Is Kava Kava Root Extract safe in cosmetics?
Kava Kava Root Extract has a safety rating of "POOR" in our database. EU status: restricted. US status: restricted.
Poor
Cosmetic Ingredient
Kava Kava Root Extract
Also known as: Kava Kava, Piper methysticum extract, Piper methysticum root, Kava-Kava resin, Resin Kava-Kava (+2 more)
INCI: PIPER METHYSTICUM ROOT EXTRACT
Kava Kava Root Extract (CAS 9000-38-8) is a cosmetic cosmetic ingredient functioning as Skin Conditioning, Soothing. EU Regulation 1223/2009 status: restricted. Industrial safety data is also available in the chemical safety database.
View industrial chemical safety profile for CAS 9000-38-8 →
Auto-generated CPSR Part A draft with source citations
Function
Skin Conditioning, Soothing
Safety Rating
POOR
Chemistry & Identifiers
IUPAC Name
2-[(E)-2-(1,3-benzodioxol-5-yl)ethenyl]-4-methoxy-2,3-dihydropyran-6-one
InChIKey
GTEXBOVBADJOQH-DUXPYHPUSA-N
Regulatory Status
EU EU Status
restricted
US US Status
restricted
US Notes
FDA issued consumer advisory on liver toxicity risk; CIR concluded insufficient data to support safety in cosmetics; use at 0.0001–0.1% per CTFA guidance
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Kava Kava Root Extract.
Calculate MoS for your specific formulation with the MoS Calculator.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
2B
Volume
108
Evaluation Year
2013
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| CA | banned | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (2)
Carcinogen Classification
Kava extract | Group 2B: Possibly carcinogenic to humans | Volume 108: (2016) Some Drugs and Herbal Products
Source: International Agency for Research on Cancer (IARC)
Carcinogen Classification
Kava Kava Extract | TR-571: Toxicology and Carcinogenesis Studies of Kava Kava Extract (CASRN 9000-38-8) in F344/N Rats and B6C3F1 Mice (Gavage Studies) (2012 ) | 01/26/11 | Equivocal Evidence | No Evidence | Clear Evidence | Clear Evidence | Under the conditions of these 2-year gavage studies, there was equivocal evidence of carcinogenic activity of kava kava extract in male F344/N rats
Source: NTP Technical Reports
Expert Verdict
Expert safety assessment and concern-level summary for Kava Kava Root Extract.
Regulatory Flags
hepatotoxic-risk
cir-insufficient-data
eu-restricted
fda-advisory
avoid-high-concentration
Known Synonyms
Kava Kava
Piper methysticum extract
Piper methysticum root
Kava-Kava resin
Resin Kava-Kava
Kava kava resin
Kawa kawa resin
Regulatory Lists
Canada; pharmaceutical
Canada; pharmaceutical
Canada; pharmaceutical
Australian Status
AICIS status: listed
Frequently Asked Questions
Is Kava Kava Root Extract allowed in the EU?
Kava Kava Root Extract EU regulatory status: restricted. This is based on EU Regulation 1223/2009 and its amendments.
What does Kava Kava Root Extract do in cosmetics?
Kava Kava Root Extract functions as: Skin Conditioning, Soothing. It is classified as a cosmetic ingredient in our database. CAS number: 9000-38-8.
Compliance Tools
Check Kava Kava Root Extract compliance across multiple jurisdictions:
Ingredient Decoder
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82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
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MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
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