Is METHYL METHACRYLATE safe in cosmetics?
METHYL METHACRYLATE has a safety rating of "GOOD" in our database. EU status: permitted. 3 toxicological study endpoint(s) are available in our database.
METHYL METHACRYLATE
Also known as: 2-Propenoic acid, 2-methyl-, methyl ester, 4-02-00-01519, Acrylic acid, 2-methyl-, methyl ester, BRN 0605459, EINECS 201-297-1 (+15 more)
METHYL METHACRYLATE (CAS 80-62-6) is a cosmetic cosmetic ingredient functioning as Anticaking, Opacifying. NOAEL 124.1 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 80-62-6 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
METHYL METHACRYLATE is classified GHS Danger (H225, H315, H317, H335, H319, H333, H334, H336) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Anticaking, Opacifying
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
methyl 2-methylprop-2-enoate
InChIKey
VVQNEPGJFQJSBK-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
Not specifically regulated
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Toxicological Studies
3 study endpoints found for METHYL METHACRYLATE. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =146 mg/kg bw/day | oral | - | Chronic toxicity | INCHEM_WHO_cicads_cicads_cicad04 |
| NOAEL | =400 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =450 mg/kg bw/day | oral | Rabbit | developmental | ToxValDB_ECHA_IUCLID |
GHS Hazard Classification
Globally Harmonized System classification per ECHA C&L inventory and ILO/WHO International Chemical Safety Cards.
Short-term Exposure Effects
The substance is irritating to the eyes, skin and respiratory tract.
Long-term Exposure Effects
Repeated or prolonged contact may cause skin sensitization. The substance may have effects on the peripheral nervous system.
Routes of Exposure
The substance can be absorbed into the body by inhalation, through the skin and by ingestion.
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for METHYL METHACRYLATE across SCCS product categories, with measured dermal absorption where available.
Sensitization Profile
Contact sensitization data for METHYL METHACRYLATE based on clinical patch test studies and IFRA standards.
Sensitization Rate
low
Allergen Class
other
EU Allergen Listed
no
Patch Test Positive Rate
0.5%
Cross-reactivity Group
acrylate-group
Reaction Type
contact-dermatitis
Source: IVDK; NACDG
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
Sup 7, 60
Evaluation Year
1994
EU CLP Annex VI Harmonized Classification
Legally binding harmonized classification per Regulation (EC) No 1272/2008 (CLP) Annex VI.
Signal Word
Danger
Pictograms
FlammableHarmful / Irritant
Hazard Class and Category
Flam. Liq. 2; STOT SE 3; Skin Irrit. 2; Skin Sens. 1
Hazard Statements
- H225 Highly flammable liquid and vapour
- H335 May cause respiratory irritation
- H315 Causes skin irritation
- H317 May cause an allergic skin reaction
Inserted via ATP: CLP00
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
DPRA Cys %
42.1%
DPRA Lys %
10%
KeratinoSens IC50
2000 µM
hCLAT CV75
1666.65 µg/mL
LLNA EC3
75%
NESIL
7874 µg/cm²
LLNA: NC (non-sensitizer)
GHS: not classified
Human: positive
Source: LLNA: Kern et al. (2010) | Betts et al. (2006); DPRA: Hoffmann et al., 2018 | Joint Research Centre of the European Union 2013; KS: Natsch et al. 2013 [DOI:10.1002/jat.2868] | Bauch et al. 2011 [DOI:10.1016/j.tiv.2011.05.030]; hCLAT: Bauch et al. 2011 [DOI:10.1016/j.tiv.2011.05.030] | Takenouchi et al. 2013 [DOI:10.2131/jts.38.599]; HPPT: [603] Marzulli FN and Maguire HC (1983): http://www.worldcat.org/oclc/489755491
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HRIPT | - | 0 | 7874.02 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100,000 - 1,000,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Hazard classification: Restricted (Annex XVII)
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (2)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CA | banned | - | - |
| KR | prohibited | - | - |
IFRA Concentration Limits (12 Product Categories)
International Fragrance Association standards per product category. Restriction: Prohibition. Effective: 2008-01-01.
| Category | Max % | Category | Max % |
|---|---|---|---|
| 1 (Lip products) | 0.0% | 7a (Deodorant – not spray) | 0.0% |
| 2 (Body spray) | 0.0% | 7b (Deodorant spray) | 0.0% |
| 3 (Body cream) | 0.0% | 8 (Face cream) | 0.0% |
| 4 (Fine fragrance) | 0.0% | 9 (Soap) | 0.0% |
| 5a (Body lotion) | 0.0% | 10a (Household – non-spray) | 0.0% |
| 5b (Face cream leave-on) | 0.0% | 10b (Household – spray) | 0.0% |
| 5c (Hand cream) | 0.0% | 11a (Intimate – leave-on) | 0.0% |
| 5d (Baby cream) | 0.0% | 11b (Intimate – rinse) | 0.0% |
| 6 (Mouthwash) | 0.0% | 12 (Not for consumer exposure) | 0.0% |
Additional Ingredient Properties
1 property record from structured ingredient metadata.
