Is NERAL safe in cosmetics?
NERAL has a safety rating of "GOOD" in our database. EU status: permitted. 7 toxicological study endpoint(s) are available in our database.
NERAL
NERAL (CAS 106-26-3) is a cosmetic cosmetic ingredient functioning as Perfuming. NOAEL 60 mg/kg bw/day (PDF-verified against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 106-26-3 →
Auto-generated CPSR Part A draft with source citations
Chemistry & Identifiers
IUPAC Name
(2Z)-3,7-dimethylocta-2,6-dienal
InChIKey
WTEVQBCEXWBHNA-YFHOEESVSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
7 study endpoints found for NERAL. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =60 mg/kg bw/day | oral | Mouse | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =100 mg/kg bw/day | oral | Rat | chronic | ToxValDB_ECHA_IUCLID |
| NOAEL | =200 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =534 mg/kg bw/day | oral | Mouse | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =570 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =4275 mg/kg bw/day | oral | Mouse | short-term | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for NERAL across SCCS product categories, with measured dermal absorption where available.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 3240 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Intermediate
Tonnage Band
Intermediate use only
Substance Type
SUBSTANCE
SVHC Candidate
No
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (1)
IFRA Fragrance Transparency List
Expert Verdict
Expert safety assessment and concern-level summary for NERAL.
Regulatory Flags
cosing-sourced
eu-permitted
fragrance
needs-enrichment
ifra_fragrance
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to NERAL by CAS number or substance name.
Studies
7
Lowest NOAEL
60 mg/kg bw/day
Highest NOAEL
4275 mg/kg bw/day
ToxValDB_ECHA_IUCLID
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
air; detected; emissions; Europe; Vehicle - car interior
detected; Europe; Vehicle - car interior
IFRA Transparency
Europe
Australian Status
AICIS status: listed
Frequently Asked Questions
Is NERAL allowed in the EU?
NERAL EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does NERAL do in cosmetics?
NERAL functions as: Perfuming. It is classified as a cosmetic ingredient in our database. CAS number: 106-26-3.
What is the NOAEL for NERAL?
The NOAEL (No Observed Adverse Effect Level) for NERAL is =60 mg/kg bw/day based on a chronic study via oral route in Mouse. A total of 7 study endpoints are available. Source: ToxValDB_ECHA_IUCLID.
Compliance Tools
Check NERAL compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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