What is the NOAEL for Kava kava resin?
Kava kava resin has 6 NOAEL studies in the database. The lowest reported value is 2B IARC group. Source: IARC Monographs.
NOAEL Data
IARC Group 2B
Cosmetic Ingredient
Kava kava resin
Also known as: Kava Kava, Piper methysticum extract, Piper methysticum root, Kava-Kava resin, Resin Kava-Kava (+1 more)
CAS 9000-38-8
Kava kava resin (CAS 9000-38-8) is a chemical substance; key hazard signal: IARC Group 2B. Key regulatory status: 3 regulatory/inventory lists, cosmetic ingredient cross-reference; source data from EPA ToxValDB, EPA CPDat, AICIS, IARC.
SOURCE
noael studies public
NOAEL studies
6
SOURCE
chemical inventory jurisdictions
Regulatory lists
3
SOURCE
eu clp annex vi
GHS signal
Not classified
Chemical Identity
CAS, identifiers, formula, and alternate names for the matched substance record.
SOURCE
DSSTox identifiers
9 fields
Name
Kava kava resin
CAS Number
9000-38-8
DTXSID
DTXSID5031505
Synonyms
Kava KavaPiper methysticum extractPiper methysticum rootKava-Kava resinResin Kava-KavaKawa kawa resin
IARC Carcinogen Classification
Carcinogenic hazard classification from IARC monograph evaluations.
SOURCE
IARC Monographs on the Identification of Carcinogenic Hazards to Humans
1 records
| Group | Meaning | Evaluated | Volume |
|---|---|---|---|
| Group 2B | Possibly carcinogenic | 2013 | 108 |
Regulatory Lists
Inventory, screening, and regulatory list matches from public chemical databases.
SOURCE
EPA CPDat
3 records
| List | Keyword | Source |
|---|---|---|
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
| Canada; pharmaceutical | DrugBank | DrugBank |
NOAEL Studies
Toxicology endpoints rendered from public NOAEL study rows.
SOURCE
NOAEL studies
Showing 6 of 6 studies
| Value | Unit | Endpoint | Route | Species | Source |
|---|---|---|---|---|---|
| 2B | IARC group | IARC carcinogenicity classification | - | - | IARC Monographs |
| 2 | unitless | IARC group | - | - | NTP_ICE_cancer |
| =16000 | mg/kg bw | LD50 | oral | Rat | NTP_ICE_acute_oral |
| 250 | mg/kg bw/day | POLY-3 lowest dose | Gavage | Mouse | NTP_ICE_cancer |
| 500 | mg/kg bw/day | POLY-3 lowest dose | Gavage | Mouse | NTP_ICE_cancer |
| 1000 | mg/kg | Top dose | Gavage | Mouse | NTP_ICE_cancer |
Showing 6 of 6 studies
Australian Status (AICIS)
Australian industrial chemicals inventory status and applicable conditions.
SOURCE
AICIS inventory
1 records
Inventory Status
listed
Cosmetic Safety Profile
Same-CAS cosmetic ingredient record for cross-vertical context.
SOURCE
CosIng / Ingredients DB
EU Status
restricted
Max
-
Category
Plant Extract
Frequently Asked Questions
What regulatory lists include Kava kava resin?
Kava kava resin appears on 1 regulatory/inventory list including Canada; pharmaceutical. Source: EPA CPDat.
Is Kava kava resin a carcinogen according to IARC?
Kava kava resin is classified by IARC as Group 2B — possibly carcinogenic to humans (evaluated 2013). Source: IARC Monographs on the Identification of Carcinogenic Hazards to Humans.
Is Kava kava resin used in cosmetics?
Yes, Kava kava resin is also indexed as a cosmetic ingredient under the name Kava Kava Root Extract. View the full cosmetic safety profile on the ingredient page for detailed safety data, SCCS opinions, and regulatory status.
Where does the safety data for Kava kava resin come from?
Safety data is sourced from EPA ToxValDB, EPA CPDat, AICIS (Australian Industrial Chemicals Introduction Scheme), EPA DSSTox, IARC Monographs, CosIng / Ingredients DB. All data traces to primary regulatory sources and is updated from official government databases.
Is Kava kava resin used outside industrial chemicals?
Kava kava resin also appears in cosmetics databases.