NOAEL Studies Cosmetic Ingredient

Linalyl Isobutyrate NOAEL Studies

INCI: LINALYL ISOBUTYRATE

CAS: 78-35-3

Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.

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COSMOS_DB 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
COSMOS_DB NOAEL 1000 mg/kg bw/day rat oral 126 day Subchronic US FDA CFSAN PAFA; US FDA CFSAN PAFA Study
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx 2 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx NOAEL =117 mg/kg bw/day Rat oral: unspecified 28 days short-term toxicity ENDPOINTSTUDY_ID 696081; TOX_ID 6775 - OP_ID 2155 - EFSA FEEDAP - 2012 - Scientific Opinion on the safety and efficacy of aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols and esters with esters containing tertiary alcohols ethers (chemical group 6) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2966
EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx NOAEL =117 mg/kg bw/day Rat oral: unspecified 28 days short-term toxicity ENDPOINTSTUDY_ID 696081; TOX_ID 6775 - OP_ID 2155 - EFSA FEEDAP - 2012 - Scientific Opinion on the safety and efficacy of aliphatic, alicyclic and aromatic saturated and unsaturated tertiary alcohols and esters with esters containing tertiary alcohols ethers (chemical group 6) when used as flavourings for all animal species - doi:10.2903/j.efsa.2012.2966
NTP_ICE_acute_oral 1 endpoint
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_acute_oral LD50 >36300 mg/kg bw Rat oral acute Rat Acute Oral Toxicity record_id=acute_oral_10299; row=10960; data_type=In Vivo; mixture=Chemical; chemical_name=Linalyl isobutyrate; preferred_name=Linalyl isobutyrate; dtxsid=DTXSID6047490; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6047490; source_file=acute_oral.xlsx
NTP_ICE_skin_sensitization 3 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
NTP_ICE_skin_sensitization Incidence of positive responses 0 % Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10285; Record_ID=skin_sensitization_invivo_2264; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6047490; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1975; Not available; 10.1016/0015-6264(75)90241-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6047490
NTP_ICE_skin_sensitization Induction dose per skin area 5184 ug/cm2 Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10282; Record_ID=skin_sensitization_invivo_2264; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6047490; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=5184; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1975; Not available; 10.1016/0015-6264(75)90241-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6047490
NTP_ICE_skin_sensitization Relative reliability score 3 unitless Human Dermal - In Vivo; HPPT2020WIP; Human Maximization Test sheet=Data_invivo; excel_row=10290; Record_ID=skin_sensitization_invivo_2264; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=8.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID6047490; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1974: report to RIFM|RIFM 1974; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Opdyke 1975; Not available; 10.1016/0015-6264(75)90241-2; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID6047490
openFDA substances 4 endpoints
Source Endpoint Type Value Unit Species Route Duration Study Type Reference
openFDA substances FDA UNII substance identifier 8867Y4G46L UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H24O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8867Y4G46L"}
openFDA substances FDA UNII substance identifier 8867Y4G46L UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H24O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8867Y4G46L"}
openFDA substances FDA UNII substance identifier 8867Y4G46L UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H24O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8867Y4G46L"}
openFDA substances FDA UNII substance identifier 8867Y4G46L UNII - - - chemical {"approval_status":null,"molecular_formula":"C14H24O2","source_table":"substance_identifiers_fda","substance_class":"chemical","unii_code":"8867Y4G46L"}