Is Methyl Caproate safe in cosmetics?
Methyl Caproate has a safety rating of "GOOD" in our database. EU status: restricted. US status: permitted.
Good
Cosmetic Ingredient
Methyl Caproate
Also known as: BRN 1744683, EINECS 203-425-1, FEMA No. 2708, UNII-246364VPJS, Caproic acid methyl ester (+7 more)
INCI: METHYL CAPROATE
Methyl Caproate (CAS 106-70-7) is a cosmetic cosmetic ingredient functioning as Fragrance ingredient; skin conditioning (emollient). EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and food safety data.
View industrial chemical safety profile for CAS 106-70-7 →
Auto-generated CPSR Part A draft with source citations
Function
Fragrance ingredient; skin conditioning (emollient)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
methyl hexanoate
InChIKey
NUKZAGXMHTUAFE-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Permitted — no CFR prohibition for cosmetic use; FDA GRAS under 21 CFR 172.515 for flavoring; FEMA 2708
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Methyl Caproate.
Calculate MoS for your specific formulation with the MoS Calculator.
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 2700 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
10 - 100 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (2)
JECFA Number
1871
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
METHYL HEXANOATE | 2008 | No safety concern at current levels of intake when used as a flavouring agent | ">RS 952-JECFA 69/108 | ">FAS 60-JECFA 69/623
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Softener and conditioner
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Methyl Caproate.
Regulatory Flags
fragrance-component
ifra_fragrance
fda_food_additive
Known Synonyms
BRN 1744683
EINECS 203-425-1
FEMA No. 2708
UNII-246364VPJS
Caproic acid methyl ester
Caproic acid, methyl ester
FEMA 2708
Hexanoic acid,methyl ester
Methyl N-hexoate
Methyl ester of hexanoic acid
Methyl hexylate
N-Caproic acid methyl ester
Chemical Function
Softener and conditioner
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Cross-Vertical Safety Context
Same-CAS public records found in food safety data.
SOURCE
EFSA / FDA GRAS
food_additives
Food Safety Data
Same-CAS food additive or FDA GRAS records from the core public database.
Food Name
METHYL HEXANOATE
ADI
No safety concern at current levels of intake when used as a flavouring agent mg/kg bw
Food Category
flavoring
Frequently Asked Questions
Is Methyl Caproate allowed in the EU?
Methyl Caproate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Methyl Caproate do in cosmetics?
Methyl Caproate functions as: Fragrance ingredient; skin conditioning (emollient). It is classified as a cosmetic ingredient in our database. CAS number: 106-70-7.
Is Methyl Caproate used outside cosmetics?
Methyl Caproate also appears in industrial chemical safety and food safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Methyl Caproate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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