What is the NOAEL for Triethoxy((perfluorohexyl)ethyl)silane?
Triethoxy((perfluorohexyl)ethyl)silane has 12 NOAEL studies in the database. The lowest reported value is 1.17 mg/m3 via inhalation in Human. Source: ToxValDB_GESTIS_DNEL.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Triethoxy((perfluorohexyl)ethyl)silane
Also known as: Silane, triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-, Triethoxy(1H,1H,2H,2H-perfluorooctyl)silane, Triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane, EINECS 257-473-3, UNII-814P46684U (+1 more)
CAS 51851-37-7
Triethoxy((perfluorohexyl)ethyl)silane (CAS 51851-37-7) is a chemical substance. Key regulatory status: REACH registered, 2 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
View cosmetic safety profile for Perfluorohexylethyl Triethoxysilane →
Cross-Vertical Regulatory Divergence
Triethoxy((perfluorohexyl)ethyl)silane is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335).
SOURCE
Cross-vertical comparison
Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
SOURCE
noael studies public
NOAEL studies
12
SOURCE
chemical inventory jurisdictions
Regulatory lists
2
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
12 fields
Name
Triethoxy((perfluorohexyl)ethyl)silane
CAS Number
51851-37-7
DTXSID
DTXSID1074915
Molecular Formula
C14H19F13O3Si
InChI Key
AVYKQOAMZCAHRG-UHFFFAOYSA-N
Monoisotopic Mass
510.089587
Synonyms
Silane, triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)-Triethoxy(1H,1H,2H,2H-perfluorooctyl)silaneTriethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silaneEINECS 257-473-3UNII-814P46684UL-89-0099
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
6 records
BinderAdhesion/cohesion promoterWetting agent (non-aqueous)
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
2 records
| List | Keyword | Source |
|---|---|---|
| Europe; Personal care - make-up and related | Danish EPA | Danish EPA |
| Europe; Personal care - make-up and related | Danish EPA | Danish EPA |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 12 of 12 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| =1.17 | mg/m3 | DNEL systemic | inhalation | Human | ToxValDB_GESTIS_DNEL |
| 814P46684U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 814P46684U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 814P46684U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 814P46684U | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| =100 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =175 | mg/kg bw/day | LEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =100 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_PFAS_150_SEM_v2 |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =50 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_PFAS_150_SEM_v2 |
| =125 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_EPA_TSCA_8e |
| =125 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_PFAS_150_SEM_v2 |
Showing 12 of 12 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Triethoxy(3,3,4,4,5,5,6,6,7,7,8,8,8-tridecafluorooctyl)silane | 257-473-3 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
prohibited
Max
-
Category
Skin Conditioning
Frequently Asked Questions
What regulatory lists include Triethoxy((perfluorohexyl)ethyl)silane?
Triethoxy((perfluorohexyl)ethyl)silane appears on 1 regulatory/inventory list including Europe; Personal care - make-up and related. Source: EPA CPDat.
Is Triethoxy((perfluorohexyl)ethyl)silane used in cosmetics?
Yes, Triethoxy((perfluorohexyl)ethyl)silane is also indexed as a cosmetic ingredient under the name Perfluorohexylethyl Triethoxysilane. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Triethoxy((perfluorohexyl)ethyl)silane come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Does Triethoxy((perfluorohexyl)ethyl)silane have different safety status in cosmetics vs industrial chemicals?
Triethoxy((perfluorohexyl)ethyl)silane is prohibited in EU cosmetics but has active industrial GHS classifications (H315, H319, H335).
Is Triethoxy((perfluorohexyl)ethyl)silane used outside industrial chemicals?
Triethoxy((perfluorohexyl)ethyl)silane also appears in cosmetics databases.