Is Diosmetin safe in cosmetics?
Diosmetin has a safety rating of "GOOD" in our database. EU status: permitted. US status: permitted.
Good
Cosmetic Ingredient
Diosmetin
Also known as: EINECS 208-291-8, 5,7,3'-Trihydroxy-4'-methoxyflavone, UNII-TWZ37241OT, 3',5,7-trihydroxy-4'-methoxyflavone, 5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone (+2 more)
INCI: DIOSMETIN
Diosmetin (CAS 520-34-3) is a cosmetic cosmetic ingredient functioning as Skin conditioning, antioxidant (O-methylated flavone; aglycone of diosmin). EU Regulation 1223/2009 status: permitted. Industrial safety data is also available in the chemical safety database. Same-CAS public records also appear in industrial chemical safety and pharmaceutical data.
View industrial chemical safety profile for CAS 520-34-3 →
Auto-generated CPSR Part A draft with source citations
Function
Skin conditioning, antioxidant (O-methylated flavone; aglycone of diosmin)
Safety Rating
GOOD
Chemistry & Identifiers
IUPAC Name
5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-one
InChIKey
MBNGWHIJMBWFHU-UHFFFAOYSA-N
Regulatory Status
EU EU Status
permitted
US US Status
permitted
US Notes
Permitted — not on FDA prohibited/restricted list
For full compliance data across multiple jurisdictions, use the Substance Compliance tool.
Safety Data
Margin of Safety, dermal absorption, and sensitization profile summaries for Diosmetin.
Calculate MoS for your specific formulation with the MoS Calculator.
ECHA REACH Registration
European Chemicals Agency REACH dossier and Substances of Very High Concern listing.
Registration Type
Full
Tonnage Band
1 - 10 tonnes
Substance Type
SUBSTANCE
SVHC Candidate
No
Expanded Jurisdictional Detail
Additional regulatory detail beyond the 7-jurisdiction summary: Saudi SFDA, Korea MFDS, ASEAN ACD, Japan/Korea, Brazil/India, and cross-jurisdictional restriction entries.
Additional Jurisdictional Restrictions (1)
| Jurisdiction | Status | Max % | Product Type |
|---|---|---|---|
| KR | prohibited | - | - |
PubChem Annotations
Safety and regulatory annotations from PubChem (NCBI) aggregated sources.
Safety (1)
Endocrine Disruptors
Potential endocrine disrupting compound
Source: NORMAN Suspect List Exchange
Function Categories & List Membership
Cosmetic/Chemical Function Categories
Softener and conditioner
Expert Verdict
Expert safety assessment and concern-level summary for Diosmetin.
Known Synonyms
EINECS 208-291-8
5,7,3'-Trihydroxy-4'-methoxyflavone
UNII-TWZ37241OT
3',5,7-trihydroxy-4'-methoxyflavone
5,7-Dihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone
Luteolin 4'-methyl ether
Salinigricoflavonol
Chemical Function
Softener and conditioner
Regulatory Lists
Canada; pharmaceutical
Cross-Vertical Safety Context
Same-CAS public records found in pharmaceutical data.
SOURCE
ChEMBL / DrugCentral / FAERS
DB_PHARMA CAS match
Pharmaceutical Data
Same-CAS rows from the pharmaceutical spoke database.
Compound
DIOSMETIN
ChEMBL ID
CHEMBL90568
Frequently Asked Questions
Is Diosmetin allowed in the EU?
Diosmetin EU regulatory status: permitted. This is based on EU Regulation 1223/2009 and its amendments.
What does Diosmetin do in cosmetics?
Diosmetin functions as: Skin conditioning, antioxidant (O-methylated flavone; aglycone of diosmin). It is classified as a cosmetic ingredient in our database. CAS number: 520-34-3.
Is Diosmetin used outside cosmetics?
Diosmetin also appears in industrial chemical safety and pharmaceutical data. The cross-vertical cards on this page render same-CAS public rows from the matched databases.
Compliance Tools
Check Diosmetin compliance across multiple jurisdictions:
Ingredient Decoder
Paste a full ingredient list for instant analysis
82 Allergen Checker
Check for EU declarable fragrance allergens
Substance Compliance
Check compliance across multiple jurisdictions
MoS Calculator
Calculate Margin of Safety using SCCS methodology
Heavy Metal Limits
Compare limits across jurisdictions
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