Is Acetyl Tetrapeptide-15 safe in cosmetics?
Acetyl Tetrapeptide-15 has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Acetyl Tetrapeptide-15
INCI: ACETYL TETRAPEPTIDE-15
Acetyl Tetrapeptide-15 (CAS 928007-64-1) is a cosmetic cosmetic ingredient functioning as Skin conditioning, neurotransmitter-inhibiting (mu-opioid receptor agonist,. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 928007-64-1 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, neurotransmitter-inhibiting (mu-opioid receptor agonist, CGRP release inhibition for sensitive skin)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
(2S)-1-[(2S)-2-acetamido-3-(4-hydroxyphenyl)propanoyl]-N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pyrrolidine-2-carboxamide
InChIKey
BSXFOBDOGHFWOC-KRCBVYEFSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA monograph or restriction applies to Acetyl Tetrapeptide-15. Used as a cosmetic ingredient under FDA general cosmetic regulations. No GRASE classification — not a sunscreen active. No CIR safety assessment has been published for this ingredient. CIR has reviewed structurally related peptides (Tripeptide-1, Hexapeptide-12, Palmitoyl Tetrapeptide-7) but not Acetyl Tetrapeptide-15 specifically. No VCRP-specific data identified in available literature. Trade name Skinasensyl LS 9749 (Lubrizol/Lipotec). Formulators seeking US market safety substantiation should request the supplier's full toxicological dossier.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Acetyl Tetrapeptide-15.
Calculate MoS for your specific formulation with the MoS Calculator.
Expert Verdict
Expert safety assessment and concern-level summary for Acetyl Tetrapeptide-15.
Regulatory Flags
no-sccs-opinion
no-cir-review
supplier-data-only
high-molecular-weight
peptide
neurotransmitter-inhibitor
sensitive-skin
data-gap-dermal-absorption
data-gap-sensitization
data-gap-mos
Frequently Asked Questions
Is Acetyl Tetrapeptide-15 allowed in the EU?
Acetyl Tetrapeptide-15 EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Acetyl Tetrapeptide-15 do in cosmetics?
Acetyl Tetrapeptide-15 functions as: Skin conditioning, neurotransmitter-inhibiting (mu-opioid receptor agonist, CGRP release inhibition for sensitive skin). It is classified as a cosmetic ingredient in our database. CAS number: 928007-64-1.
Is Acetyl Tetrapeptide-15 used outside cosmetics?
Acetyl Tetrapeptide-15 also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Acetyl Tetrapeptide-15 compliance across multiple jurisdictions:
Ingredient Decoder
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Substance Compliance
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MoS Calculator
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Heavy Metal Limits
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ACETALDEHYDE
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