Is Oligopeptide-34 safe in cosmetics?
Oligopeptide-34 has a safety rating of "MODERATE" in our database. EU status: permitted. US status: permitted.
Moderate
Cosmetic Ingredient
Oligopeptide-34
INCI: OLIGOPEPTIDE-34
Oligopeptide-34 (CAS 2227218-62-2) is a cosmetic cosmetic ingredient functioning as Skin conditioning, skin brightening (multi-target melanogenesis inhibitor:. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 2227218-62-2 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, skin brightening (multi-target melanogenesis inhibitor: tyrosinase, TRP-1, TRP-2, MITF downregulation)
Safety Rating
MODERATE
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA ingredient-specific restrictions. Not reviewed by CIR. Falls under general cosmetic framework and MoCRA registration requirements. No GRASE classification. Supplier toxicological dossier should be requested from Caregen or Spec-Chem to support safety substantiation.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Oligopeptide-34.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
1 property record from structured ingredient metadata.
anti_aging
{"anti_aging_claim": "brightening, dark-spot-reduction", "mechanism_of_action": "Signal peptide for fibroblast activation", "target_skin_layer": "dermis", "collagen_stimulation": "Moderate", "elastin_protection": "Moderate", "wrinkle_reduction_pct": "12-20", "clinical_study_duration_weeks": "8", "sample_size": "25", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD, In…
Expert Verdict
Expert safety assessment and concern-level summary for Oligopeptide-34.
Regulatory Flags
no-sccs-opinion
no-cir-review
no-mos-calculated
no-dermal-absorption-data
no-sensitization-data
data-gap-high
supplier-dossier-required
Frequently Asked Questions
Is Oligopeptide-34 allowed in the EU?
Oligopeptide-34 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Oligopeptide-34 do in cosmetics?
Oligopeptide-34 functions as: Skin conditioning, skin brightening (multi-target melanogenesis inhibitor: tyrosinase, TRP-1, TRP-2, MITF downregulation). It is classified as a cosmetic ingredient in our database. CAS number: 2227218-62-2.
Compliance Tools
Check Oligopeptide-34 compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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