Is Prenol safe in cosmetics?
Prenol has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Prenol
Also known as: 3-Methylbut-2-en-1-ol, 4-01-00-02129, BRN 1633479, EINECS 209-141-4, FEMA No. 3647 (+8 more)
INCI: PRENOL
Prenol (CAS 556-82-1) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient; 3-methyl-2-buten-1-ol used as aroma chemical. NOAEL 82.1 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted; GHS signal word WARNING. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 556-82-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Prenol is classified GHS Danger (H226, H302, H314, H315, H318, H319, H371, H402) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance ingredient; 3-methyl-2-buten-1-ol used as aroma chemical
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3-methylbut-2-en-1-ol
InChIKey
ASUAYTHWZCLXAN-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No specific CIR review; IFRA-regulated as a fragrance ingredient
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Prenol.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Signal Word
WARNING
Pictograms
FlamFlameExcl markWarn
Hazard Statements
Flammable liquid and vapour Harmful if swallowed Causes skin irritation Causes serious eye irritation Harmful to aquatic life
Short-term Exposure Effects
The substance is severely irritating to the skin and eyes.
Routes of Exposure
The substance can be absorbed into the body by ingestion and by inhalation of its vapour.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Prenol across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6750 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
ICSC Safety Card
1760
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Regulatory (5)
JECFA Number
1200
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3,3-DIMETHYLALLYL ALCOHOL | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/75 | FAS 52-JECFA 61/289
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-METHYL-2-BUTEN-1-OL | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/75 | FAS 52-JECFA 61/289
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3-METHYLCROTYL ALCOHOL | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/75 | FAS 52-JECFA 61/289
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
PRENYL ALCOHOL | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/75 | FAS 52-JECFA 61/289
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Prenol.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
3-Methylbut-2-en-1-ol
4-01-00-02129
BRN 1633479
EINECS 209-141-4
FEMA No. 3647
UNII-55MY0HM445
2-Butenol, 3-methyl
Butenol methyl
Dimethylallyl alcohol
FEMA 3647
Isopentenol
Isopentenyl alcohol
Methyl-3-but-2-en-1-ol
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3184952
Frequently Asked Questions
Is Prenol allowed in the EU?
Prenol EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Prenol do in cosmetics?
Prenol functions as: Fragrance ingredient; 3-methyl-2-buten-1-ol used as aroma chemical. It is classified as a cosmetic ingredient in our database. CAS number: 556-82-1.
Is Prenol classified as hazardous under GHS?
Prenol carries a GHS signal word of "WARNING". Hazard statements: Flammable liquid and vapour Harmful if swallowed Causes skin irritation Causes serious eye irritation Harmful to aquatic life. This classification is based on the ILO/WHO International Chemical Safety Card and ECHA C&L inventory data. Note: GHS classification applies to the pure substance — at cosmetic use concentrations, hazard thresholds may not be met.
Is Prenol used outside cosmetics?
Prenol also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Prenol have different safety status in cosmetics vs industrial chemicals?
Prenol is classified GHS Danger (H226, H302, H314, H315, H318, H319, H371, H402) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Prenol compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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