What is the NOAEL for 1,3-Benzodioxole-5-carboxylic acid?
1,3-Benzodioxole-5-carboxylic acid has 4 NOAEL studies in the database. The lowest reported value is QX3V1NO0KH UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
1,3-Benzodioxole-5-carboxylic acid
Also known as: 5-Benzodioxolecarboxylic acid, Benzoic acid, 3,4-(methylenedioxy)-, 3,4-Dioxymethylenebenzoic acid, EINECS 202-342-8, Heliotropic acid (+4 more)
CAS 94-53-1
1,3-Benzodioxole-5-carboxylic acid (CAS 94-53-1) is a chemical substance. Key regulatory status: REACH registered, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
Cross-Vertical Regulatory Divergence
1,3-Benzodioxole-5-carboxylic acid is classified GHS Danger (H302, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
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noael studies public
NOAEL studies
4
SOURCE
chemical inventory jurisdictions
Regulatory lists
0
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
1,3-Benzodioxole-5-carboxylic acid
CAS Number
94-53-1
DTXSID
DTXSID6059104
Molecular Formula
C8H6O4
InChI Key
VDVJGIYXDVPQLP-UHFFFAOYSA-N
Monoisotopic Mass
166.026609
Synonyms
5-Benzodioxolecarboxylic acidBenzoic acid, 3,4-(methylenedioxy)-3,4-Dioxymethylenebenzoic acidEINECS 202-342-8Heliotropic acid3,4-Methylene dioxybenzoic acidNSC 10072Protocatechuic acid methylene etherUNII-QX3V1NO0KH
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
2 records
HumectantSoftener and conditioner
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 4 of 4 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| QX3V1NO0KH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QX3V1NO0KH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QX3V1NO0KH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| QX3V1NO0KH | UNII | FDA UNII substance identifier | - | - | openFDA substances |
Showing 4 of 4 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Piperonylic acid | 202-342-8 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
PIPERONYLIC ACID
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
3
Frequently Asked Questions
Is 1,3-Benzodioxole-5-carboxylic acid used in cosmetics?
Yes, 1,3-Benzodioxole-5-carboxylic acid is also indexed as a cosmetic ingredient under the name Piperonylic Acid. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 1,3-Benzodioxole-5-carboxylic acid come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed. All data traces to primary regulatory sources and is updated from official government databases.
Does 1,3-Benzodioxole-5-carboxylic acid have different safety status in cosmetics vs industrial chemicals?
1,3-Benzodioxole-5-carboxylic acid is classified GHS Danger (H302, H315, H318, H319, H335) in the chemicals database but is allowed in EU cosmetics.
Is 1,3-Benzodioxole-5-carboxylic acid used outside industrial chemicals?
1,3-Benzodioxole-5-carboxylic acid also appears in cosmetics, pharmaceutical databases.