Is Phenethyl Methacrylate safe in cosmetics?
Phenethyl Methacrylate has a safety rating of "MODERATE" in our database. EU status: permitted. US status: restricted.
Moderate
Cosmetic Ingredient
Phenethyl Methacrylate
Also known as: 2-Propenoic acid, 2-methyl-, 2-phenylethyl ester, 3-06-00-01710, BRN 2329237, EINECS 222-969-0, beta-Phenylethyl methacrylate (+2 more)
INCI: PHENETHYL METHACRYLATE
Phenethyl Methacrylate (CAS 3683-12-3) is a cosmetic cosmetic ingredient functioning as Film forming / Fragrance (context-dependent). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 3683-12-3 →
Auto-generated CPSR Part A draft with source citations
Function
Film forming / Fragrance (context-dependent)
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
2-phenylethyl 2-methylprop-2-enoate
InChIKey
ILZXXGLGJZQLTR-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
restricted
US Notes
Not specifically restricted by FDA for cosmetic use; methacrylate monomers flagged in professional nail product context
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Phenethyl Methacrylate.
Calculate MoS for your specific formulation with the MoS Calculator.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
775 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [409] Kligman AM (1978): Report to RIFM, 24 October, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 4050 | - | - |
| HRIPT | - | 0 | 775 | - | - |
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Fragrance
Expert Verdict
Expert safety assessment and concern-level summary for Phenethyl Methacrylate.
Regulatory Flags
potential-allergen
fragrance-component
Known Synonyms
2-Propenoic acid, 2-methyl-, 2-phenylethyl ester
3-06-00-01710
BRN 2329237
EINECS 222-969-0
beta-Phenylethyl methacrylate
beta-Phenylethyl 2-methylpropenate
Phenylethyl 2-methyl-2-propenoate
Chemical Function
Fragrance
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Phenethyl Methacrylate allowed in the EU?
Phenethyl Methacrylate EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Phenethyl Methacrylate do in cosmetics?
Phenethyl Methacrylate functions as: Film forming / Fragrance (context-dependent). It is classified as a cosmetic ingredient in our database. CAS number: 3683-12-3.
Is Phenethyl Methacrylate used outside cosmetics?
Phenethyl Methacrylate also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Phenethyl Methacrylate compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
Related Ingredients
2,6-Dimethyl-7-octen-2-ol (Dihydromyrcenol)
Excellent
Same category
Fragrance (perfuming), masking
2-Ethoxy-2,6,6-Trimethyl-9-Methylenebicyclo[3.3.1]Nonane (Boisiris™)
Excellent
Same category
Fragrance (rich woody, orris/iris roo...
3,6-Dimethyl-3-Octyl Acetate
Excellent
Same category
Fragrance / Perfuming agent with flor...
3-Methyl-5-(2,2,3-Trimethyl-3-Cyclopentenyl)Pent-4-En-2-Ol (Sandalore)
Excellent
Same category
Perfuming / Fragrance (sandalwood note)
4-Tert-Butylcyclohexyl Acetate
Excellent
Same category
Fragrance
Acetoin
Excellent
Same category
Skin conditioning, fragrance
(20S)-Protopanaxadiol
Moderate
Similar safety
(Cnidium Officinale/Coptis Chinensis/Glycyrrhiza Uralensis) Root Extract
Moderate
Similar safety
Skin conditioning
(Cryptomeria Japonica/Chamaecyparis Obtusa) Stem Ferment Extract
Moderate
Similar safety
Antimicrobial, antioxidant, humectant
(Eclipta Prostrata/Houttuynia Cordata) Leaf Extract
Moderate
Similar safety
Skin conditioning
(Lepidium Meyenii/Sarcodon Aspratus) Root Water
Moderate
Similar safety
Skin conditioning
(Licorice/Reynoutria Japonica) Root/Stem Extract
Moderate
Similar safety
Skin conditioning, antioxidant
PHELLODENDRON AMURENSE BARK/GARDENIA FLORIDA FRUIT/(COPTIS JAPONICA/DIOSCOREA JAPONICA/LICORICE/PAEONIA SUFFRUTICOSA/PUERARIA LOBATA/REHMANNIA CHINENSIS/SCUTELLARIA BAICALENSIS/SOPHORA FLAVESCENS ROOT) WATER
Good
Browse nearby
Skin Conditioning - Miscellaneous
PHELLODENDRON AMURENSE BARK/HONEYSUCKLE FLOWER/(ECLIPTA PROSTRATA/MENTHA ARVENSIS LEAF)/SCUTELLARIA BAICALENSIS ROOT EXTRACT
Good
Browse nearby
Skin Conditioning
PHMB Cosmetic
Moderate
Browse nearby
Preservative
Is Phenethyl Methacrylate in Your Products?
Scan any product label with Piro — our free ingredient scanner. Point your camera at the ingredients list and get instant safety scores for every ingredient.
Try Piro Free →Analyze Your Full Ingredient List
Paste any INCI list into the Decoder for instant safety analysis, or calculate the Margin of Safety for Phenethyl Methacrylate in your formulation.