Is Palmitoyl Oligopeptide safe in cosmetics?
Palmitoyl Oligopeptide has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Palmitoyl Oligopeptide
Also known as: L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-, L-Lysine, N2-[N-[N-(1-oxohexadecyl)glycyl]-L-histidyl]-, N-(1-Oxohexadecyl)glycyl-L-histidyl-L-lysine, 11: PN: WO2007093839 SEQID: 17 claimed protein, Palmitoylglycylhistidyllysine (+3 more)
INCI: PALMITOYL OLIGOPEPTIDE
Palmitoyl Oligopeptide (CAS 147732-56-7) is a cosmetic cosmetic ingredient functioning as Skin conditioning, surfactant-cleansing, anti-aging (ECM protein synthesis. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 147732-56-7 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, surfactant-cleansing, anti-aging (ECM protein synthesis stimulation)
Safety Rating
GOOD
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
No FDA restrictions or GRAS determination applicable. Reported in FDA VCRP 2012 across multiple product categories. CIR Expert Panel published final safety assessment in 2018 concluding safe as used. No specific concentration limits established by CIR or FDA.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Palmitoyl Oligopeptide.
Calculate MoS for your specific formulation with the MoS Calculator.
Additional Ingredient Properties
8 property records from structured ingredient metadata.
amino_acid
{"ingredient_class": "oligopeptide", "source_origin": "synthetic", "molecular_weight_range_Da": "500-1000", "amino_acid_composition_key": "palmitoyl_peptide_blend", "charge_at_pH_5_5": "cationic", "water_solubility": "soluble", "oil_solubility": "partially", "film_forming_ability": "poor", "moisture_binding_capacity": "moderate", "NMF_component": "no", "skin_penetration_depth": "dermis", "hair_bin…
anti_aging
{"anti_aging_claim": "anti-wrinkle, collagen-boosting", "mechanism_of_action": "Stimulates collagen, elastin, GAG synthesis", "target_skin_layer": "dermis", "collagen_stimulation": "Yes", "elastin_protection": "Yes", "wrinkle_reduction_pct": "10-20", "clinical_study_duration_weeks": "12", "sample_size": "40", "double_blind": "Yes", "placebo_controlled": "Yes", "published_journal": "JOCD", "improve…
anti_pollution
{"cas_number": "147732-56-7", "ingredient_class": "other", "primary_mechanism": "barrier_reinforcement", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_kB_inhibi…
hair_care
{"hair_function": "strengthening", "hair_type_suitability": "all", "curl_pattern_suitability": "all", "porosity_suitability": "high", "protein_sensitivity": "protein", "moisture_protein_balance": "yes", "cg_method_approved": "not-a-silicone", "silicone_type": "not-a-sulfate", "sulfate_type": "no", "drying_alcohol": "no", "fatty_alcohol": "no", "heat_protectant": "yes", "color_safe": "strengthens",…
peptide
{"cas_number": "146439-94-3", "trade_name": "Dermaxyl / Pal-KTTKS", "peptide_sequence_amino_acids": "Pal-Lys-Thr-Thr-Lys-Ser", "peptide_length_residues": "5", "molecular_weight_daltons": "802.0", "peptide_class": "signal", "mechanism_of_action": "Same as Matrixyl original, stimulates collagen synthesis", "target_protein_or_receptor": "TGF-beta receptor", "biomimetic_of": "collagen_fragment", "coll…
ph_stability
{"optimal_ph_min": "5.5", "optimal_ph_max": "6.5", "stable_ph_min": "5.0", "stable_ph_max": "7.0", "degrades_above_ph": "7.5", "degrades_below_ph": "4.5", "ph_dependent_function": "Anti-aging peptide", "formulation_note": "Requires neutral pH", "source": "Formulation literature"}
synergy
{"inci_name_2": "Retinol", "synergy_type": "efficacy-boost", "synergy_description": "Multi-chain peptide with retinoid for maximum anti-aging", "combined_benefit": "Enhanced wrinkle reduction, improved texture, comprehensive renewal", "efficacy_multiplier": "2.4x", "mechanism_of_action": "Oligopeptide provides multiple collagen signals; retinol adds gene-level effects", "optimal_ratio": "6:1 (3% p…
uv_stability
{"uv_stable": "yes", "uv_degradation_rate": "stable", "photosensitizer": "no", "phototoxic": "no", "photoallergic": "no", "requires_uv_protection_packaging": "yes", "color_change_uv": "no", "odor_change_uv": "no", "efficacy_loss_uv_pct": "5", "spf_contribution": "no", "uva_protection": "no", "uvb_protection": "no", "photostable_sunscreen": "no", "boost_spf_of_others": "no", "antioxidant_under_uv":…
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Cleaning agent
Softener and conditioner
Surfactant (surface active agent)
Expert Verdict
Expert safety assessment and concern-level summary for Palmitoyl Oligopeptide.
Regulatory Flags
thin-data-package
read-across-safety
no-sccs-opinion
no-formal-mos
nomenclature-ambiguity
cpsr-justification-required
Known Synonyms
L-Lysine, N-(1-oxohexadecyl)glycyl-L-histidyl-
L-Lysine, N2-[N-[N-(1-oxohexadecyl)glycyl]-L-histidyl]-
N-(1-Oxohexadecyl)glycyl-L-histidyl-L-lysine
11: PN: WO2007093839 SEQID: 17 claimed protein
Palmitoylglycylhistidyllysine
Biopeptide CL
Palmitoyl Tripeptide 1
Palmitoyl-GHK tripeptide
Chemical Function
Surfactant (surface active agent)
Softener and conditioner
Cleaning agent
Regulatory Lists
Canada; Personal care; Substances in PCP - Canada (4/2014)
Canada; Personal care; Substances in PCP - Canada (4/2014)
Canada; pharmaceutical
Australian Status
AICIS status: listed_with_terms
Assessment: This chemical has been assessed as a component of dermal cosmetic products at concentrations no more than 0.002%. This chemical is not to be used in the eye.
Frequently Asked Questions
Is Palmitoyl Oligopeptide allowed in the EU?
Palmitoyl Oligopeptide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Palmitoyl Oligopeptide do in cosmetics?
Palmitoyl Oligopeptide functions as: Skin conditioning, surfactant-cleansing, anti-aging (ECM protein synthesis stimulation). It is classified as a cosmetic ingredient in our database. CAS number: 147732-56-7.
Compliance Tools
Check Palmitoyl Oligopeptide compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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OLEOYL TYROSINE
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