Is Benzoyl Peroxide Regulatory & safe in cosmetics?
Benzoyl Peroxide Regulatory & has a safety rating of "GOOD" in our database. EU status: restricted. US status: restricted.
Benzoyl Peroxide Regulatory &
Also known as: Akneroxid 5, Asidopan, Aztec BPO, Benoxyl (5&10) Lotion, Benzoic acid, peroxide (+15 more)
INCI: BENZOYL PEROXIDE
Benzoyl Peroxide Regulatory & (CAS 94-36-0) is a cosmetic cosmetic ingredient functioning as Insufficient Data. NOAEL 500 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 94-36-0 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Benzoyl Peroxide Regulatory & is classified GHS Danger (H241, H317, H319, H400, H410, H335, H316) in the chemicals database but is restricted in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Insufficient Data
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
benzoyl benzenecarboperoxoate
InChIKey
OMPJBNCRMGITSC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
restricted
US Notes
OTC drug classification; no specific concentration restrictions
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Benzoyl Peroxide Regulatory &.
Calculate MoS for your specific formulation with the MoS Calculator.
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization.
Routes of Exposure
The substance can be absorbed into the body by inhalation of its aerosol.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Benzoyl Peroxide Regulatory & across SCCS product categories, with measured dermal absorption where available.
Dermal Penetration Profile
Skin absorption and penetration characteristics of Benzoyl Peroxide Regulatory &, relevant to systemic exposure and MoS calculations.
Absorption %
10-20%
Penetration Level
epidermis
Penetration Depth
epidermis
Molecular Weight
242.2 Da
Log P
1.67
Systemic Absorption
minimal
Topical Bioavailability
6-16%
Safety Margin Factor
moderate
Vehicle Dependent
Yes — absorption varies by formulation
Source: SCCS Opinion, CIR
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
36, Sup 7, 71
Evaluation Year
1998
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
ExplosiveFlammableHarmful / IrritantEnvironmental Hazard
Hazard Class and Category
Org. Perox. B; Eye Irrit. 2; Skin Sens. 1; Aquatic Acute 1; Aquatic Chronic 1
Hazard Statements
- H241
- H319 Causes serious eye irritation
- H317 May cause an allergic skin reaction
- H400 Very toxic to aquatic life
- H410 Very toxic to aquatic life with long lasting effects
Specific Concentration Limits / M-factors
M = 10; M = 10
Inserted via ATP: ATP22
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
100%
DPRA Lys %
81.3%
KeratinoSens IC50
567.615 µM
hCLAT CV75
41 µg/mL
LLNA EC3
0.043%
NESIL
14177 µg/cm²
LLNA: Strong (1A)
GHS: 1A
Human: positive
Source: LLNA: Kimber et al. (1998); DPRA: Gerberick et al. 2007 [DOI:10.1093/toxsci/kfm064]; KS: Natsch et al. 2013 [DOI:10.1002/jat.2868] | Emter et al. 2010 [DOI:10.1016/j.taap.2010.03.009]; hCLAT: Ashikaga et al. 2010 [DOI:10.1177/026119291003800403]; HPPT: [791] Poole RL et al. (1970): https://jamanetwork.com/journals/jamadermatology/article-abstract/531
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | 14177.16 | - | - |
| OECD_DA_Human | - | 0 | - | - | 1B (Weak sensitizer) |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1,000 - 10,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
SA Saudi SFDA (III - Restricted)
Product type: Artificial nail systems. Max: 0.7% (after mixing for use).
BRIN Brazil/India Cosmetics
Brazil: Prohibited
India: Restricted · max 0.7% (after mixing for use)
Additional Jurisdictional Restrictions (6)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CN | banned | - | - |
| AU | therapeutic_good | 5.0 | acne treatment |
| CA | restricted | 10% | Nail products (catalyst); hair dyes only |
| CA | drug_classification | - | - |
| ASEAN | restricted | 0.7% after mixing | Artificial nail systems |
| KR | prohibited | - | - |
Additional Ingredient Properties
9 property records from structured ingredient metadata.
