What is the NOAEL for Dehydroepiandrosterone?
Dehydroepiandrosterone has 18 NOAEL studies in the database. The lowest reported value is 1.3925774436921 uM. Source: NTP_ICE_endocrine.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Dehydroepiandrosterone
Also known as: DHEA, 5,6-Didehydroisoandrosterone, Prasterone, 4-08-00-00994, BRN 2058110 (+14 more)
CAS 53-43-0
Dehydroepiandrosterone (CAS 53-43-0) is a chemical substance. Key regulatory status: REACH registered, 9 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
Dehydroepiandrosterone is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H315, H319, H332, H335, H351, H360).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
18
SOURCE
chemical inventory jurisdictions
Regulatory lists
9
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
25 fields
Name
Dehydroepiandrosterone
CAS Number
53-43-0
DTXSID
DTXSID4020379
Molecular Formula
C19H28O2
InChI Key
FMGSKLZLMKYGDP-USOAJAOKSA-N
Monoisotopic Mass
288.20893
Synonyms
DHEA5,6-DidehydroisoandrosteronePrasterone4-08-00-00994BRN 2058110Caswell No. 051F5,6-DehydroisoandrostoroneEINECS 200-175-5EPA Pesticide Chemical Code 126510Epiandrosterone, 5-dehydro-UNII-459AG36T1BGynodian
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
3 records
Softener and conditionerPharmaceutical
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
9 records
| List | Keyword | Source |
|---|---|---|
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| Canada; consumer_product; Substances in Products - Canada (4/2014) | Government of Canada | CPCat |
| pharmaceutical | US International Trade Commission | CPCat |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| pharmaceutical; prohibited | World Anti-Doping Agency | World Anti-Doping Agency |
| pharmaceutical; prohibited | World Anti-Doping Agency | World Anti-Doping Agency |
| pharmaceutical | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 18 of 18 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2.35211202055101 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 15.791608942219 | uM | AC50 | - | - | NTP_ICE_endocrine |
| 1.3925774436921 | uM | ACC | - | - | NTP_ICE_endocrine |
| 14.5084123621742 | uM | ACC | - | - | NTP_ICE_endocrine |
| 459AG36T1B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 459AG36T1B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 459AG36T1B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 459AG36T1B | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| >10000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =0.6 | mg/100 g BW | LEL | injection | Rat | ToxValDB_Uterotrophic_Hershberger_DB |
| =1 | mg/day | LEL | oral | Rat | ToxValDB_Uterotrophic_Hershberger_DB |
| =6 | mg | LEL | injection | Rat | ToxValDB_Uterotrophic_Hershberger_DB |
| =30 | mg/kg bw/day | LEL | injection | Rat | ToxValDB_Uterotrophic_Hershberger_DB |
| =2000 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_Uterotrophic_Hershberger_DB |
| - | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.365 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| 0.443 | unitless | Model Score | - | - | NTP_ICE_endocrine |
| =1000 | mg/kg bw/day | NOEL | oral | Rat | ToxValDB_ECOTOX |
Showing 18 of 18 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Prasterone | 200-175-5 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Skin Conditioning
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PRASTERONE
ChEMBL Phase
4
Adverse Events
832
Bioactivity
12
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
1 food-safety record found.
View full food safety profile →Frequently Asked Questions
What regulatory lists include Dehydroepiandrosterone?
Dehydroepiandrosterone appears on 4 regulatory/inventory lists including Canada; consumer_product; Substances in Products - Canada (4/2014), pharmaceutical, Canada; pharmaceutical, and 1 more. Source: EPA CPDat.
Is Dehydroepiandrosterone used in cosmetics?
Yes, Dehydroepiandrosterone is also indexed as a cosmetic ingredient under the name Prasterone (DHEA). View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Dehydroepiandrosterone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS. All data traces to primary regulatory sources and is updated from official government databases.
Does Dehydroepiandrosterone have different safety status in cosmetics vs industrial chemicals?
Dehydroepiandrosterone is prohibited in EU cosmetics but has active industrial GHS classifications (H302, H312, H315, H319, H332, H335, H351, H360).
Is Dehydroepiandrosterone used outside industrial chemicals?
Dehydroepiandrosterone also appears in cosmetics, pharmaceutical, food safety databases.