NOAEL Data REACH Registered Cosmetic Ingredient

4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran

Also known as: 5-17-01-00256, BRN 0111348, EINECS 240-457-5, FEMA No. 3236, Pyran, 2-(2-methyl-1-propenyl)-4-methyltetrahydro- (+11 more)

CAS 16409-43-1

4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran (CAS 16409-43-1) is a chemical substance. Key regulatory status: REACH registered, 7 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, ECHA REACH.

View cosmetic safety profile for Laevo-Rose Oxide →

Cross-Vertical Regulatory Divergence

4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran is classified GHS CMR hazard (H315, H319, H361) in the chemicals database but is allowed in EU cosmetics.

SOURCE Cross-vertical comparison Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code

SOURCE noael studies public

NOAEL studies

SOURCE chemical inventory jurisdictions

Regulatory lists

SOURCE eu clp annex vi

GHS signal

Not classified

Chemical Identity

CAS, identifiers, formula, and alternate names for the matched substance record.

SOURCE DSSTox identifiers 22 fields

Name

4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran

CAS Number

16409-43-1

DTXSID

DTXSID1051771

Molecular Formula

C10H18O

InChI Key

CZCBTSFUTPZVKJ-UHFFFAOYSA-N

Monoisotopic Mass

154.135765

Synonyms

5-17-01-00256BRN 0111348EINECS 240-457-5FEMA No. 3236Pyran, 2-(2-methyl-1-propenyl)-4-methyltetrahydro-2H-Pyran, tetrahydro-4-methyl-2-(2-methylpropenyl)-Pyran, tetrahydro-4-methyl-2-(2-methylpropenyl)-RosenoxideRosoxideTetrahydro-4-methyl-2-(2-methylpropen-1-yl)pyranTetrahydro-4-methyl-2-(2-methylpropenyl)-2H-pyranUNII-4O51437J50

Functional Uses

Industrial and product-use categories associated with this substance.

SOURCE EPA CPDat 56 records

FragranceDeodorizerFlavouring and nutrient

Regulatory Lists

Inventory, screening, and regulatory list matches from public chemical databases.

SOURCE EPA CPDat 7 records

List	Keyword	Source
Europe	European Commission	Fl@vis
air; Cleaning products and household care - laundry and fabric treatment; detected; emissions	Elsevier	CPCat
air; Cleaning products and household care; detected; emissions	Elsevier	CPCat
air; Cleaning products and household care - air freshener; detected; emissions	Elsevier	CPCat
IFRA Transparency	IFRA	IFRA
food_additive; Substances Added to Food (formerly EAFUS) (2/2019)	FDA	United States Food and Drug Administration (FDA)
consumer_product	P&G	Proctor & Gamble

NOAEL Studies

Toxicology endpoints rendered from public NOAEL study rows.

SOURCE NOAEL studies Showing 24 of 24 studies

Value	Unit	Endpoint	Route	Species	Source
2.55	%	Concentration, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
1	%	Concentration, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
=1.2	mg/m3	DNEL systemic	inhalation	Human	ToxValDB_GESTIS_DNEL
4O51437J50	UNII	FDA UNII substance identifier	-	-	openFDA substances
4O51437J50	UNII	FDA UNII substance identifier	-	-	openFDA substances
4O51437J50	UNII	FDA UNII substance identifier	-	-	openFDA substances
4O51437J50	UNII	FDA UNII substance identifier	-	-	openFDA substances
-	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
9.804	%	Incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
775	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
1350	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
4650	ug/cm2	Induction dose per skin area	Dermal	Human	NTP_ICE_skin_sensitization
2372	ug/cm2	Induction dose per skin area, 5% incidence of positive responses	Dermal	Human	NTP_ICE_skin_sensitization
930	ug/cm2	Induction dose per skin area, one positive response	Dermal	Human	NTP_ICE_skin_sensitization
=4300	mg/kg bw	LD50	oral	Rat	NTP_ICE_acute_oral
>2.51	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
2.805	mg/kg bw/day	NOAEL	oral	rat	COSMOS_DB
>2.81	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=50	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=100	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=300	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1000	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
=1152	mg/kg bw/day	NOAEL	oral	Rat	ToxValDB_ECHA_IUCLID
3	unitless	Relative reliability score	Dermal	Human	NTP_ICE_skin_sensitization

Showing 24 of 24 studies

REACH Registration

Registration status from the ECHA REACH registered substances database.

SOURCE ECHA (EU) 1 records

Status	Name	EC Number	Link
Registered	Tetrahydro-4-methyl-2-(2-methylprop-1-enyl)pyran	240-457-5	ECHA overview →

Australian Status (AICIS)

Australian industrial chemicals inventory status and applicable conditions.

SOURCE AICIS inventory 1 records

Inventory Status

listed

Cosmetic Safety Profile

Same-CAS cosmetic ingredient record for cross-vertical context.

SOURCE CosIng / Ingredients DB

EU Status

permitted

Max

Cannabis Data

Same-CAS cannabis compliance and lab records where available.

SOURCE Cannabis regulatory / lab data efsa substances

1 cannabis record found in efsa substances.

View full cannabis profile →

Frequently Asked Questions

What is the NOAEL for 4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran?

4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran has 24 NOAEL studies in the database. The lowest reported value is 1 % via Dermal in Human. Source: NTP_ICE_skin_sensitization.

What regulatory lists include 4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran?

4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran appears on 7 regulatory/inventory lists including Europe, air; Cleaning products and household care - laundry and fabric treatment; detected; emissions, air; Cleaning products and household care; detected; emissions, and 4 more. Source: EPA CPDat.

Is 4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran used in cosmetics?

Yes, 4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran is also indexed as a cosmetic ingredient under the name Laevo-Rose Oxide. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.

Where does the safety data for 4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran come from?

Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, ECHA REACH, CosIng / Ingredients DB, cannabis regulatory/lab databases. All data traces to primary regulatory sources and is updated from official government databases.

Does 4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran have different safety status in cosmetics vs industrial chemicals?

4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran is classified GHS CMR hazard (H315, H319, H361) in the chemicals database but is allowed in EU cosmetics.

Is 4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran used outside industrial chemicals?

4-Methyl-2-(2-methylprop-1-en-1-yl)tetrahydro-2H-pyran also appears in cosmetics, cannabis databases.