acne
{"cas_number": "94-36-0", "anti_acne_mechanism": "antibacterial/keratolytic/comedolytic", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory/non_inflammatory", "p_acnes_mic_ug_per_ml": "50-200", "sebum_reduction_pct_clinical": "10-15", "keratolytic_strength": "moderate", "exfoliation_mechanism": "chemical", "optimal_ph_for_efficacy": "5.0-7.0", "peel_depth": "superficial", "p…
baby_pediatric
{"cas_number": "94-36-0", "ingredient_class": "other", "pediatric_safety_rating": "avoid", "minimum_age_months": "12", "neonatal_safe": "no", "premature_infant_safe": "no", "skin_barrier_maturity_consideration": "AVOID: Acne treatment unsuitable for babies; irritating, oxidizing", "transepidermal_absorption_risk_pediatric": "high", "systemic_exposure_concern_pediatric": "moderate", "dose_per_kg_bo…
concentration
{"min_concentration_pct": "2.5", "max_concentration_pct": "10.0", "typical_concentration_pct": "5.0", "product_type": "Leave-on Treatment", "function_at_concentration": "Anti-acne", "source": "FDA OTC Monograph"}
dermal_absorption
{"molecular_weight_da": "242.2", "log_p_value": "1.67", "skin_penetration_level": "epidermis", "penetration_depth": "epidermis", "absorption_pct": "10-20", "systemic_absorption": "minimal", "penetration_enhancer": "yes", "occlusion_effect": "no", "vehicle_dependent": "yes", "skin_barrier_effect": "weakens", "bioavailability_topical_pct": "6-16", "safety_margin_factor": "moderate", "source": "SCCS …
interactions
{"ingredient_2": "Metal containers", "interaction_type": "destabilizing", "severity": "avoid", "effect": "BP can react with metals, degradation", "recommendation": "Use plastic or glass containers only", "data_source": "Formulation science literature, dermatological research, cosmetic chemistry best practices", "last_updated": "2026-03-05"}
microbiome_impact
{"microbiome_effect": "negative", "prebiotic": "no", "probiotic_compatible": "no", "antimicrobial_spectrum": "broad", "preservative_effect_on_microbiome": "Potent oxidizer; severe microbiome disruption; broad antimicrobial", "skin_flora_disruption": "severe", "gut_microbiome_risk": "low", "microbiome_recovery_time": "14-21 days", "selective_antimicrobial": "no", "pathogen_inhibition": "C. acnes, S…
pediatric_safety
{"safe_for_newborn_0_6m": "avoid", "safe_for_infant_6_12m": "avoid", "safe_for_toddler_1_3y": "caution", "safe_for_child_3_12y": "caution", "safe_for_teen_12_18y": "yes", "pediatric_max_concentration_pct": "0.0", "adult_max_concentration_pct": "2.5", "pediatric_dermal_absorption_factor": "high", "immature_skin_barrier_risk": "high", "oral_ingestion_risk": "low", "eye_irritation_risk": "high", "dia…
pregnancy_detail
{"pregnancy_safe": "yes", "breastfeeding_safe": "yes", "risk_category": "FDA-C", "reason": "Safe topically in limited amounts; ~5% absorbed, rapidly metabolized", "alternative_ingredient": "N/A (limit to ≤5%)", "source": "ACOG; PMC3114665"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (4)
Carcinogen Classification
Benzoyl peroxide | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 36: (1985) Allyl Compounds, Aldehydes, Epoxides and Peroxides | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 71: (1999) Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide
Source: International Agency for Research on Cancer (IARC)
Evidence for Carcinogenicity
Evaluation: There is inadequate evidence in humans for the carcinogenicity of benzoyl peroxide. There is limited evidence in experimental animals for the carcinogenicity of benzoyl peroxide. Overall evaluation: Benzoyl peroxide is not classifiable as to its carcinogenicity to humans (Group 3). | A4: Not classifiable as a human carcinogen.
Source: Hazardous Substances Data Bank (HSDB)
ICSC Safety Card
0225
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Skin Eye Respiratory Irritation
An allergen and eye irritant. | Benzoyl peroxide dust irritates the eyes of albino rabbits ... . | Potential symptoms of overexposure are irritation of skin, eyes and mucous membranes ... . | In an investigation made in a plant located in New York state where benzoyl peroxide formulations were being processed ... no objectionable subjective symptoms /were experienced/ when exposed to dust concentr
Source: Hazardous Substances Data Bank (HSDB)
Regulatory (1)
JECFA Evaluation
BENZOYL PEROXIDE | 2004 | NOT SPECIFIED | Treatment of whey with benzoyl peroxide at a maximum concentration of 100 mg/kg does not pose a safety concern. | TRS 928-JECFA 63/13 | FAS 54-JECFA 63/17
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Adhesion/cohesion promoter
Catalyst
Chemical reaction regulator
Dye
Food preservative
Hardener
Oxidizing agent
Pharmaceutical
Regulatory List Membership (2)
FDA Substances Added to Food (EAFUS)
EU CosIng Cosmetics Ingredient Database
Expert Verdict
Expert safety assessment and concern-level summary for Benzoyl Peroxide Regulatory &.
Regulatory Flags
EU Restricted
fda_food_additive
eu_cosing_listed
Known Synonyms
Akneroxid 5
Asidopan
Aztec BPO
Benoxyl (5&10) Lotion
Benzoic acid, peroxide
Benzol peroxide
Cadat BPO
Cadox BS
Clearasil Antibacterial Acne Lotion
Clearasil BP Acne Treatment Cream
Duresthin 5
EINECS 202-327-6
Epi Clear Antiseptic Lotion
Incidol
Luperox FL
Mytolac
Nayper B and BO
Nayper bo
Norox bzp-C-35
Norox bzp-250
Chemical Function
Oxidizing agent
Pharmaceutical
Adhesion/cohesion promoter
Catalyst
Regulatory Lists
active_ingredient; Australia
inert_ingredient; non_food_use; Pesticides
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Canada; pharmaceutical
consumer_product; Europe
drinking_water; Europe; manufacturing; plastic_additive
active_ingredient; Europe; Pesticides
Europe; Personal care; restricted
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
BENZOYL PEROXIDE
ChEMBL ID
CHEMBL1200370
Max Phase
4
Adverse Event Associations
198
Frequently Asked Questions
Is Benzoyl Peroxide Regulatory & allowed in the EU?
Benzoyl Peroxide Regulatory & EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Benzoyl Peroxide Regulatory & do in cosmetics?
Benzoyl Peroxide Regulatory & functions as: Insufficient Data. It is classified as a cosmetic ingredient in our database. CAS number: 94-36-0.
Is Benzoyl Peroxide Regulatory & used outside cosmetics?
Benzoyl Peroxide Regulatory & also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Benzoyl Peroxide Regulatory & have different safety status in cosmetics vs industrial chemicals?
Benzoyl Peroxide Regulatory & is classified GHS Danger (H241, H317, H319, H400, H410, H335, H316) in the chemicals database but is restricted in EU cosmetics.
Compliance Tools
Check Benzoyl Peroxide Regulatory & compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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