allergen_detail
{"eu_allergen_listed": "no", "allergen_class": "other", "cross_reactivity_group": "acrylate-group", "patch_test_frequency_pct": "0.5", "sensitization_rate": "low", "common_reaction_type": "contact-dermatitis", "ifra_restricted": "no", "source": "IVDK; NACDG"}
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (6)
Carcinogen Classification
Methyl methacrylate | Group 3: Not classifiable as to its carcinogenicity to humans | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print) | Volume 60: (1994) Some Industrial Chemicals
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
Methyl Methacrylate | TR-314: Toxicology and Carcinogenesis Studies of Methyl Methacrylate (CASRN 80-62-6) in F344/N Rats and B6C3F1 Mice (Inhalation Studies) (1986 ) | 12/09/85 | No Evidence | No Evidence | No Evidence | No Evidence | Under the conditions of these 2-year inhalation studies, there was no evidence of carcinogenicityof methyl methacrylate for male F344/N rats exposed at 500
Source: NTP Technical Reports
Evidence for Carcinogenicity
Evaluation: There is inadequate evidence in humans for the carcinogenicity of methyl methacrylate. There is evidence suggesting lack of carcinogenicity of methyl methacrylate in experimental animals. Overall evaluation: Methyl methacrylate is not classifiable as to its carcinogenicity to humans (Group3). | WEIGHT OF EVIDENCE CHARACTERIZATION: Under EPA's 1986 Guidelines for Carcinogen Risk Assessm
Source: Hazardous Substances Data Bank (HSDB)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
ICSC Safety Card
0300
Source: ILO-WHO International Chemical Safety Cards (ICSCs)
Regulatory (2)
JECFA Number
1834
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
METHYL 2-METHYL-2-PROPENOATE | 2008 | No safety concern at current levels of intake when used as a flavouring agent | ">RS 952-JECFA 69/80 | ">FAS 60-JECFA 69/291
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Adhesion/cohesion promoter
Anti-caking agent
Binder
Flavouring and nutrient
Fragrance
Monomers
No specific technical function
Opacifer
Processing aids not otherwise specified
Surface modifier
Regulatory List Membership (3)
FDA Substances Added to Food (EAFUS)
FDA Indirect Food Contact Additives
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for METHYL METHACRYLATE.
Regulatory Flags
cosing-sourced
eu-permitted
needs-enrichment
endocrine_disruptor
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to METHYL METHACRYLATE by CAS number or substance name.
Studies
12
Lowest NOAEL
38 mg/kg bw/day
Highest NOAEL
450 mg/kg bw/day
ToxValDB_ECHA_IUCLID
INCHEM_WHO_cicads_cicads_cicad04
ECHA_REACH_reach_study_results_dossiers_23-05-2023.zip
Known Synonyms
2-Propenoic acid, 2-methyl-, methyl ester
4-02-00-01519
Acrylic acid, 2-methyl-, methyl ester
BRN 0605459
EINECS 201-297-1
Methyl methacrylate monomer
2-Methylacrylic acid, methyl ester
"monocite" Methacrylate monomer
NCI-C50680
RCRA waste number U162
Metakrylan metylu
Methylester kyseliny methakrylove
Methylmethacrylaat
Metil metacrilato
UNII-196OC77688
Kallocryl A
Simplex P
2-Methylacrylic acid methyl ester
MMA
Methacrylsaeuremethyl ester
Chemical Function
Opacifer
Anti-caking agent
Binder
Flavouring and nutrient
Regulatory Lists
air; detected; emissions; Europe; Toys and children's products
air; Cons electronics mech appliances and machinery; detected; emissions; Europe
Arts and crafts/Office supplies - fabric treatment and dye; detected
drinking_water; Europe; manufacturing; plastic_additive
inert_ingredient; non_food_use; Pesticides
CEDI
Indirect additives food contact (10/2018)
Cons electronics mech appliances and machinery; detected; Europe
Cons electronics mech appliances and machinery; detected; Europe
Cons electronics mech appliances and machinery; detected; Europe
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
air; Cons electronics mech appliances and machinery; detected; emissions; Europe
Arts and crafts/Office supplies - general arts and crafts supplies - arts and crafts paint; Europe
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL49996
Frequently Asked Questions
Is METHYL METHACRYLATE allowed in the EU?
METHYL METHACRYLATE EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does METHYL METHACRYLATE do in cosmetics?
METHYL METHACRYLATE functions as: Anticaking, Opacifying. It is classified as a cosmetic ingredient in our database. CAS number: 80-62-6.
What is the NOAEL for METHYL METHACRYLATE?
The NOAEL (No Observed Adverse Effect Level) for METHYL METHACRYLATE is =146 mg/kg bw/day based on a Chronic toxicity study via oral route in rat. A total of 3 study endpoints are available. Source: INCHEM_WHO_cicads_cicads_cicad04.
Is METHYL METHACRYLATE used outside cosmetics?
METHYL METHACRYLATE also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does METHYL METHACRYLATE have different safety status in cosmetics vs industrial chemicals?
METHYL METHACRYLATE is classified GHS Danger (H225, H315, H317, H335, H319, H333, H334, H336) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
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Ingredient Decoder
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82 Allergen Checker
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Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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