NOAEL Studies Cosmetic Ingredient

NONAN-2-ONE NOAEL Studies

CAS: 821-55-6

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 =3200 mg/kg bw Rat oral acute Rat Acute Oral Toxicity NLM ChemIDplus TEST (undated); record_id=acute_oral_10756; row=4028; data_type=In Vivo; mixture=Chemical; chemical_name=2-Nonanone; preferred_name=2-Nonanone; dtxsid=DTXSID2022125; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2022125; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10560; Record_ID=skin_sensitization_invivo_2322; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2022125; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Epstein 1980: report to RIFM|Anonymous 1988; Not available; 10.1016/0278-6915(88)90197-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2022125
NTP_ICE_skin_sensitization Induction dose per skin area 3375 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10558; Record_ID=skin_sensitization_invivo_2322; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2022125; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=3375; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Epstein 1980: report to RIFM|Anonymous 1988; Not available; 10.1016/0278-6915(88)90197-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2022125
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10564; Record_ID=skin_sensitization_invivo_2322; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID2022125; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Epstein 1980: report to RIFM|Anonymous 1988; Not available; 10.1016/0278-6915(88)90197-4; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID2022125
ToxValDB_DOE_Protective_Action_Criteria 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_DOE_Protective_Action_Criteria LEL =52359.3 mg/m3 Human inhalation - acute LONG_REF=U.S. Department of Energy (DOE) Protective Action Criteria (PAC). 2023. PAC Chemical Database. Updated 11 October 2023. Available: https://edms3.energy.gov/pac/ (Accessed November 16, 2023); TITLE=U.S. Department of Energy (DOE) Protective Action Criteria (PAC) Chemical Database; AUTHOR=U.S. Department of Energy; STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/65428efee4b045b9ff7cc432; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://edms3.energy.gov/pac/TeelDocs; YEAR=2013; ORIGINAL_YEAR=2013; STUDY_GROUP=DOE Protective Action Criteria:15517944:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_02d737efeeec3303d669230573b55779
ToxValDB_ECHA_IUCLID 7 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
ToxValDB_ECHA_IUCLID LOAEL =2000 mg/kg bw/day Rat oral subchronic; 90 days subchronic QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaf16e4b0a7c65d1cc790; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17523/7/6/2?documentUUID=e37a0502-7ed1-48df-bf79-b441bf98d195; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15838503_15838504_15839353_15839354:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_472f95692a507ec76efe7e4384436ed3
ToxValDB_ECHA_IUCLID NOAEC =80000 mg/m3 Rat inhalation subchronic; 50 days subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17523/7/6/3?documentUUID=e37a0502-7ed1-48df-bf79-b441bf98d195; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829273_15829274:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_28e6e4cc700142477af6d74315f841a9
ToxValDB_ECHA_IUCLID NOAEC =1000000 mg/m3 Rat inhalation subchronic; 50 days subchronic QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66059786e4b063812d6fa765; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17523/7/6/3?documentUUID=e37a0502-7ed1-48df-bf79-b441bf98d195; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Inhalation_15829273_15829274:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_188d92eddd777ff8cac8a626ef98ab96
ToxValDB_ECHA_IUCLID NOAEL =102.26 mg/kg bw/day Rat inhalation - developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d232e4b0a7c65d23205b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17523/7/9/3?documentUUID=e37a0502-7ed1-48df-bf79-b441bf98d195; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes|fetus: external malformations; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15820619:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_bb4d70bdbfd3fb90e952162c1402053f
ToxValDB_ECHA_IUCLID NOAEL =5817.7 mg/m3 Rat inhalation - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7d232e4b0a7c65d23205b; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17523/7/9/3?documentUUID=e37a0502-7ed1-48df-bf79-b441bf98d195; YEAR=2016; ORIGINAL_YEAR=2016; TOXICOLOGICAL_EFFECT=maternal: body weight and weight gain|maternal: gross pathology|maternal: histopathology: non-neoplastic|maternal: mortality|maternal: organ weights and organ / body weight ratios; TOXICOLOGICAL_EFFECT_CATEGORY=body weight|gross pathology|mortality/survival|nonneoplastic histopathology|organ weight; STUDY_GROUP=ECHA IUCLID:15821974:F:-maternal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_a8fff9e529667ba03df1b26772529f1f
ToxValDB_ECHA_IUCLID NOAEL =1000 mg/kg bw/day Rat oral short-term; 3 weeks short-term QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7cbf1e4b0a7c65d22832d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17523/7/6/2?documentUUID=e37a0502-7ed1-48df-bf79-b441bf98d195; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID_dup_Repeated Dose Toxicity Oral_15836636_15841480:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_0931f5352ba3b16e58ade856f02a2442
ToxValDB_ECHA_IUCLID NOAEL =7.86 mg/kg bw/day Rat inhalation - reproduction developmental QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/66a7c95de4b0a7c65d21c97d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/17523/7/9/2?documentUUID=e37a0502-7ed1-48df-bf79-b441bf98d195; YEAR=2016; ORIGINAL_YEAR=2016; STUDY_GROUP=ECHA IUCLID:15857139:M/F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_56e52862771ae628528b0a319f6ef58d
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier ZE5K73YN2Z UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ZE5K73YN2Z"}
openFDA substances FDA UNII substance identifier ZE5K73YN2Z UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ZE5K73YN2Z"}
openFDA substances FDA UNII substance identifier ZE5K73YN2Z UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ZE5K73YN2Z"}
openFDA substances FDA UNII substance identifier ZE5K73YN2Z UNII - - - chemical {"approval_status":null,"molecular_formula":"C9H18O","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"ZE5K73YN2Z"}