NOAEL Studies
Cosmetic Ingredient
Laevo-Rose Oxide NOAEL Studies
INCI: LAEVO-ROSE OXIDE
CAS: 16409-43-1
Raw No Observed Adverse Effect Level endpoint records grouped by source. This page does not render calculated Margin of Safety values.
COSMOS_DB 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| COSMOS_DB | NOAEL | 2.805 | mg/kg bw/day | rat | oral | 90 day | Subchronic | US FDA CFSAN PAFA; US FDA CFSAN PAFA Study |
NTP_ICE_acute_oral 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_acute_oral | LD50 | =4300 | mg/kg bw | Rat | oral | acute | Rat Acute Oral Toxicity | NLM ChemIDplus TEST (undated); record_id=acute_oral_3193; row=3270; data_type=In Vivo; mixture=Chemical; chemical_name=4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran; preferred_name=4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran; dtxsid=DTXSID1051771; url=https://chem.nlm.nih.gov/chemidplus/; url_comptox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771; source_file=acute_oral.xlsx |
NTP_ICE_skin_sensitization 10 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| NTP_ICE_skin_sensitization | Concentration, 5% incidence of positive responses | 2.55 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5731; Record_ID=skin_sensitization_invivo_1323; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, 5% incidence of positive responses; Response=2.55; Response_Unit=%; Species=Human; Route=Dermal; Reference=Givaudan 1965: personal communication to RIFM|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771 |
| NTP_ICE_skin_sensitization | Concentration, one positive response | 1 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5727; Record_ID=skin_sensitization_invivo_1323; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Repeat Insult Patch Test; Endpoint=Concentration, one positive response; Response=1; Response_Unit=%; Species=Human; Route=Dermal; Reference=Givaudan 1965: personal communication to RIFM|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 0 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=5720; Record_ID=skin_sensitization_invivo_1322; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Maximization Test; Endpoint=Incidence of positive responses; Response=0; Response_Unit=%; Species=Human; Route=Dermal; Reference=Kligman 1978: report to RIFM|RIFM 1978; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771 |
| NTP_ICE_skin_sensitization | Incidence of positive responses | 9.804 | % | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5723; Record_ID=skin_sensitization_invivo_1323; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Repeat Insult Patch Test; Endpoint=Incidence of positive responses; Response=9.804; Response_Unit=%; Species=Human; Route=Dermal; Reference=Givaudan 1965: personal communication to RIFM|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 1350 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=5718; Record_ID=skin_sensitization_invivo_1322; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Maximization Test; Endpoint=Induction dose per skin area; Response=1350; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Kligman 1978: report to RIFM|RIFM 1978; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 775 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5724; Record_ID=skin_sensitization_invivo_1324; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=1.25; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=775; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=IFF 1964: personal communication to RIFM|RIFM 1964; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771 |
| NTP_ICE_skin_sensitization | Induction dose per skin area | 4650 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5732; Record_ID=skin_sensitization_invivo_1323; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area; Response=4650; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Givaudan 1965: personal communication to RIFM|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, 5% incidence of positive responses | 2372 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5733; Record_ID=skin_sensitization_invivo_1323; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, 5% incidence of positive responses; Response=2372; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Givaudan 1965: personal communication to RIFM|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771 |
| NTP_ICE_skin_sensitization | Induction dose per skin area, one positive response | 930 | ug/cm2 | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Repeat Insult Patch Test | sheet=Data_invivo; excel_row=5729; Record_ID=skin_sensitization_invivo_1323; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=5.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Repeat Insult Patch Test; Endpoint=Induction dose per skin area, one positive response; Response=930; Response_Unit=ug/cm2; Species=Human; Route=Dermal; Reference=Givaudan 1965: personal communication to RIFM|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771 |
