Is Laevo-Rose Oxide safe in cosmetics?
Laevo-Rose Oxide has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted. 6 toxicological study endpoint(s) are available in our database.
Laevo-Rose Oxide
Also known as: 5-17-01-00256, BRN 0111348, EINECS 240-457-5, FEMA No. 3236, Pyran, 2-(2-methyl-1-propenyl)-4-methyltetrahydro- (+11 more)
INCI: LAEVO-ROSE OXIDE
Laevo-Rose Oxide (CAS 16409-43-1) is a cosmetic cosmetic ingredient functioning as Fragrance (declared as PARFUM on label). NOAEL 2.51 mg/kg bw/day (cross-referenced against ToxValDB ECHA IUCLID); EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety data.
View industrial chemical safety profile for CAS 16409-43-1 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Laevo-Rose Oxide is classified GHS CMR hazard (H315, H319, H361) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Fragrance (declared as PARFUM on label)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
4-methyl-2-(2-methylprop-1-enyl)oxane
InChIKey
CZCBTSFUTPZVKJ-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — FEMA GRAS 3236; not restricted under 21 CFR
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Laevo-Rose Oxide.
Calculate MoS for your specific formulation with the MoS Calculator.
Toxicological Studies
6 study endpoints found for Laevo-Rose Oxide. NOAEL (No Observed Adverse Effect Level) values are used to calculate the Margin of Safety per SCCS methodology.
| Endpoint | Value | Route | Species | Study Type | Source |
|---|---|---|---|---|---|
| NOAEL | 2.805 mg/kg bw/day | oral | rat | Subchronic | COSMOS_DB |
| NOAEL | =50 mg/kg bw/day | oral | Rat | developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =100 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =300 mg/kg bw/day | oral | Rat | short-term | ToxValDB_ECHA_IUCLID |
| NOAEL | =1000 mg/kg bw/day | oral | Rat | reproduction developmental | ToxValDB_ECHA_IUCLID |
| NOAEL | =1152 mg/kg bw/day | oral | Rat | subchronic | ToxValDB_ECHA_IUCLID |
Pre-Calculated Safety Assessment
Pre-calculated NOAEL → SED → MoS audit trail for Laevo-Rose Oxide across SCCS product categories, with measured dermal absorption where available.
Sensitization AOP Dashboard
Adverse Outcome Pathway data across 5 assays (DPRA, KeratinoSens, hCLAT, LLNA, NESIL) aggregated from public sources.
NESIL
775 µg/cm²
GHS: 1B
Human: positive
Source: HPPT: [395] Kligman AM (1978): Report to RIFM, 14 July, unpublished.
HRIPT Human Patch Test Studies
3 human repeat insult patch tests aggregated from dermatological literature.
| Test Type | N | Sensitized | Dose µg/cm² | NESIL µg/cm² | Potency |
|---|---|---|---|---|---|
| HMT | - | 0 | 1350 | - | - |
| HRIPT | - | 0 | 775 | - | - |
| HRIPT | - | 0 | 4650.01 | - | - |
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
100 - 1,000 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Regulatory (4)
JECFA Number
1237
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
ROSE OXIDE | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/86 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
2-ISOBUTENYL-4-METHYLTETRAHYDROPYRAN | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/86 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
JECFA Evaluation
TETRAHYDRO-4-METHYL-2-(2-METHYLPROPEN-1-YL)PYRAN | 2003 | No safety concern at current levels of intake when used as a flavouring agent | TRS 922-JECFA 61/86 | FAS 52-JECFA 61/335
Source: Joint FAO/WHO Expert Committee on Food Additives (JECFA)
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Deodorizer
Flavouring and nutrient
Fragrance
Regulatory List Membership (3)
IFRA Fragrance Transparency List
FDA Substances Added to Food (EAFUS)
Consumer Product Chemical
Expert Verdict
Expert safety assessment and concern-level summary for Laevo-Rose Oxide.
Regulatory Flags
potential-allergen
fragrance-component
ifra_fragrance
fda_food_additive
NOAEL Studies Summary
View details ->Public NOAEL study rows linked to Laevo-Rose Oxide by CAS number or substance name.
Studies
6
Lowest NOAEL
2.805 mg/kg bw/day
Highest NOAEL
1152 mg/kg bw/day
COSMOS_DB
ToxValDB_ECHA_IUCLID
Known Synonyms
5-17-01-00256
BRN 0111348
EINECS 240-457-5
FEMA No. 3236
Pyran, 2-(2-methyl-1-propenyl)-4-methyltetrahydro-
2H-Pyran, tetrahydro-4-methyl-2-(2-methylpropenyl)-
Pyran, tetrahydro-4-methyl-2-(2-methylpropenyl)-
Rosenoxide
Rosoxide
Tetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyran
Tetrahydro-4-methyl-2-(2-methylpropenyl)-2H-pyran
UNII-4O51437J50
4-methyl-2-(2-methyl-1-propenyl)tetrahydro-2H-pyran
tetrahydro-4-methyl-2-(2-methyl-1-propenyl)-2H-pyran
tetrahydro-4-methyl-2-(2-methylprop-1-enyl)pyran
rose oxide
Chemical Function
Fragrance
Deodorizer
Flavouring and nutrient
Regulatory Lists
Europe
air; Cleaning products and household care - laundry and fabric treatment; detected; emissions
air; Cleaning products and household care; detected; emissions
air; Cleaning products and household care - air freshener; detected; emissions
IFRA Transparency
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)
consumer_product
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Laevo-Rose Oxide allowed in the EU?
Laevo-Rose Oxide EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Laevo-Rose Oxide do in cosmetics?
Laevo-Rose Oxide functions as: Fragrance (declared as PARFUM on label). It is classified as a cosmetic ingredient in our database. CAS number: 16409-43-1.
What is the NOAEL for Laevo-Rose Oxide?
The NOAEL (No Observed Adverse Effect Level) for Laevo-Rose Oxide is 2.805 mg/kg bw/day based on a Subchronic study via oral route in rat. A total of 6 study endpoints are available. Source: COSMOS_DB.
Is Laevo-Rose Oxide used outside cosmetics?
Laevo-Rose Oxide also appears in industrial chemical safety data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Laevo-Rose Oxide have different safety status in cosmetics vs industrial chemicals?
Laevo-Rose Oxide is classified GHS CMR hazard (H315, H319, H361) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Laevo-Rose Oxide compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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