NOAEL Studies Cosmetic Ingredient

Raspberry Ketone NOAEL Studies

INCI: RASPBERRY KETONE

CAS: 5471-51-2

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 100 mg/kg bw/day rat oral 91 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =128 mg/kg bw/day Rat oral: feed 91 days subchronic EFSA FEEDAP - 2016 - OutputID 2863 - organ weights - systemic - Safety and efficacy of aromatic ketones, secondary alcohols and related esters belonging to chemical group 21 when used as flavourings for all animal species - doi:10.2903/j.efsa.2016.4557
EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx NOAEL =280 mg/kg bw/day Unspecified - 91 days subchronic EFSA AFC - 2008 - OutputID 2254 - Flavouring Group Evaluation 58 (FGE.58): Consideration of phenol derivatives evaluated by JECFA (55th meeting) structurally related to ring substituted phenolic substances evaluated by EFSA in FGE.22 (2006) (Commission Regulation (EC) No 1565/2000 of 18 July 2000). Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission - doi:10.2903/j.efsa.2008.711
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =1320 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_7554; row=9353; data_type=In Vivo; mixture=Chemical; chemical_name=4-(4-Hydroxyphenyl)butan-2-one; preferred_name=4-(4-Hydroxyphenyl)butan-2-one; dtxsid=DTXSID5044495; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5044495; source_file=acute_oral.xlsx
NTP_ICE_adme_parameters 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_adme_parameters Clint 29.1 uL/min/10^6 cells Human - - Measured; httk, Human Hepatic Intrinsic Clearance sheet=Data; excel_row=2189; Record_ID=adme_parameters_863; Data_Type=Measured; DTXSID=DTXSID5044495; Assay=httk, Human Hepatic Intrinsic Clearance; Endpoint=Clint; Response=29.1; Response_Unit=ul/min/10^6 cells; Species=Human; Reference=httk2.3.1, Wambaugh 2019; URL=https://cran.r-project.org/web/packages/httk/index.html; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5044495
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8066; Record_ID=skin_sensitization_invivo_1821; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5044495; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80113-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5044495
NTP_ICE_skin_sensitization Induction dose per skin area 7776 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8064; Record_ID=skin_sensitization_invivo_1821; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5044495; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=7776; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80113-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5044495
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=8070; Record_ID=skin_sensitization_invivo_1821; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=12.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID5044495; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1978; Not available; 10.1016/S0015-6264(78)80113-8; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID5044495
ToxValDB_EFSA 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_EFSA LEL =250 mg/kg bw/day Chicken oral subchronic; 36 days subchronic LONG_REF=EFSA FEEDAP (2020). Safety of 31 flavouring compounds belonging to different chemical groups when used as feed additives for all animal species. doi:10.2903/j.efsa.2020.6338.; TITLE=Safety of 31 flavouring compounds belonging to different chemical groups when used as feed additives for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2020.6338; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2020; ORIGINAL_YEAR=2020; TOXICOLOGICAL_EFFECT=no effects; STUDY_GROUP=EFSA:15621600:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_3a8b0d25c515c5e77b9611f77bbd3dcf
ToxValDB_EFSA NOAEL =128 mg/kg bw/day Rat oral subchronic; 13 weeks subchronic LONG_REF=EFSA FEEDAP (2016). Safety and efficacy of aromatic ketones, secondary alcohols and related esters belonging to chemical group 21 when used as flavourings for all animal species. doi:10.2903/j.efsa.2016.4557.; TITLE=Safety and efficacy of aromatic ketones, secondary alcohols and related esters belonging to chemical group 21 when used as flavourings for all animal species; AUTHOR=EFSA FEEDAP; DOI=doi:10.2903/j.efsa.2016.4557; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65201d30e4b0f0a60ddd1165; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://zenodo.org/record/5076033#.Y9fEoXbMI2z; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=organ weight; TOXICOLOGICAL_EFFECT_CATEGORY=organ weight; STUDY_GROUP=EFSA:15621597:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bf8b195a351804d386aeef9a13a281fd
ToxValDB_GESTIS_DNEL 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_GESTIS_DNEL DNEL systemic =114.24 mg/m3 Human inhalation - Toxicity Value STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15632737:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_25cf86b5325a87350abcf8b5bcf23800
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 7QY1MH15BG UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7QY1MH15BG"}
openFDA substances FDA UNII substance identifier 7QY1MH15BG UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7QY1MH15BG"}
openFDA substances FDA UNII substance identifier 7QY1MH15BG UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7QY1MH15BG"}
openFDA substances FDA UNII substance identifier 7QY1MH15BG UNII - - - chemical {"approval_status":null,"molecular_formula":"C10H12O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"7QY1MH15BG"}