What is the NOAEL for 3-Methyl-2-buten-1-ol?
3-Methyl-2-buten-1-ol has 8 NOAEL studies in the database. The lowest reported value is 55MY0HM445 UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
3-Methyl-2-buten-1-ol
Also known as: 3-Methylbut-2-en-1-ol, 4-01-00-02129, BRN 1633479, EINECS 209-141-4, FEMA No. 3647 (+9 more)
CAS 556-82-1
3-Methyl-2-buten-1-ol (CAS 556-82-1) is a chemical substance. Key regulatory status: REACH registered, 4 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH, ILO ICSC.
Cross-Vertical Regulatory Divergence
3-Methyl-2-buten-1-ol is classified GHS Danger (H226, H302, H314, H315, H318, H319, H371, H402) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
8
SOURCE
chemical inventory jurisdictions
Regulatory lists
4
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eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
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DSSTox identifiers
20 fields
Name
3-Methyl-2-buten-1-ol
CAS Number
556-82-1
DTXSID
DTXSID2027206
Molecular Formula
C5H10O
InChI Key
ASUAYTHWZCLXAN-UHFFFAOYSA-N
Monoisotopic Mass
86.073165
Synonyms
3-Methylbut-2-en-1-ol4-01-00-02129BRN 1633479EINECS 209-141-4FEMA No. 3647UNII-55MY0HM4452-Butenol, 3-methylButenol methylDimethylallyl alcoholFEMA 3647IsopentenolIsopentenyl alcohol
ICSC Chemical Safety
International Chemical Safety Card hazard and exposure summary.
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ILO/WHO International Chemical Safety Cards
1 records
| Field | Value |
|---|---|
| GHS Signal Word | WARNING |
| GHS Hazard Statements | Flammable liquid and vapour Harmful if swallowed Causes skin irritation Causes serious eye irritation Harmful to aquatic life |
| Short-term Effects | The substance is severely irritating to the skin and eyes. |
| Routes of Exposure | The substance can be absorbed into the body by ingestion and by inhalation of its vapour. |
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
4 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 8 of 8 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 55MY0HM445 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 55MY0HM445 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 55MY0HM445 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 55MY0HM445 | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 6750 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =152 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_HESS |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 8 of 8 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 3-methylbut-2-en-1-ol | 209-141-4 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
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AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CHEMBL3184952
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
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EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 3-Methyl-2-buten-1-ol?
3-Methyl-2-buten-1-ol appears on 4 regulatory/inventory lists including IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), consumer_product, and 1 more. Source: EPA CPDat.
Is 3-Methyl-2-buten-1-ol used in cosmetics?
Yes, 3-Methyl-2-buten-1-ol is also indexed as a cosmetic ingredient under the name Prenol. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 3-Methyl-2-buten-1-ol come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, ILO/WHO ICSC, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Does 3-Methyl-2-buten-1-ol have different safety status in cosmetics vs industrial chemicals?
3-Methyl-2-buten-1-ol is classified GHS Danger (H226, H302, H314, H315, H318, H319, H371, H402) in the chemicals database but is allowed in EU cosmetics.
Is 3-Methyl-2-buten-1-ol used outside industrial chemicals?
3-Methyl-2-buten-1-ol also appears in cosmetics, pharmaceutical, food safety, cannabis databases.