Is Linalyl Isobutyrate safe in cosmetics?
Linalyl Isobutyrate has a safety rating of "MODERATE" in our database. EU status: restricted. US status: permitted. 2 toxicological study endpoint(s) are available in our database.
Linalyl Isobutyrate
Also known as: Propanoic acid, 2-methyl-, 1-ethenyl-1,5-dimethyl-4-hexen-1-yl ester, 4-02-00-00849, BRN 1726378, 3,7-Dimethyl-1,6-octadien-3-yl isobutanoate, 3,7-Dimethyl-1,6-octadienyl isobutyrate (+13 more)
INCI: LINALYL ISOBUTYRATE
Linalyl Isobutyrate (CAS 78-35-3) is a cosmetic cosmetic ingredient functioning as Perfuming / Fragrance - enhances the top note of compositions, especially. Reported NOAEL =117 mg/kg bw/day in Rat (EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx); EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 78-35-3 →
Auto-generated CPSR Part A draft with source citations
Function
Perfuming / Fragrance - enhances the top note of compositions, especially lavender, cologne, and fruity blends
Safety Rating
MODERATE
Chemistry & Identifiers
IUPAC Name
3,7-dimethylocta-1,6-dien-3-yl 2-methylpropanoate
InChIKey
JZIARAQCPRDGAC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
restricted
US US Status
permitted
US Notes
Allowed - listed on the FDA's Substances Added to Food (formerly EAFUS) list, indicating GRAS/FEMA acceptance for flavor use; not prohibited or restricted for cosmetic use.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Linalyl Isobutyrate.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
2 study endpoints found for Linalyl Isobutyrate. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | =117 mg/kg bw/day | oral: unspecified | Rat | short-term toxicity | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
| NOAEL | =117 mg/kg bw/day | oral: unspecified | Rat | short-term toxicity | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
HRIPT Human Patch Test Studies
1 human repeat insult patch test aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 5184 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Regulatory (4)
JECFA Number
362
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
3,7-DIMETHYLOCTA-1,6-DIEN-3-YL ISOBUTYRATE | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/79 | FAS 42-JECFA 51/293
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
LINALOOL ISOBUTYRATE | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/79 | FAS 42-JECFA 51/293
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
LINALYL ISOBUTYRATE | 1998 | No safety concern at current levels of intake when used as a flavouring agent | TRS 891-JECFA 51/79 | FAS 42-JECFA 51/293
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Flavouring and nutrient
Fragrance
Regulatory List Membership (2)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Expert Verdict
Expert safety assessment and concern-level summary for Linalyl Isobutyrate.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
jecfa_safe
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Linalyl Isobutyrate by CAS number or substance name.
Studies
2
Lowest NOAEL
117 mg/kg bw/day
Highest NOAEL
117 mg/kg bw/day
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx
Known Synonyms
Propanoic acid, 2-methyl-, 1-ethenyl-1,5-dimethyl-4-hexen-1-yl ester
4-02-00-00849
BRN 1726378
3,7-Dimethyl-1,6-octadien-3-yl isobutanoate
3,7-Dimethyl-1,6-octadienyl isobutyrate
3,7-Dimethyl-1,6-octadien-3-yl 2-methylpropanoate
1,5-Dimethyl-1-vinyl-4-hexenyl isobutyrate
EINECS 201-108-2
EINECS 305-132-5
1-Ethenyl-1,5-dimethyl-4-hexenyl 2-methylpropanoate
FEMA No. 2640
Isobutyric acid, linalyl ester
Linalool isobutyrate
Linalyl 2-methylpropanoate
NSC 46145
1,6-Octadien-3-ol, 3,7-dimethyl-, isobutyrate
3,7-Dimethyl-1,6-octadien-3-ol isobutyrate
UNII-8867Y4G46L
Chemical Function
Fragrance
Flavouring and nutrient
Regulatory Lists
IFRA Transparency
Europe
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
ChEMBL ID
CHEMBL3185164
Frequently Asked Questions
Is Linalyl Isobutyrate allowed in the EU?
Linalyl Isobutyrate EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Linalyl Isobutyrate do in cosmetics?
Linalyl Isobutyrate functions as: Perfuming / Fragrance - enhances the top note of compositions, especially lavender, cologne, and fruity blends. It is classified as a cosmetic ingredient in our database. CAS number: 78-35-3.
What is the NOAEL for Linalyl Isobutyrate?
The NOAEL (No Observed Adverse Effect Level) for Linalyl Isobutyrate is =117 mg/kg bw/day based on a short-term toxicity study via oral: unspecified route in Rat. A total of 2 study endpoints are available. Source: EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx.
Is Linalyl Isobutyrate used outside cosmetics?
Linalyl Isobutyrate also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Linalyl Isobutyrate compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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