Is Perfluorohexylethyl Triethoxysilane safe in cosmetics?
Perfluorohexylethyl Triethoxysilane has a safety rating of "POOR" in our database. EU status: prohibited. US status: restricted.
Poor
Cosmetic Ingredient
Perfluorohexylethyl Triethoxysilane
Also known as: Silane, triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-, Triethoxy(1H,1H,2H,2H-perfluorooctyl)silane, Triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane, EINECS 257-473-3, UNII-814P46684U (+1 more)
INCI: PERFLUOROHEXYLETHYL TRIETHOXYSILANE
Perfluorohexylethyl Triethoxysilane (CAS 51851-37-7) is a cosmetic cosmetic ingredient functioning as Binder, skin conditioning. NOAEL 50 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: prohibited. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 51851-37-7 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Perfluorohexylethyl Triethoxysilane is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335).
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Binder, skin conditioning
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane
InChIKey
AVYKQOAMZCAHRG-UHFFFAOYSA-N
Regulatory Status
EU EU Status
prohibited
US US Status
restricted
US Notes
FDA flagged as having a potential safety concern in body lotion at the highest reported concentration (MoCRA PFAS report, Dec 2025)
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Perfluorohexylethyl Triethoxysilane.
Calculate MoS for your specific formulation with the MoS Calculator.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Perfluorohexylethyl Triethoxysilane across SCCS product categories, with measured dermal absorption where available.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Adhesion/cohesion promoter
Binder
Wetting agent (non-aqueous)
Expert Verdict
Expert safety assessment and concern-level summary for Perfluorohexylethyl Triethoxysilane.
Known Synonyms
Silane, triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-
Triethoxy(1H,1H,2H,2H-perfluorooctyl)silane
Triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane
EINECS 257-473-3
UNII-814P46684U
L-89-0099
Chemical Function
Binder
Adhesion/cohesion promoter
Wetting agent (non-aqueous)
Regulatory Lists
Europe; Personal care - make-up and related
Europe; Personal care - make-up and related
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Perfluorohexylethyl Triethoxysilane allowed in the EU?
Perfluorohexylethyl Triethoxysilane EU regulatory status: prohibited. This is based on EU Regulation 1223/2009 and its amendments.
What does Perfluorohexylethyl Triethoxysilane do in cosmetics?
Perfluorohexylethyl Triethoxysilane functions as: Binder, skin conditioning. It is classified as a cosmetic ingredient in our database. CAS number: 51851-37-7.
Is Perfluorohexylethyl Triethoxysilane used outside cosmetics?
Perfluorohexylethyl Triethoxysilane also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Perfluorohexylethyl Triethoxysilane have different safety status in cosmetics vs industrial chemicals?
Perfluorohexylethyl Triethoxysilane is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335).
Compliance Tools
Check Perfluorohexylethyl Triethoxysilane compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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Chemical family
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