What is the NOAEL for 2-Nonanone?
2-Nonanone has 16 NOAEL studies in the database. The lowest reported value is ZE5K73YN2Z UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
2-Nonanone
Also known as: BRN 1743645, EINECS 212-480-0, FEMA No. 2785, Ketone, heptyl methyl, UNII-ZE5K73YN2Z (+4 more)
CAS 821-55-6
2-Nonanone (CAS 821-55-6) is a chemical substance. Key regulatory status: REACH registered, 6 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
16
SOURCE
chemical inventory jurisdictions
Regulatory lists
6
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
15 fields
Name
2-Nonanone
CAS Number
821-55-6
DTXSID
DTXSID2022125
Molecular Formula
C9H18O
InChI Key
VKCYHJWLYTUGCC-UHFFFAOYSA-N
Monoisotopic Mass
142.135765
Synonyms
BRN 1743645EINECS 212-480-0FEMA No. 2785Ketone, heptyl methylUNII-ZE5K73YN2ZNONANONE-2beta-Nonanonen-C7H15COCH3β-Nonanone
Functional Uses
Industrial and product-use categories associated with this substance.
SOURCE
EPA CPDat
5 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
6 records
| List | Keyword | Source |
|---|---|---|
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| artificial_sweat; detected; emissions; Europe; Toys and children's products | Danish Environmental Protection Agency | Danish EPA |
| IFRA Transparency | IFRA | IFRA |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
| consumer_product | P&G | Proctor & Gamble |
| Europe | European Commission | Fl@vis |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 16 of 16 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| ZE5K73YN2Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZE5K73YN2Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZE5K73YN2Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| ZE5K73YN2Z | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 3375 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| =3200 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =52359.3 | mg/m3 | LEL | inhalation | Human | ToxValDB_DOE_Protective_Action_Criteria |
| =2000 | mg/kg bw/day | LOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =80000 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =1000000 | mg/m3 | NOAEC | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =7.86 | mg/kg bw/day | NOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =102.26 | mg/kg bw/day | NOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| =1000 | mg/kg bw/day | NOAEL | oral | Rat | ToxValDB_ECHA_IUCLID |
| =5817.7 | mg/m3 | NOAEL | inhalation | Rat | ToxValDB_ECHA_IUCLID |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 16 of 16 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
SOURCE
ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | Nonan-2-one | 212-480-0 | ECHA overview → |
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
permitted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
SOURCE
EMBL-EBI ChEMBL
2-NONANONE
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Food Safety Data
Same-CAS food additive, ADI, and GRAS records where available.
SOURCE
EFSA / FDA GRAS
1 records
ADI: No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
View full food safety profile →Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include 2-Nonanone?
2-Nonanone appears on 5 regulatory/inventory lists including artificial_sweat; detected; emissions; Europe; Toys and children's products, IFRA Transparency, food_additive; Substances Added to Food (formerly EAFUS) (2/2019), and 2 more. Source: EPA CPDat.
Is 2-Nonanone used in cosmetics?
Yes, 2-Nonanone is also indexed as a cosmetic ingredient under the name NONAN-2-ONE. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for 2-Nonanone come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, EFSA / FDA GRAS, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is 2-Nonanone used outside industrial chemicals?
2-Nonanone also appears in cosmetics, pharmaceutical, food safety, cannabis databases.