PVP (CAS 9003-39-8) is a cosmetic cosmetic ingredient functioning as film-forming, adhesion promoter, hair-fixative. Reported NOAEL 5000 mg/kg bw/day in rat (COSMOS_DB); EU Regulation 1223/2009 status: permitted.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Margin of Safety, dermal absorption, and sensitization profile summaries for PVP - available to Pro subscribers.
Calculate MoS for your specific formulation with the MoS Calculator.
10 study endpoints found for PVP. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| NOAEL | 2500 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| NOAEL | 4000 mg/kg bw/day | oral | dog | Short Term Toxicity | COSMOS_DB |
| NOAEL | 4800 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| NOAEL | 10000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 5000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
| dose_tested | 2500 mg/kg bw/day | oral | dog | Chronic | COSMOS_DB |
| dose_tested | 4000 mg/kg bw/day | oral | dog | Short Term Toxicity | COSMOS_DB |
| dose_tested | 4800 mg/kg bw/day | oral | dog | Subchronic | COSMOS_DB |
| dose_tested | 10000 mg/kg bw/day | oral | rat | Short Term Toxicity | COSMOS_DB |
Pre-calculated NOAEL → SED → MoS audit trail for PVP across SCCS product categories, with measured dermal absorption where available.
5 toxicity values from EPA ToxValDB (aggregated from CCTE, HPV, ToxRefDB, IRIS, and other regulatory dossiers).
| Endpoint | Value | Species | Route | Duration | Source |
|---|---|---|---|---|---|
| ADI | <=50 mg/kg | Human | oral | - | WHO JECFA ADI |
| LD50 | =100000 mg/kg | Guinea Pig | oral | - | ChemIDplus |
| LD50 | >40000 mg/kg | Mouse | oral | - | ChemIDplus |
| LD50 | =1040 mg/kg | Rabbit | oral | - | ChemIDplus |
| LD50 | =100000 mg/kg | Rat | oral | - | ChemIDplus |
International Agency for Research on Cancer (WHO) monograph evaluation.
Reported concentration ranges per product category from SCCS/CIR/industry sources.
| Product Category | Typical Range | Max Reported | Source |
|---|---|---|---|
| Hair Spray | 5–10 | 15 | CIR/VCRP |
| Sunscreen | 0.5–2 | 5 | CIR/VCRP |
4 property records from structured ingredient metadata.
Expert safety assessment and concern-level summary for PVP - available to Pro subscribers.
PVP is permitted without restriction under EU Cosmetics Regulation 1223/2009 and not listed in any restrictive Annex. The CIR Expert Panel has affirmed safety in cosmetics with dermal absorption negligible for cosmetic-grade K-30, estimated MoS exceeding 2500, and all genotoxicity tests negative. The EU classifies PVP as "permitted". Safety rating: EXCELLENT. 10 toxicological study endpoint(s) are available in our database.
PVP EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
PVP functions as: film-forming, adhesion promoter, hair-fixative. It is classified as a cosmetic ingredient in our database. CAS number: 9003-39-8.
adequate The Margin of Safety (MoS) is calculated using SCCS methodology. A MoS above 100 is generally considered safe. Use the MoS Calculator tool to calculate MoS for your specific formulation and product category.
The NOAEL (No Observed Adverse Effect Level) for PVP is 5000 mg/kg bw/day based on a Short Term Toxicity study via oral route in rat. A total of 10 study endpoints are available. Source: COSMOS_DB.
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