Is Kaempferol Cosmetic safe in cosmetics?
Kaempferol Cosmetic has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Kaempferol Cosmetic
Also known as: 5-18-05-00251, BRN 0304401, EINECS 208-287-6, Kaemferol, Pelargidenolon 1497 (+9 more)
INCI: KAEMPFEROL
Kaempferol Cosmetic (CAS 520-18-3) is a cosmetic cosmetic ingredient functioning as Insufficient Data. EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 520-18-3 →
Auto-generated CPSR Part A draft with source citations
Cross-Vertical Regulatory Divergence
Kaempferol Cosmetic is classified GHS Danger (H301, H341) in the chemicals database but is allowed in EU cosmetics.
Source: Cosmetics: ingredients.eu_status; Chemicals: ghs_classifications.signal_word/hazard_statement_code
Function
Insufficient Data
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
3,5,7-trihydroxy-2-(4-hydroxyphenyl)chromen-4-one
InChIKey
IYRMWMYZSQPJKC-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
CIR Cosmetic Ingredient Review Expert Panel considers GRAS status as supporting evidence in cosmetic safety assessments, though route of exposure differences must be evaluated.
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Kaempferol Cosmetic.
Calculate MoS for your specific formulation with the MoS Calculator.
IARC Carcinogenicity
International Agency for Research on Cancer (WHO) monograph evaluation.
IARC Group
3
Volume
31, Sup 7
Evaluation Year
1987
Endocrine Disruptor Evidence (Expanded)
Cross-referenced EDC classifications, mechanism data, and dose-response evidence from EDLists, SIN List, and cosmetic-specific detail sources.
Cosmetic-Specific Mechanism
Category: other
Receptor targets: ERα, ERβ
LOEC: 100 nM
EU status: allowed
agonist (ERα, ERβ)
Additional Ingredient Properties
4 property records from structured ingredient metadata.
acne
{"cas_number": "520-18-3", "anti_acne_mechanism": "anti_inflammatory", "comedogenicity_rating_0_to_5": "0", "acne_type_efficacy": "inflammatory", "sebum_reduction_pct_clinical": "0-10", "prescription_required_usa": "No", "otc_drug_monograph_category": "No", "max_otc_concentration_pct": "No limit", "japan_quasi_drug_anti_acne": "No", "korea_functional_cosmetic_acne": "No", "eu_cosmetic_restriction_…
anti_aging
{"anti_aging_claim": "antioxidant-protection, anti-inflammatory", "mechanism_of_action": "Bioactive compound, specialized mechanism", "target_skin_layer": "epidermis, dermis", "collagen_stimulation": "Mild", "elastin_protection": "Mild", "wrinkle_reduction_pct": "8-15", "clinical_study_duration_weeks": "12", "sample_size": "35", "double_blind": "No", "placebo_controlled": "Yes", "published_journal…
anti_pollution
{"cas_number": "520-18-3", "ingredient_class": "Nrf2_activator", "primary_mechanism": "free_radical_scavenging", "pollution_types_targeted": "PM2_5", "IR_A_protection": "no", "visible_light_protection": "no", "digital_screen_protection_claim": "no", "PAH_neutralization": "no", "ozone_protection": "no", "mitochondrial_protection": "no", "Nrf2_activation": "no", "AhR_pathway_modulation": "no", "NF_k…
antioxidant
{"cas_number": "520-18-3", "antioxidant_class": "flavonoid", "chemical_subclass": "flavonol", "molecular_weight_daltons": "286.24", "orac_value_umol_te_per_g": "14200", "dpph_radical_scavenging_ic50_ug_per_ml": "11-20", "abts_trolox_equivalent": "not available", "singlet_oxygen_quenching": "not available", "superoxide_dismutase_mimetic": "not available", "hydroxyl_radical_scavenging": "not availab…
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (3)
Carcinogen Classification
3, not classifiable as to its carcinogenicity to humans. (L135)
Source: Toxin and Toxin Target Database (T3DB)
Carcinogen Classification
Kaempferol | Group 3: Not classifiable as to its carcinogenicity to humans | Volume 31: (1983) Some Food Additives, Feed Additives and Naturally Occurring Substances | Volume Sup 7: Overall Evaluations of Carcinogenicity: An Updating of IARC Monographs Volumes 1 to 42, 1987; 440 pages; ISBN 92-832-1411-0 (out of print)
Source: International Agency for Research on Cancer (IARC)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Antioxidant
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Kaempferol Cosmetic.
Known Synonyms
5-18-05-00251
BRN 0304401
EINECS 208-287-6
Kaemferol
Pelargidenolon 1497
3,5,7,4'-Tetrahydroxyflavone
UNII-731P2LE49E
3,4',5,7-Tetrahydroxy-Flavone (7CI,8CI)
3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one
4H-1-Benzopyran-4-one, 3,5,7-trihydroxy-2- (4-hydroxyphenyl)-
Kampferol
Kampherol
campherol
Chemical Function
Softener and conditioner
Antioxidant
Regulatory Lists
Canada; consumer_product; Substances in Products - Canada (4/2014)
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
KAEMPFEROL
ChEMBL ID
CHEMBL150
Max Phase
1
Frequently Asked Questions
Is Kaempferol Cosmetic allowed in the EU?
Kaempferol Cosmetic EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Kaempferol Cosmetic do in cosmetics?
Kaempferol Cosmetic functions as: Insufficient Data. It is classified as a cosmetic ingredient in our database. CAS number: 520-18-3.
Is Kaempferol Cosmetic used outside cosmetics?
Kaempferol Cosmetic also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Does Kaempferol Cosmetic have different safety status in cosmetics vs industrial chemicals?
Kaempferol Cosmetic is classified GHS Danger (H301, H341) in the chemicals database but is allowed in EU cosmetics.
Compliance Tools
Check Kaempferol Cosmetic compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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