest NOAEL
280 mg/kg bw/day
COSMOS_DB
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx
Known Synonyms
2-Butanone, 4-(4-hydroxyphenyl)-
BRN 0776080
EINECS 226-806-4
FEMA No. 2588
Frambinone
Hydroxyphenylbutanone, p-
NSC 26515
Oxyphenalon
Rasketone
Rheosmin
UNII-7QY1MH15BG
(p-Hydroxybenzyl)acetone
1-(4-Hydroxyphenyl)-3-butanone
1-(p-Hydroxyphenyl)-3-butanone
4-(3-Oxobutyl)phenol
4-(4-Hydroxyphenyl)-2-butanone
4-(p-Hydroxyphenyl)-2-butanone
4-Hydroxybenzylacetone
p-Hydroxybenzyl acetone
Chemical Function
Deodorizer
Softener and conditioner
Fragrance
Flavouring and nutrient
Regulatory Lists
SCIL (9/2019)
artificial_saliva; detected; emissions; Europe; Toys and children's products
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe
detected; Toys and children's products
detected; Toys and children's products
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
RASPBERRYKETONE
ChEMBL ID
CHEMBL105912
Adverse Event Associations
16
Frequently Asked Questions
Is Raspberry Ketone allowed in the EU?
Raspberry Ketone EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Raspberry Ketone do in cosmetics?
Raspberry Ketone functions as: Fragrance, Skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 5471-51-2.
What is the NOAEL for Raspberry Ketone?
The NOAEL (No Observed Adverse Effect Level) for Raspberry Ketone is 100 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 2 study endpoints are available. Source: COSMOS_DB.
Is Raspberry Ketone used outside cosmetics?
Raspberry Ketone also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Raspberry Ketone compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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