What is the NOAEL for Linalyl isobutyrate?
Linalyl isobutyrate has 11 NOAEL studies in the database. The lowest reported value is 8867Y4G46L UNII. Source: openFDA substances.
NOAEL Data
REACH Registered
Cosmetic Ingredient
Linalyl isobutyrate
Also known as: Propanoic acid, 2-methyl-, 1-ethenyl-1,5-dimethyl-4-hexen-1-yl ester, 4-02-00-00849, BRN 1726378, 3,7-Dimethyl-1,6-octadien-3-yl isobutanoate, 3,7-Dimethyl-1,6-octadienyl isobutyrate (+13 more)
CAS 78-35-3
Linalyl isobutyrate (CAS 78-35-3) is a chemical substance. Key regulatory status: REACH registered, 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, ECHA REACH.
SOURCE
noael studies public
NOAEL studies
11
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
24 fields
Name
Linalyl isobutyrate
CAS Number
78-35-3
DTXSID
DTXSID6047490
Molecular Formula
C14H24O2
InChI Key
JZIARAQCPRDGAC-UHFFFAOYSA-N
Monoisotopic Mass
224.17763
Synonyms
Propanoic acid, 2-methyl-, 1-ethenyl-1,5-dimethyl-4-hexen-1-yl ester4-02-00-00849BRN 17263783,7-Dimethyl-1,6-octadien-3-yl isobutanoate3,7-Dimethyl-1,6-octadienyl isobutyrate3,7-Dimethyl-1,6-octadien-3-yl 2-methylpropanoate1,5-Dimethyl-1-vinyl-4-hexenyl isobutyrateEINECS 201-108-2EINECS 305-132-51-Ethenyl-1,5-dimethyl-4-hexenyl 2-methylpropanoateFEMA No. 2640Isobutyric acid, linalyl ester
Functional Uses
Industrial and product-use categories associated with this substance.
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EPA CPDat
4 records
FragranceFlavouring and nutrient
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
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EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| IFRA Transparency | IFRA | IFRA |
| Europe | European Commission | Fl@vis |
| food_additive; Substances Added to Food (formerly EAFUS) (2/2019) | FDA | United States Food and Drug Administration (FDA) |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
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NOAEL studies
Showing 11 of 11 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 8867Y4G46L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8867Y4G46L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8867Y4G46L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| 8867Y4G46L | UNII | FDA UNII substance identifier | - | - | openFDA substances |
| - | % | Incidence of positive responses | Dermal | Human | NTP_ICE_skin_sensitization |
| 5184 | ug/cm2 | Induction dose per skin area | Dermal | Human | NTP_ICE_skin_sensitization |
| >36300 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| =117 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
| =117 | mg/kg bw/day | NOAEL | oral: unspecified | Rat | EFSA_OpenFoodTox_OpenFoodToxTX22809_2023.xlsx |
| 1000 | mg/kg bw/day | NOAEL | oral | rat | COSMOS_DB |
| 3 | unitless | Relative reliability score | Dermal | Human | NTP_ICE_skin_sensitization |
Showing 11 of 11 studies
REACH Registration
Registration status from the ECHA REACH registered substances database.
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ECHA (EU)
1 records
| Status | Name | EC Number | Link |
|---|---|---|---|
| Registered | 1,5-dimethyl-1-vinylhex-4-enyl isobutyrate | 201-108-2 | ECHA overview → |
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
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CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Fragrance
Pharmaceutical Data
Same-CAS pharmaceutical records from drug and bioactivity sources.
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EMBL-EBI ChEMBL
CHEMBL3185164
ChEMBL Phase
Not listed
Adverse Events
0
Bioactivity
0
Cannabis Data
Same-CAS cannabis compliance and lab records where available.
SOURCE
Cannabis regulatory / lab data
efsa substances
1 cannabis record found in efsa substances.
View full cannabis profile →Frequently Asked Questions
What regulatory lists include Linalyl isobutyrate?
Linalyl isobutyrate appears on 3 regulatory/inventory lists including IFRA Transparency, Europe, food_additive; Substances Added to Food (formerly EAFUS) (2/2019). Source: EPA CPDat.
Is Linalyl isobutyrate used in cosmetics?
Yes, Linalyl isobutyrate is also indexed as a cosmetic ingredient under the name Linalyl Isobutyrate. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Linalyl isobutyrate come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, ChEMBL / DailyMed, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.
Is Linalyl isobutyrate used outside industrial chemicals?
Linalyl isobutyrate also appears in cosmetics, pharmaceutical, cannabis databases.