Is NEROL OXIDE safe in cosmetics?
NEROL OXIDE has a safety rating of "GOOD" in our database. EU status: permitted. US status: allowed.
Good
Cosmetic Ingredient
NEROL OXIDE
Also known as: 5-17-01-00406, BRN 1562957, 3,6-Dihydro-4-methyl-2-(2-methylpropenyl)-2H-pyran, EINECS 217-241-4, FEMA No. 3661 (+3 more)
NEROL OXIDE (CAS 1786-08-9) is a cosmetic cosmetic ingredient functioning as Perfuming. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 1786-08-9 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
4-methyl-2-(2-methylprop-1-enyl)-3,6-dihydro-2H-pyran
InChIKey
FRISMOQHTLZZRP-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
allowed
US Notes
Allowed — no prohibition or restriction. Used in flavor and fragrance applications.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
6750 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [407] Epstein WL (1980): Report to RIFM, 11 January, unpublished.
HRIPT Human Patch Test Studies
2 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 6750 | - | - |
| HMT | - | 0 | 13500 | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (3)
JECFA Number
1235
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3,6-DIHYDRO-4-METHYL-2-(2-METHYL-1-PROPENYL)-2H-PYRAN | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/86 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
NEROL OXIDE | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/86 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for NEROL OXIDE.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
fda_food_additive
jecfa_safe
Known Synonyms
5-17-01-00406
BRN 1562957
3,6-Dihydro-4-methyl-2-(2-methylpropenyl)-2H-pyran
EINECS 217-241-4
FEMA No. 3661
2H-Pyran, 3,6-dihydro-4-methyl-2-(2-methylpropenyl)-
2H-Pyran, 3,6-dihydro-4-methyl-2-(2-methyl-1-propeyl)-
UNII-NSW8112Y7S
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Europe
IFRA Transparency
Australian Status
AICIS status: listed
Frequently Asked Questions
Is NEROL OXIDE allowed in the EU?
NEROL OXIDE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NEROL OXIDE do in cosmetics?
NEROL OXIDE functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 1786-08-9.
Is NEROL OXIDE used outside cosmetics?
NEROL OXIDE also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check NEROL OXIDE compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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