What is the NOAEL for Polyvinylpyrrolidone?
Polyvinylpyrrolidone has 60 NOAEL studies in the database. The lowest reported value is 50 mg/kg via oral in Human. Source: ToxValDB_WHO_JECFA_ADI.
NOAEL Data
IARC Group 3
Cosmetic Ingredient
Polyvinylpyrrolidone
Also known as: K 115, Agrimer, Caswell No. 681, EPA Pesticide Chemical Code 079033, 1-Ethenyl-2-pyrrolidinone polymers (+15 more)
CAS 9003-39-8
Polyvinylpyrrolidone (CAS 9003-39-8) is a chemical substance; key hazard signal: IARC Group 3. Key regulatory status: 25 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC.
SOURCE
noael studies public
NOAEL studies
60
SOURCE
chemical inventory jurisdictions
Regulatory lists
25
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
23 fields
Name
Polyvinylpyrrolidone
CAS Number
9003-39-8
DTXSID
DTXSID0025941
Synonyms
K 115AgrimerCaswell No. 681EPA Pesticide Chemical Code 0790331-Ethenyl-2-pyrrolidinone polymersGanex p-804LuviskolLuviskol K30Luviskol K90NCI-C60582NSC 114022NSC 142693
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 3 | Not classifiable | 1998 | 19, Sup 7, 71 |
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
60 records
Film formerAnti-static agentViscosity modifierEmulsifierHair fixativeBinderFixing agent (mordant)Stabilizing agentDispersing agentFragrancePharmaceutical excipientThickening agent
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
25 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| inert_ingredient; non_food_use; Pesticides | EPA | CPCat |
| active_ingredient; Australia | Australian Pesticides and Veterinary Medicines Authority | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| drinking_water; Europe; manufacturing; plastic_additive | Belgaqua | CPCat |
| inert_ingredient; Pesticides | EPA | CPCat |
| CEDI | FDA | United States Food and Drug Administration (FDA) |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| SCIL (9/2019) | USEPA | Safer Chemical Ingredients List |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - specialized bath products - bath salts | Danish Environmental Protection Agency | Danish EPA |
| children; Europe; Personal care - body hygiene - body wash | Danish Environmental Protection Agency | Danish EPA |
| Cleaning products and household care - laundry and fabric treatment - laundry detergent; Europe | Danish EPA | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
| Europe; Personal care - oral and dental care - teeth whitener | Danish Environmental Protection Agency | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 50 of 60 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| <=50 | mg/kg | ADI | oral | Human | ToxValDB_WHO_JECFA_ADI |
| 2S7830E561 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2S7830E561 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2S7830E561 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 2S7830E561 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 333AG72FWJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 333AG72FWJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 333AG72FWJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 333AG72FWJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 40UAA97IT9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 40UAA97IT9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 40UAA97IT9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 40UAA97IT9 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 68401960MK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 68401960MK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 68401960MK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 68401960MK | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6B46OH7T95 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6B46OH7T95 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6B46OH7T95 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 6B46OH7T95 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C67P1734QJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C67P1734QJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C67P1734QJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| C67P1734QJ | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E54VE15114 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E54VE15114 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E54VE15114 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| E54VE15114 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FZ989GH94E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FZ989GH94E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FZ989GH94E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| FZ989GH94E | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H7AGY1OJO8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H7AGY1OJO8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H7AGY1OJO8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| H7AGY1OJO8 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K0KQV10C35 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K0KQV10C35 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K0KQV10C35 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| K0KQV10C35 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RDH86HJV5Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RDH86HJV5Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RDH86HJV5Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| RDH86HJV5Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SZR7Z3Q2YH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SZR7Z3Q2YH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SZR7Z3Q2YH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| SZR7Z3Q2YH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| U725QWY32X | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 50 of 60 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
film-former
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
crospovidone
ChEMBL Phase
Not listed
Adverse Events
89
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
E1201 — ADI: 0-50 mg/kg bw mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Polyvinylpyrrolidone?
Polyvinylpyrrolidone appears on 16 regulatory/inventory lists including IFRA Transparency, Canada; consumer_product; Substances in Products - Canada (4/2014), inert_ingredient; non_food_use; Pesticides, and 13 more. Source: EPA CPDat.
Is Polyvinylpyrrolidone a carcinogen according to IARC?
Polyvinylpyrrolidone is classified by IARC as Group 3 — not classifiable as to its carcinogenicity to humans (evaluated 1998). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Polyvinylpyrrolidone used in cosmetics?
Yes, Polyvinylpyrrolidone is also indexed as a cosmetic ingredient under the name PVP. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Polyvinylpyrrolidone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Polyvinylpyrrolidone used outside industrial chemicals?
Polyvinylpyrrolidone also appears in cosmetics, pharmaceutical, food safety, cannabis databases.