Is Methyl Isovalerate safe in cosmetics?
Methyl Isovalerate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Methyl Isovalerate
Also known as: 4-02-00-00897, BRN 1699922, EINECS 209-117-3, FEMA No. 2753, Methyl isopentanoate (+8 more)
INCI: METHYL ISOVALERATE (METHYL 3-METHYLBUTANOATE)
Methyl Isovalerate (CAS 556-24-1) is a cosmetic cosmetic ingredient functioning as Fragrance, flavoring agent. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 556-24-1 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance, flavoring agent
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
methyl 3-methylbutanoate
InChIKey
OQAGVSWESNCJJT-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Allowed; FEMA GRAS as a flavoring substance
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methyl Isovalerate.
Calculate MoS for your specific formulation with the MoS Calculator.
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
195
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
METHYL ISOVALERATE | 1997 | No safety concern at current levels of intake when used as a flavouring agent | TRS 884-JECFA 49/52 | FAS 40-JECFA 49/267
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Methyl Isovalerate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
4-02-00-00897
BRN 1699922
EINECS 209-117-3
FEMA No. 2753
Methyl isopentanoate
Methyl isovalerianate
Methyl 3-methylbutanoate
Methyl 3-methylbutyrate
UNII-QPS4788198
3-Methylbutanoic acid methyl ester
FEMA 2753
Isovaleric acid, methyl ester
Methyl isovalerate [UN2400] [Flammable liquid]
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Methyl Isovalerate allowed in the EU?
Methyl Isovalerate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Isovalerate do in cosmetics?
Methyl Isovalerate functions as: Fragrance, flavoring agent. It is classified as a cosmetic ingredient in our database. CAS number: 556-24-1.
Is Methyl Isovalerate used outside cosmetics?
Methyl Isovalerate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Methyl Isovalerate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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