| NTP_ICE_skin_sensitization | Relative reliability score | 3 | unitless | Human | Dermal | - | In Vivo; HPPT2020WIP; Human Maximization Test | sheet=Data_invivo; excel_row=5722; Record_ID=skin_sensitization_invivo_1322; Data_Type=In Vivo; Internal_Data_Source=HPPT2020WIP; Concentration=2.0; Concentration_Units=%; Mixture=Chemical; DTXSID=DTXSID1051771; Assay=Human Maximization Test; Endpoint=Relative reliability score; Response=3; Response_Unit=Unitless; Species=Human; Route=Dermal; Reference=Kligman 1978: report to RIFM|RIFM 1978; https://www.rifm.org/rifm-science-database.php#gsc.tab=0|Anonymous 1992; Not available; 10.1016/0278-6915(92)90268-P; URL_CompTox=https://comptox.epa.gov/dashboard/chemical/details/DTXSID1051771 |
ToxValDB_ECHA_IUCLID 7 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_ECHA_IUCLID | NOAEL | =50 | mg/kg bw/day | Rat | oral | - | developmental | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eabf4e4b0a7c65d1bca41; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19099/7/9/3?documentUUID=6a958b27-958a-40da-ab5c-ff09ea1cad4e; YEAR=1993; ORIGINAL_YEAR=1993; TOXICOLOGICAL_EFFECT=fetus: fetal/pup body weight changes; TOXICOLOGICAL_EFFECT_CATEGORY=development; STUDY_GROUP=ECHA IUCLID:15824440:M/F:-fetal; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_86c9a334e4cd450a483f0be9b931f0a4 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1152 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c5249; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19099/7/6/2?documentUUID=6a958b27-958a-40da-ab5c-ff09ea1cad4e; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15848079:M/F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_ddecedc682efda0d1f4046054e9c4c56 |
| ToxValDB_ECHA_IUCLID | NOAEL | >2.81 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c5246; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19099/7/6/2?documentUUID=6a958b27-958a-40da-ab5c-ff09ea1cad4e; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15849168:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_8ca70695644fbd347b3649a4ef71b2ce |
| ToxValDB_ECHA_IUCLID | NOAEL | >2.51 | mg/kg bw/day | Rat | oral | subchronic; 90 days | subchronic | QUALITY=4 (not assignable); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c5246; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19099/7/6/2?documentUUID=6a958b27-958a-40da-ab5c-ff09ea1cad4e; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15849169:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_66f91e2f1662d787d1a69c34182c34ec |
| ToxValDB_ECHA_IUCLID | NOAEL | =300 | mg/kg bw/day | Rat | oral | short-term; 4 weeks | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c524d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19099/7/6/2?documentUUID=6a958b27-958a-40da-ab5c-ff09ea1cad4e; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15849170:F:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_3b4a32a4659582f2c85a8cbd8dba4ac5 |
| ToxValDB_ECHA_IUCLID | NOAEL | =100 | mg/kg bw/day | Rat | oral | short-term; 4 weeks | short-term | QUALITY=1 (reliable without restriction); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eada2e4b0a7c65d1c524d; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19099/7/6/2?documentUUID=6a958b27-958a-40da-ab5c-ff09ea1cad4e; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15849171:M:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_1ee7ece9ff3a0b9d71393cecbf70a974 |
| ToxValDB_ECHA_IUCLID | NOAEL | =1000 | mg/kg bw/day | Rat | oral | - | reproduction developmental | QUALITY=2 (reliable with restrictions); STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/669eaab5e4b0a7c65d1b7129; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://echa.europa.eu/; SUBSOURCE_URL=https://echa.europa.eu/registration-dossier/-/registered-dossier/19099/7/9/2?documentUUID=6a958b27-958a-40da-ab5c-ff09ea1cad4e; YEAR=1993; ORIGINAL_YEAR=1993; STUDY_GROUP=ECHA IUCLID:15862671:F:P0-; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, and this record was expert reviewed; QC_STATUS=pass; SOURCE_HASH=ToxValhc_bcaf5cd168a2b26cf9c5dd21f0ed0178 |
ToxValDB_GESTIS_DNEL 1 endpoint
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| ToxValDB_GESTIS_DNEL | DNEL systemic | =1.2 | mg/m3 | Human | inhalation | - | Toxicity Value | STORED_SOURCE_RECORD=https://clowder.edap-cluster.com/files/6543dd69e4b045b9ff7cd87e; RECORD_SOURCE_LEVEL=Extraction document; SOURCE_URL=https://www.dguv.de/ifa/gestis/gestis-dnel-liste/index-2.jsp; STUDY_GROUP=GESTIS DNEL:15635127:-:--; QC_CATEGORY=Programmatically extracted from structured data source; Source overall passed QC, but this record was not manually checked; QC_STATUS=not determined; SOURCE_HASH=ToxValhc_ec542f58e565435b61b2c0c0c6fb9b0d |
openFDA substances 4 endpoints
| Source | Endpoint Type | Value | Unit | Species | Route | Duration | Study Type | Reference |
|---|---|---|---|---|---|---|---|---|
| openFDA substances | FDA UNII substance identifier | 4O51437J50 | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"4O51437J50"} |
| openFDA substances | FDA UNII substance identifier | 4O51437J50 | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"4O51437J50"} |
| openFDA substances | FDA UNII substance identifier | 4O51437J50 | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"4O51437J50"} |
| openFDA substances | FDA UNII substance identifier | 4O51437J50 | UNII | - | - | - | mixture | {"approval_status":null,"molecular_formula":null,"source_table":"substance_identifiers_fda","substance_class":"mixture","unii_code":"4O51437J50"} |