Is Piperonylic Acid safe in cosmetics?
Piperonylic Acid has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Piperonylic Acid
Also known as: 5-Benzodioxolecarboxylic acid, Benzoic acid, 3,4-(methylenedioxy)-, 3,4-Dioxymethylenebenzoic acid, EINECS 202-342-8, Heliotropic acid (+4 more)
INCI: PIPERONYLIC ACID
Piperonylic Acid (CAS 94-53-1) is a cosmetic cosmetic ingredient functioning as Fragrance, skin conditioning. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 94-53-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Piperonylic Acid is classified GHS Danger (H302, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance, skin conditioning
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
1,3-benzodioxole-5-carboxylic acid
InChIKey
VDVJGIYXDVPQLP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Not specifically restricted by FDA
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Piperonylic Acid.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Humectant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Piperonylic Acid.
Regulatory Flags
fragrance-component
Known Synonyms
5-Benzodioxolecarboxylic acid
Benzoic acid, 3,4-(methylenedioxy)-
3,4-Dioxymethylenebenzoic acid
EINECS 202-342-8
Heliotropic acid
3,4-Methylene dioxybenzoic acid
NSC 10072
Protocatechuic acid methylene ether
UNII-QX3V1NO0KH
Chemical Function
Humectant
Softener and conditioner
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
PIPERONYLIC ACID
ChEMBL ID
CHEMBL573781
Frequently Asked Questions
Is Piperonylic Acid allowed in the EU?
Piperonylic Acid EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Piperonylic Acid do in cosmetics?
Piperonylic Acid functions as: Fragrance, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 94-53-1.
Is Piperonylic Acid used outside cosmetics?
Piperonylic Acid also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Piperonylic Acid have different safety status in cosmetics vs industrial chemicals?
Piperonylic Acid is classified GHS Danger (H302, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Piperonylic Acid compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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