Is NONAN-2-ONE safe in cosmetics?
NONAN-2-ONE has a safety rating of "GOOD" in our database. EU status: permitted. US status: prohibited. 3 toxicological study endpoint(s) are available in our database.
NONAN-2-ONE
Also known as: BRN 1743645, EINECS 212-480-0, FEMA No. 2785, Ketone, heptyl methyl, UNII-ZE5K73YN2Z (+4 more)
NONAN-2-ONE (CAS 821-55-6) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 1000 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 821-55-6 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
nonan-2-one
InChIKey
VKCYHJWLYTUGCC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
prohibited
US Notes
Allowed — not prohibited or restricted; also has FEMA GRAS status for flavoring, reinforcing its safety profile
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
3 study endpoints found for NONAN-2-ONE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =7.86 mg/kg bw/day | inhalation | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =102.26 mg/kg bw/day | inhalation | Rat | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for NONAN-2-ONE across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 3375 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
292
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-NONANONE | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/59 | FAS 42-JECFA 51/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
HEPTYL METHYL KETONE | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/59 | FAS 42-JECFA 51/235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for NONAN-2-ONE.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to NONAN-2-ONE by CAS number or substance name.
Studies
15
Lowest NOAEL
7.86 mg/kg bw/day
Highest NOAEL
1000 mg/kg bw/day
ToxValDB_ECHA_IUCLID
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
BRN 1743645
EINECS 212-480-0
FEMA No. 2785
Ketone, heptyl methyl
UNII-ZE5K73YN2Z
NONANONE-2
beta-Nonanone
n-C7H15COCH3
β-Nonanone
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
artificial_sweat; detected; emissions; Europe; Toys and children's products
artificial_sweat; detected; emissions; Europe; Toys and children's products
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
2-NONANONE
ChEMBL ID
CHEMBL2228473
Frequently Asked Questions
Is NONAN-2-ONE allowed in the EU?
NONAN-2-ONE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NONAN-2-ONE do in cosmetics?
NONAN-2-ONE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 821-55-6.
What is the NOAEL for NONAN-2-ONE?
The NOAEL (No Observed Adverse Effect Level) for NONAN-2-ONE is =7.86 mg/kg bw/day based on a reproduction developmental study via inhalation route in Rat. A total of 3 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Is NONAN-2-ONE used outside cosmetics?
NONAN-2-ONE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check NONAN-2-ONE compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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