Is Pregnenolone Acetate safe in cosmetics?
Pregnenolone Acetate has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted.
Poor
Cosmetic Ingredient
Pregnenolone Acetate
Also known as: EINECS 217-212-6, UNII-0G0WWV404B, 3beta-Hydroxypregn-5-en-20-one acetate
INCI: PREGNENOLONE ACETATE
Pregnenolone Acetate (CAS 1778-02-5) is a cosmetic cosmetic ingredient functioning as Skin conditioning agent with anti-aging and hydration properties. EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 1778-02-5 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Pregnenolone Acetate is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H332, H351, H361, H362).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Skin conditioning agent with anti-aging and hydration properties
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
[(3S,8S,9S,10R,13S,14S,17S)-17-acetyl-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate
InChIKey
CRRKVZVYZQXICQ-RJJCNJEVSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
Not specifically prohibited but hormonal claims would classify product as a drug. Cosmetic use at low concentrations exists historically.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Pregnenolone Acetate.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
JPKR Japan/Korea Cosmetics
Japan (Prohibited): ; Category: General
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| JP | banned | - | All cosmetics |
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Pregnenolone Acetate.
Known Synonyms
EINECS 217-212-6
UNII-0G0WWV404B
3beta-Hydroxypregn-5-en-20-one acetate
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL1892286
Frequently Asked Questions
Is Pregnenolone Acetate allowed in the EU?
Pregnenolone Acetate EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Pregnenolone Acetate do in cosmetics?
Pregnenolone Acetate functions as: Skin conditioning agent with anti-aging and hydration properties. It is classified as a cosmetic ingredient in our database. CAS number: 1778-02-5.
Is Pregnenolone Acetate used outside cosmetics?
Pregnenolone Acetate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Pregnenolone Acetate have different safety status in cosmetics vs industrial chemicals?
Pregnenolone Acetate is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H332, H351, H361, H362).
Compliance Tools
Check Pregnenolone Acetate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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