What is the NOAEL for 4-(4-Hydroxyphenyl)butan-2-one?
4-(4-Hydroxyphenyl)butan-2-one has 15 NOAEL studies in the database. The lowest reported value is 29.1 uL/min/10^6 cells in Human. Source: NTP_ICE_adme_parameters.
NOAEL Data
REACH Registered
Cosmetic Ingredient
4-(4-Hydroxyphenyl)butan-2-one
Also known as: 2-Butanone, 4-(4-hydroxyphenyl)-, Raspberry ketone, BRN 0776080, EINECS 226-806-4, FEMA No. 2588 (+15 more)
CAS 5471-51-2
4-(4-Hydroxyphenyl)butan-2-one (CAS 5471-51-2) is a chemical substance. Key regulatory status: REACH registered, 8 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
15
SOURCE
chemical inventory jurisdictions
Regulatory lists
8
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
26 fields
Name
4-(4-Hydroxyphenyl)butan-2-one
CAS Number
5471-51-2
DTXSID
DTXSID5044495
Molecular Formula
C10H12O2
InChI Key
NJGBTKGETPDVIK-UHFFFAOYSA-N
Monoisotopic Mass
164.08373
Synonyms
2-Butanone, 4-(4-hydroxyphenyl)-Raspberry ketoneBRN 0776080EINECS 226-806-4FEMA No. 2588FrambinoneHydroxyphenylbutanone, p-NSC 26515OxyphenalonRasketoneRheosminUNII-7QY1MH15BG
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
DeodorizerSoftener and conditionerFragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
8 records
| List | Keyword | Source |
|---|---|---|
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| artificial_saliva; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| Europe | European Commission | Fl@vis |
| detected; Toys and children's products | Springer Berlin Heidelberg | Published Articles |
| detected; Toys and children's products | Scientific Reports | Published Articles |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 15 of 15 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 29.1 | uL/min/10^6 cells | Clint | - | Human | NTP_ICE_adme_parameters |
| =114.24 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 7QY1MH15BG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7QY1MH15BG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7QY1MH15BG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 7QY1MH15BG | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 7776 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =1320 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =250 | mg/kg bw/day | LEL | oral | Chicken | ToxValDB_EFSA |
| 100 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| =128 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EFSA |
| =128 | mg/kg bw/day | NOAEL | oral: feed | Rat | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| =280 | mg/kg bw/day | NOAEL | - | Unspecified | EFSA_OpenFoodTox_EFSA_ReferencePoints.xlsx |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 15 of 15 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 4-(4-hydroxyphenyl)butan-2-one | 226-806-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
RASPBERRYKETONE
ChEMBL Phase
Not listed
Adverse Events
16
Bioactivity
1
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 4-(4-Hydroxyphenyl)butan-2-one?
4-(4-Hydroxyphenyl)butan-2-one appears on 7 regulatory/inventory lists including SCIL (9/2019), artificial_saliva; detected; emissions; Europe; Toys and children's products, IFRA Transparency, and 4 more. Source: EPA CPDat.
Is 4-(4-Hydroxyphenyl)butan-2-one used in cosmetics?
Yes, 4-(4-Hydroxyphenyl)butan-2-one is also indexed as a cosmetic ingredient under the name Raspberry Ketone. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 4-(4-Hydroxyphenyl)butan-2-one come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 4-(4-Hydroxyphenyl)butan-2-one used outside industrial chemicals?
4-(4-Hydroxyphenyl)butan-2-one also appears in cosmetics, pharmaceutical, cannabis databases.